Malignant Fibrous Histiocytoma of Bone Associated with Type-1 Neurofibromatosis by Panayiotis J. Papagelopoulos, Andreas F. Mavrogenis, Evanthia C. Galanis,

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Presentation transcript:

Malignant Fibrous Histiocytoma of Bone Associated with Type-1 Neurofibromatosis by Panayiotis J. Papagelopoulos, Andreas F. Mavrogenis, Evanthia C. Galanis, George D. Chloros, and Kleo Th. Papaparaskeva J Bone Joint Surg Am Volume 87(2): February 1, 2005 ©2005 by The Journal of Bone and Joint Surgery, Inc.

Anteroposterior plain radiographs made when the patient was ten years old, showing multiple fibromas in the distal part of the femur and in the tibia bilaterally. Panayiotis J. Papagelopoulos et al. J Bone Joint Surg Am 2005;87: ©2005 by The Journal of Bone and Joint Surgery, Inc.

Twenty-eight years later, anteroposterior and lateral plain radiographs of the left femur showing a large destructive lytic lesion in the distal part of the left femur with thinning and erosion of the posterior cortex. Panayiotis J. Papagelopoulos et al. J Bone Joint Surg Am 2005;87: ©2005 by The Journal of Bone and Joint Surgery, Inc.

Coronal T1-weighted magnetic resonance image (A), sagittal T2-weighted image (B), axial T1- weighted image (C), and axial T1-weighted image with fat suppression (D) showing a lesion in the distal metaphyseal-diaphyseal region of the left femur, with erosion... Panayiotis J. Papagelopoulos et al. J Bone Joint Surg Am 2005;87: ©2005 by The Journal of Bone and Joint Surgery, Inc.

Histological analysis showing pleomorphic spindle cells and large histiocyte-like cells, some of which are multinucleated. Panayiotis J. Papagelopoulos et al. J Bone Joint Surg Am 2005;87: ©2005 by The Journal of Bone and Joint Surgery, Inc.

Anteroposterior and lateral radiographs of the left thigh and knee after resection of the tumor and reconstruction with a modular distal femoral and knee hinged replacement prosthesis. Panayiotis J. Papagelopoulos et al. J Bone Joint Surg Am 2005;87: ©2005 by The Journal of Bone and Joint Surgery, Inc.