10/13/20151Prof. Mazen Qato. OBJECTIVES 10/13/2015Prof. Mazen Qato2.

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Presentation transcript:

10/13/20151Prof. Mazen Qato

OBJECTIVES 10/13/2015Prof. Mazen Qato2

10/13/20153Prof. Mazen Qato

Basic PK Definitions and Principles  Volume of distribution (Vd)  Elimination constant (Ke) and half-life (t1/2)  “Steady state”  Loading dose

Volume of Distribution A proportional constant that relates the amount of drug in the body to the serum concentration If you know a drug’s Vd, you can determine how much of the drug should be given to achieve a desired plasma concentration.

10/13/20156Prof. Mazen Qato

Vd = Dose/C O Co= CONCETRATION OF DRUG AT ZERO TIME -If you know the dose and the peak plasma concentration, you can calculate the patients Vd. -If you know the Vd and have a goal plasma concentration, you can calculate the dose

FACTORS AFFECTING THE RATE OF DRUG DISTRIBUTION 1. LIPID SOLUBILITY (Kp) 2. IONISATION CONSTANT 3. MOLECULAR WEIGHT 4. BLOOD FLOW 10/13/2015Prof. Mazen Qato8

FACTORS AFFECTING THE EXTENT OF DRUG DISTRIBUTATION 10/13/2015Prof. Mazen Qato9

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THANK YOU 10/13/2015Prof. Mazen Qato18