NCBC EAB, January 2010 NA-MIC Highlights: A Core 1 Perspective Ross Whitaker University of Utah National Alliance for Biomedical Image Computing

NCBC EAB, January 2010 Algorithms Productivity Publications Clinical/ Biomedical Science Applied Methodology Validation/Evaluation New methods ICCV, PAMI MICCAI, MedIA, TMI NeuroImageAJNR Things we have not yet published Things we have hardly thought about

NCBC EAB, January 2010 Algorithms Productivity Software and tools Adopted by unaffiliated groups Proof of concept Reusable (by friends) One-off prototypes

NCBC EAB, January 2010 Algorithms Productivity The real goal Clinical Practice

NCBC EAB, January 2010 Diffusion MRI in Schizophrenia Lee et al, “ Increased diffusivity in superior temporal gyrus in patients with schizophrenia: a Diffusion Tensor Imaging study”, Schiz. Res Tissue classification and hand segmentation of STG Group differences and correlations with DTI measures

NCBC EAB, January 2010 DTI in Neurodevelopment Goodlett et. al, “Group analysis of DTI fi ber tract statistics with application to neurodevelopment”, Neuroimage, 2009.

NCBC EAB, January 2010 Longitudinal Studies of DTI Gouttard et. al, “Constrained Data Decomposition and Regression for Analyzing Healthy Aging from Fiber Tract Diffusion Properties”, MICCAI, Atlas based alignment and tract identification Localized statistics on longitudinal models

NCBC EAB, January 2010 Atlases and Segmentation for Scientific Studies Leemput et al., “Automated Segmentation of Hippocampal Subfields From Ultra-High Resolution In Vivo MRI”, Hippocampus, Bayesian Image analysis for parcellation of the hippocampus

NCBC EAB, January 2010 New Technologies for Atlases/Segmentation Riklin Raviv et al., “Joint Segmentation of Image Ensembles via Latent Atlases”, MICCAI 2009 Gerber et al., “On The Manifold Structure of the Space of Brain Images”, MICCAI 2009 Bootstrapping atlas with very little prior dataDiscovering/utilizing underlying parameters of large image databases

NCBC EAB, January 2010 New Technologies for Segmentation Prastawa et al., “Stastical analysis and segmentation with pathology”, 2010 Karasev et al., “Conformal Geometric Flows for Surface Segmentation”, 2010 Applications of statistical atlases with allowances for outliers Region specification by geometric flows on surfaces

NCBC EAB, January 2010 Shape Analysis in Schizophrenia Levitt et al., “Shape abnormalities of caudate nucleus in schizotypal personality disorder”, Schiz. Res., Global and local caudate shape abnormalities in male and female SPD

NCBC EAB, January 2010 Correspondence and Shape: Multimodal, Cortex Oguz et al., “Cortical correspondence with probabilistic fiberconnectivity”, IPMI, Combine shape and connectivity for group correspondence More consistent alignment of cortex relative to state of the art

NCBC EAB, January 2010 Shape and Regression/Development Datar et al., “Particle Based Shape Regression of Open Surfaces with Applications to Developmental Neuroimaging”, MICCAI, Correspondence incorporate an underlying developmental model

NCBC EAB, January 2010 Where We Are Headed Clinical Practice New Ideas Biomedical/Clinic al Science

NCBC EAB, January 2010 Stay Tuned! Investigators: –P. Golland – MIT –A. Tannenbaum – Georgia Tech –M. Stynder – UNC –G. Gerig – Utah