Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

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Presentation transcript:

Gaucher Disease: Bone Imaging

DXA (Dual-Energy X-ray Absorptiometry)

DXA Spine Image and Test Results

DXA Hip Image and Test Results

Absorptiometry

BMD ↓ DXA: Trabecular Bone Change

BMD ↓ DXA: Cortical Bone Change

Computed Tomography

Whole-body CT Scan With Vertebra

Close-up of Vertebra

Forearm CT Scan

Image of Radius and Ulna

TBD ↓ TBD ↔ Quantitative Computed Tomography (QCT): Trabecular Bone Change

CBD ↓ CBD ↔ QCT: Cortical Bone Change

Possible Conditions for Bone Loss Resorption ↑ Formation ↔ Resorption ↔ Formation ↓ Resorption ↑ Formation ↓ Negative Balance

Follow-up Measurements 123 Measurement BMD [g/cm 2 ]

Significant Differences 12 Measurement Point BMD [g/cm 2 ]  2.8 sd (p>95%) sd 

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