16 February, 2003medXchange Private & Confidential 1 Implant Register & Patient Implant Profile for: Orthopaedic, Cardiovascular, Diabetology

16 February, 2003medXchange Private & Confidential 2 Key Objectives - Quality Quality of healthcare Enable the delivery of high quality healthcare  Integration of the patient in the healthcare process  Interactive networking of healthcare professionals over open platform Provide the highest quality service  24 / 7 Availability of medical information from trustworthy sources  Healthcare consumer protection and early warning

16 February, 2003medXchange Private & Confidential 3 Implant Register & Profile: Objectives Medical incident reports & notification Consumer protection Implant & rehabilitation planning Post Manufacturing Surveillance, PMS Implant product tracing & tracking Brand protection

16 February, 2003medXchange Private & Confidential 4 Continuity of implant treatment Consulting Physician Hospital & Clinic Therapists Patient Centric Integrated Electronic Medical Record Physician Operating Physician Implant Manufacturer

16 February, 2003medXchange Private & Confidential 5 Implant Register & Profile Complete medical documentation Out of medically credible trustworthy sources Interface to medical information systems Clinics, Laboratories, Radiology, Biosensors, Dentists, etc. Patient profile & health assessment Dynamic interactive profile changes Case - disease management EBM for good medical practice - golden standards Confidential data exchange point All patient related medical and health data For authorised healthcare professionals

16 February, 2003medXchange Private & Confidential 6 Implant Register & Profile Confidential data exchange point Medical documentation Medically credible trustworthy sources Implant Product Register Data proprietary to Manufacturer Patient Implant Profile Link to Manufacturer implant data Implant & Therapy planning, Post Manufacturing Surveillance, PMS

16 February, 2003medXchange Private & Confidential 7 Manufacturer Product Register - Catalogue All information updated by Manufacturer (Data proprietary to Manufacturer) Reference and serial number Search by characteristics Descriptions, documentation Implant procedures Link to implant planning Product incident reports Product notifications

16 February, 2003medXchange Private & Confidential 8 Implant Profile Tracks and traces to physician & patient Links patient profile to Manufacturer implant data Linked to patient IEMR Implant procedure, treatment Rehabilitation treatment and care Post implant incidents and treatments Implant incident reports Post implant tracing and tracking

16 February, 2003medXchange Private & Confidential 9 Integrated Electronic Medical Record Intuitively understandable by healthcare professionals worldwide Multi Language Ergonomically structured to physicians working methods Easy to consult by patient

16 February, 2003medXchange Private & Confidential 10 Implant Report & Analysis Implant activity profile Implant medical profile Incident report analysis Post implant analysis Implant patient monitoring (Physician) Medical & regulatory authority reports

16 February, 2003medXchange Private & Confidential 11 Post Manufacturing Quality Management Implant tracing & tracking Implant planning Post implant treatment and care Medical incident reporting Implant notices and alerts Post Manufacturing Surveillance, PMS Operating & treating physician follow-up

16 February, 2003medXchange Private & Confidential 12 Manufacturer: Benefits Immediate trace of all implant products to patient Report of each implant procedure Better incident reporting Immediate notifications & alerts Decrease implant incidents Increased efficiency and success rate

16 February, 2003medXchange Private & Confidential 13 Operating & treating physician: Benefits Identification & authentication of implant products Identification of best implant practices and products Reduction of implant risks Reduction of inappropriate procedures Reduction of procedure complications Reduction of post-implant reactions Decrease implant incidents Timely identification and reaction to incidents

16 February, 2003medXchange Private & Confidential 14 Patient Benefits Security of regulated implant product and procedure Better identification and management of risks Reduction of implant risks Security of early warning system integration Reduction of subsequent medical incidents Reduction of post-implant reactions Faster recovery and restoration of body processes

16 February, 2003medXchange Private & Confidential 15 Post-implant patient care: Benefits Optimization of rehabilitation treatment and care Reduction of risks Efficient rehabilitation treatment and care Faster restoration of patient body processes

16 February, 2003medXchange Private & Confidential 16 Why the Implant Register? Integration of patient in the implant process Increase quality of post manufacturing surveillance, PMS Enhance relationship with healthcare professionals Reduce risks of implant incidents Enhance relationship and confidence of patients