Malcolm Battin Neonatologist ACH, Chair NE Working Group, PMMRC
“ That it will ever come into general use, notwithstanding its value, is extremely doubtful; because its beneficial application requires much time and gives a good bit of trouble both to the patient and the practitioner; because its hue and character are foreign and opposed to all our habits and associations ” London Times 1834
Reduction in death or disability in hypothermia trials at m CoolingControlP valueRelative Risk (95% CI) CoolCap59/10873/ (0.67, 1.02) TOBY74/16386/ (0.68, 1.07) NICHD45/10264/ (0.54, 0.93) Eicher14/2721/ (0.41, 0.92) China28/8835/ (0.43, 0.92) ICE55/10767/ ( ) NeoNet28/5546/ (0.49, 0.81)
P Shah. Seminars In Fetal and Neonatal Medicine 2010
Shankaran S et al. N Engl J Med 2012;366:
WeeFIM ratings were completed at 7–8 y of age on 62 (32 cooled; 30 std) of 135 surviving children with neuro- developmental assessment at 18 mo Guillet R et al. Pediatric Research 2012
Only intervention that modifies outcome Standard of care Available in all level 3 units Most effective < 6 hrs after insult
Potential issues with access: Cooling did not take place in 27/82 cases (33%). Ongoing plan to review potentially eligible cases Delay Geographical Smaller units & primary birthing centres Service provision Poor uptake by a tertiary centre Inadequate guidelines and protocols
NE Working Group Data Equity in availability but variable mode ▪ informal survey NZ 3 o centres Formal collection on timing + clinical data ANZNN Cooling is an entry criteria Delayed reporting
Complete capture Accurate information LMC input Timely Protected Web based 1 st year of data in PMMRC report 2012 NZPSU 1/12 Paediatricians PMMRC NEWG LMC Website Baby form Mother form Local data Coordinator
Potential issues with access Potential issues with transport
Passive Cooling in Transport : Risk Of Over Cooling 37 / 42 babies satisfactory WRT target range 5 excessive cooling with no monitoring Passive cooling resulted in 1.8 h earlier initiation Kendall et al. Arch. Dis. Child. Fetal Neonatal Ed. 2010
Potential issues with access Potential issues with transport Problems with temperature control in NICU
Rapid induction ~ min. Potential overshoot acceptable if < 1 °C. Maintenance phase for 72 hrs minimal fluctuations servo-controlled most stable Rewarming slow and controlled rates of 0.2–0.5 °C/hr V. minimal overshoot Ongoing temperature monitoring ensure no fever Robertson Fetal and Neonatal Medicine 2010
Infant Rectal Temp During Cooling Using SHC, WBC And WBC Servo Hoque N et al. Pediatrics 2010 ©2010 by American Academy of Pediatrics
Potential issues with access Potential issues with transport Problems with temperature control in NICU Potential cooling complications
A form of panniculitis Involves back, scalp, arms 12 / 1239 cases in TOBY register of WBC Moderate-to-severe hypercalcemia in 8 / 10 with calcium measurement Skin lesions appeared after completion of cooling run Moderate hypothermia is a risk factor for SCFN Need to be aware of SCFN Monitor blood calcium
P Shah. Seminars In Fetal and Neonatal Medicine 2010
Recommendations Guidelines for cooling should ensure timely availability and access for all Evidence gap analysis by NZ guidelines group March 2012 Local centre guidelines to inform transfer of babies The key to safe transfer is core temperature monitoring Long term follow-up data vital NE working group data collection ANZNN