Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14.

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Presentation transcript:

Nitric Oxide Synthase Cody A Scholtens CHE /21/14

Background L-Arginine + NADPH +H +  Citrulline +NO+ NADP + Neuronal NOS (1TLL) Endothelial NOS (2NES) Inducible NOS (1NOD)

Reaction Kinetics

Reaction Mechanism:

Crystal Structure

NOS (oxidation)

NOS (reduction)

Cofactors Flavin Dinucleotide (FAD) NADPH BH4 Tetrahydrobiopterin

Resources: 1. Switch-Found-to-Be-the-Same-for-All-Life-2.gif