Xforms Post generation customisation Generated view element <xforms:input ref="//cgMDR:change_description"> Change Description Transformation <xsl:template match= <xforms:textarea ref="//cgMDR:change_description"> Change Description Customised view element <xforms:textarea ref="//cgMDR:change_description"> Change Description the cancergrid metadata registry and toolset University of Cambridge: Irene Papatheodorou, Lorna Morris; James Brenton. University of Oxford: Charles Crichton; Andrew Tsui; Steve Harris; Jim Davies; Jeremy Gibbons. reasoning SAWSDL annotations of schemas and WSDL documents support reasoning about content SQIV/XQuery uplifts the schema data model into appropriate RDF assertions from SKOS classification schemes or OWL ontologies classify elements in the data model according to the type of data and the type of user SPARQL/DL Queries can answer simple questions reliably and scalably: does the data contain personal information? which elements contain personal data? is the data suitable for the user requesting the data? XML elements/RDF triples can be replaced/blurred according to the results of the queries transformation object class: breast tumour sample property: assessment data element concept: histological type of breast tumour CDE: histological type of breast tumour Manitoba CDE: histological type of breast tumour Vancouver CDE: histological type of breast tumour Addenbrookes CDE: histological type of breast tumour Guy’s CDE: histological type of breast tumour Nottingham Enumerated Value Domain: 1 In-situ ductal only 10 Tubular/Cribiform 11 Ductal Grade Unknown 12 Mixed… Enumerated Value Domain: A None D DCIS ID Invasive ductal ID-IL … CDE: histological type of breast tumour - METABRIC meta- analysis Enumerated Value Domain: common semantics Jena rules for transformation Enumerated Value Domain: 1 Ductal NOS 10 Ductal and Spec 11 Invasive tumour 12 DCIS… conceptual domain: breast tumour histology Enumerated Value Domain: 1 Inv. ductal/no spec type 10 Tubular 11 Mucinous 12 Invasive cribriform… Enumerated Value Domain: 1 Carcinoma, NOS 10 Tubular adenocarcinoma 11 Merkel Cell Carcinoma 12 Papillary adenocarci… with the METABRIC project pathology data collected from UK and Canada metadata defined for each data type metadata defined for the transformation target with common semantics SPARQL rules defined for the transformation combined dataset used for tissue analysis similar transformation work done in XSLT working through issues of registration of transformation functions the software workgroup-scale ISO11179 metadata registry free BSD license open standards implementation: eXist; XSLT; XQuery; SKOS; RDF; XForms; XML Schema; WSDL platform independent: five minute install transforms caDSR shopping cart content simple data element registration user classification through SKOS/Protégé metadata mining with the VA ‘mining’ metadata out of CRFs from a SharePoint CTMS. custom program annotates schema elements with form text XML Schema uplifted into MDR, creating names and identifiers metadata elements curated/rationalised ‘standard’ data elements re-create schemas with SAWSDL annotations annotated schemas create registered forms smart documents We’ve connected our metadata registry, our lexBig servers, the EVS and caDSR to a query service manager giving a uniform query interface to these knowledge resources that may be accessed from both Java and.NET. You can use this service to: compose new UML models out of CDEs and register new CDEs in Enterprise Architect without leaving the class diagram ‘type a column range’ in MS Excel according to a CDE, naming the column, controlling cell display and creating a new metadata sheet with CDE definitions persisted alongside your data use CDE and concept references to design case report forms in MS InfoPath allow the user to access terminology resources when completing InfoPath based CRFs (with the VA) cgMDRlexBIGcaDSREVS query service manager (web service)