Cardiac Modeling of Steady-State Transients in the Ventricular Myocyte Raymond Tran University of Queensland July UCSD PRIME

Research Proposal To expand the Shannon et al cardiac model and its limitations by accounting for change in intracellular potassium concentration. Nimrod is a modeling system that conducts parametric sweep across multiple computing resources. Specifically, Nimrod will be integrated with the model to look for steady-state values of AP, [Ca] i, [Na] i, [K] i. Nimrod

Methods 1. Will first search for the steady-state transients by testing values of applied current and its duration in the cell. 2. Will also examine the parameters of the Na-K pump and its effect on AP and the change of intracellular Ca, Na, and K over time.

Progress of Experiment In the process of running first test experiment on Nimrod/G. Will conduct parametric sweep of the applied current in the model. Current objective is to run multiple experiments with different parameters to find steady-state transients.

Brisbane, Queensland Left: The Brisbane Wheel, located in central Brisbane. Top right: Bridge at Indooroopilly, a small town approximately 6 kilometers from the university. Bottom Right: The Brisbane River.

Acknowledgements University of California, San Diego Dr. Anushka Michailova, Department of Bioengineering. UCSD PRIME – Dr. Peter Arzberger, Dr. Gabriele Wienhausen, Ms. Teri Simas. University of Queensland Dr. David Abramson, Centre for Research Computing Hoang Nguyen, Ph.D. student at University of Queensland