Chapter 61 Experiments in the Real World

Chapter 62 Thought Question 1 Suppose you are interested in determining if drinking a glass of red wine each day helps prevent heartburn. You recruit 40 adults age 50 and older to participate in an experiment. You want half of them to drink a glass of red wine each day and the other half to not do so. You ask them which they would prefer, and 20 say they would like to drink the red wine and the other 20 say they would not. You ask each of them to record how many cases of heartburn they have in the next six months. At the end of that time period, you compare the results reported from the two groups. Give three reasons why this is not a good experiment.

Chapter 63 Experiments: Some Techniques u Double-blinding –to control experimenter/respondent bias u Pairing or blocking –to reduce a source of variability in responses –the same or similar subjects receive each treatment v different from a completely randomized design, where all subjects are allocated at random among all treatments

Chapter 64 (not) Double-Blinded: Case Study Mozart, Relaxation and Performance on Spatial Tasks (Nature, Oct. 14, 1993, p. 611) u Variables: –Explanatory: Relaxation condition assignment –Response: Stanford-Binet IQ measure u Not double-blinded –Participants know their treatment group u Single-blinded –Those measuring the IQ

Chapter 65 Double-Blinded: Case Study Quitting Smoking with Nicotine Patches (JAMA, Feb. 23, 1994, pp ) u Variables: –Explanatory: Treatment assignment –Response: Cessation of smoking (yes/no) u Double-blinded –Participants do not know which patch they received –Nor do those measuring smoking behavior

Chapter 66 Pairing or Blocking: Case Study Mozart, Relaxation and Performance on Spatial Tasks (Nature, Oct. 14, 1993, p. 611) u Variables: –Explanatory: Relaxation condition assignment –Response: Stanford-Binet IQ measure u Blocking –Participants practiced all three relaxation conditions. Each participant is a block. –IQ’s re-measured after each relaxation period

Chapter 67 Pairing or Blocking: Case Study Quitting Smoking with Nicotine Patches (JAMA, Feb. 23, 1994, pp ) u Variables: –Explanatory: Treatment assignment –Response: Cessation of smoking (yes/no) u Pairing? –Cannot block: participants can only take one treatment –Could use a matched-pairs design

Chapter 68 Experiments: Difficulties and Disasters u Extraneous variables –Confounding variables (in chapter 5) –Interacting variables u Hawthorne, placebo and experimenter effects u Refusals, nonadherers, dropouts u Extending the results (generalizing)

Chapter 69 Interacting Variables u The problem: –effect of explanatory variable on response variable may vary over levels of other variables. u The solution: –measure and study potential interacting variables. v does the relationship between explanatory and response variables change for different levels of these interacting variables? v if so, report results for different groups defined by the levels of the interacting variables.

Chapter 610 Interacting Variables: Case Study Quitting Smoking with Nicotine Patches (JAMA, Feb. 23, 1994, pp ) u Researchers considered: –smoker at home v found this to be an interacting variable: Percent quitting Nicotine Placebo Smoker at home 31% 20% No smoker at home 58% 20% – other variables: age, weight, depression v no interactions found

Chapter 611 Hawthorne, Placebo and Experimenter Effects u The problem: –people may respond differently when they know they are part of an experiment. u The solution: –use placebos, control groups, and double- blind studies when possible.

Chapter 612 Hawthorne, Placebo and Experimenter Effects : Case Study I 1920’s Experiment by Hawthorne Works of the Western Electric Company u What changes in working conditions improve productivity of workers? –More lighting? –Less lighting? –Other changes? u All changes improved productivity!

Chapter 613 Hawthorne, Placebo and Experimenter Effects : Case Study II Experimenter Effects in Behavioral Research (Rosenthal, 1976, Irvington Pub., p. 410) u Teachers given a list of student names –told these were students “who would show unusual academic development.” u IQ was measured at end of year –first graders on list: 15 points higher –second graders on list: 9.5 points higher –older: no striking difference u Great expectations = self-fulfilling prophecy –students were randomly selected (did not have high IQ)

Chapter 614 Extending the Results ( Can We Generalize? ) u The problem: –lack of generalizability due to: v unrealistic treatments v unnatural settings v sample that is not representative of population u The solution: –Researchers should use natural settings with a properly chosen sample.

Chapter 615 Extending the Results : Case Study Does Aspirin Prevent Heart Attacks? (NEJM, Jan. 28, 1988, pp ) u Participants were measured in their natural setting (at home) u Only healthy male physicians were participants –Results may not apply to: v male physical laborers v women

Chapter 616 Key Concepts u Double-Blind Experiment u Difficulties and Disasters u Experimental Designs –Completely Randomized Design –Matched Pairs Design –Block Design