Metastasis Models Folder Title: MetModels(NoTP) Updated: March 24, 2015.

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Metastasis Models Folder Title: MetModels(NoTP)

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Metastasis Models Folder Title: MetModels(NoTP) Updated: March 24, 2015

LiverMets Fig 2-1 (a)Gastric adenocarcinoma, Metastatic to the brain (b) Colon carcinoma? Metastatic to the liver

Gastric to Brain Mets

Mammary cancer metastatic to the brain. (Figure 2.2c, Biology of Cancer, p. 27)

How do we study metastases pre-clinically? How do we determine what drives them in cell biological terms? How do we develop anti-metastatic strategies to test in the clinic?

Lung Met Treatment Model: (Metastatic rat embryo cell line) Use of protease inhibitors

Progressive Selection for Highly Metastatic Malignant Melanoma in C57Bl/6 Mice (Isaiah Fidler)

Figure 2.2a The Biology of Cancer (© Garland Science 2007) p. 27 B16 Melanoma Metastatic to Mouse Lung (Experimental Metastases by Tail-vein Injection) Metastases Blocked by Treatment Metastases Unblocked TreatedPlacebo Treated

B16 F10 Model Monoclonal antibody labelling of metastatic markers Fluorescent protein labelling of metastatic cells

MetaMouse

Imaging of Metastatic Colon Carcinoma with Radioactive-Iodine-Labelled Monoclonal Ab to A33 Ag Lloyd Old, Scientific American, August, 1996, p. 138) SeeMets Arm Head Colon CA A33 Monoclonal

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Photos following show malignant melanoma in hybrid fish (Platy x Swordtail Hybrids). Fish as a metastatic cancer model Opportunity for whole body treatment

XiHi Met Model Title

Speckled Normal

Pigmented No External Tumor

External Tumor

Kidney Mets Sagittal Section

Kidney Mets Histology

XiHi Sagittal Unstained

Bio BIOLOGY OF CANCER On-Line Links to Web-sites Relating to Cancer biology and Cancer Medicine CxSciInfo.htm Caring Bridge: Stories of People and Cancer Inside Cancer: Viewing Cancer Cells from Inside (Cold Spring Harbor Laboratory). Added March 13, 2009 " Metamouse", Mouse Cancer and Other Disease Models: Anti- Cancer Incorporated." Metamouse", Mouse Cancer and Other Disease Models: Anti- Cancer Incorporated. (anticancer.com) From the course web-site under OnLine Scientific Materials: We will play now: “Inside Cancer: Viewing Cancer Cells from Inside.” Follow especially “Pathways to Cancer” with Embedded Audio Go to: