Week 9 © Pearson Education Ltd 2009 This document may have been altered from the original Describe the acid and base hydrolysis of polyesters and polyamides. Outline the role of chemists in the development of degradable polymers. Explain that condensation polymers may be photodegradable and may be hydrolysed.

Week 9 © Pearson Education Ltd 2009 This document may have been altered from the original Acid and base hydrolysis of the polyester Terylene

Week 9 © Pearson Education Ltd 2009 This document may have been altered from the original Acid and base hydrolysis of the polyamide nylon-6,6

Week 9 © Pearson Education Ltd 2009 This document may have been altered from the original Identify the functional groups in an aliphatic molecule containing several functional groups. Predict properties and reactions of aliphatic molecules containing several functional groups. Devise multi-stage synthetic routes for preparing aliphatic organic compounds.

Week 9 © Pearson Education Ltd 2009 This document may have been altered from the original Summary of the reactions of aliphatic functional groups

Week 9 © Pearson Education Ltd 2009 This document may have been altered from the original Synthesis of 3-aminopropan-1-ol from 3 chloropropanal

Week 9 © Pearson Education Ltd 2009 This document may have been altered from the original Converting the aldehyde group to an alcohol functional group

Week 9 © Pearson Education Ltd 2009 This document may have been altered from the original Conversion of the halogenoalkane to the amine

Week 9 © Pearson Education Ltd 2009 This document may have been altered from the original Some important aromatic reactions

Week 9 © Pearson Education Ltd 2009 This document may have been altered from the original Structures of benzene and 3-chloronitrobenzene

Week 9 © Pearson Education Ltd 2009 This document may have been altered from the original Converting benzene into nitrobenzene

Week 9 © Pearson Education Ltd 2009 This document may have been altered from the original Chlorination of an aromatic ring

Explain that the synthesis of pharmaceuticals often requires the production of a single optical isomer. Explain that synthetic molecules often contain a mixture of optical isomers, whereas natural molecules often have only one optical isomer. Explain that the synthesis of a pharmaceutical that is a single optical isomer increases costs, reduces side effects and improves pharmacological activity. Describe strategies for the synthesis of a pharmaceutical with a single optical isomer. Chirality in Pharmaceutical Synthesis

Stereoisomers of thalidomide

Pharmacological activity depends on whether or not a drug can interact with a receptor site in a biological system.

Structure of ibuprofen, used in many medicines to relieve pain