It’s all about ATP

How do you get it?

PMF

ATP synthesis using the PMF is ancient

Cytosolic enzymes convert glucose to pyruvate The ante is 2 ATP but you get 4 if you win Plus reducing power (that’s where it’s at) (and we’re not even in the mitochondrion yet)

In the cytosol

Still in the cytosol

OK, back to the mitochondrion

porin Cardiolipin, 76% protein

The BIG picture

Coupled to e- transport 2C +4C 6C Reducing power with carbon loss Free lunch 5C 4C Kreb Tricarboxylic Citric acid Cycle

Harnessing the reducing power Converting the redox potential into the PMF

2 will get you 4: the Q cycle

Coupled to e- transport 5C 4C Remember this step?

matrix

Down to water

Now, drive ATP with the PMF