Ongoing Competitive Clinical Trials Information… Mining for Gold Zorba B. Lieberman June 6, 2005

What is TrialTrove? Global coverage of ongoing trials Customized Web-enabled database shared across the enterprise Continuously up to date Mechanism to include internal intelligence Built-in alerting system Unlimited research support Competitive Clinical Trials Surveillance Service

Themes for Today Getting the information Where ongoing trials information can be found and how much is out there Using the information Understand where your competitor is with executing on their strategy Making adjustments to your own drug development and commercialization strategy

Web sources including: Government (clinicaltrials.gov, cancer.gov) Other trials listings sources (controlled trials UK, Centerwatch) Research centers & community hospitals Company Web sites News feeds SEC filings and analyst conference calls Medical meetings Trials Information Sources

Example: Breast Cancer Trials clinicaltrials.govTrialTroveDiff. Actively Recruiting 181*3371.9x Total Trials 473*1,0922.3x * diagnostic, genetic marker, non-Rx treatment trials excluded. Source: Citeline, clinicaltrials.gov

Example: Breast Cancer Trials US Ex-US 431 (5.1x) 661 (1.7x) 473 Trials Source: Citeline, clinicaltrials.gov clinicaltrials.gov 1,092 Trials (2.3x) Ex-US TrialTrove

How Clients Use Trials Information… …to understand their competitive environment

Targeted Indications: Bay Targeted Cancer Type Number of Trials

Bay trials in 23 countries

Bay Clinical Development Program

The Value of Trials Information for CI Discovery I didnt know that [Company X] had initiated a Phase II trial in Glioblastoma..! Get depth of detail Details of trial design offer leading edge insights into competitor plans Identify patterns Asses a competitors commercialization strategy

How Clients Use Trials Information… …to adjust their own development programs as the competitive environment changes

Phase II and III Anti-VEGF Trials Targeted Cancer Type Number of Trials

Historical Enrollment Rates # Patients# Sites Enrollment Period (mos.) Enrollment Rate (pts./site/mo.) Trial # Trial # Trial # Trial # Weighted Average: 1.4 Source: Citeline (sample of Alzheimers trials data)

Using Trials Information to Make Internal Business Decisions Decide which indications to target Predict trial duration Assess protocol design Optimize geography to find patients Identify investigators/KOLs

Summary There is a lot of ongoing trials information out there, but it is very fragmented and diffuse Effectively assimilating the fragments can offer a tremendous competitive advantage Besides understanding competitors actions and intent, companies can use this information to optimize their own drug development