Infections of the Central Nervous System Zheng dongming.

Slides:

Advertisements

Similar presentations

E NCEPHALITIS Learning Objectives Overview Pathogenesis Cases of unknown aetiologyCases of unknown aetiology Causes Suspicious clinical featuresSuspicious.

Advertisements

herpes simplex virus encephalitis

Acute Intracranial Problems Megan McClintock, MS, RN Megan McClintock, MS, RN11/4/11.

Viral Myocarditis.

HSV Encephalitis Jack Kuritzky, PGY-2 UNC Internal Medicine August 31, 2009.

Encephalitis Brain Abscess Reşat Özaras, MD, Prof. Infection Dept.

VIRAL ENCEPHALITIS A range of viruses can cause encephalitis but only a minority of patients have a history of recent viral infection. In Europe, the most.

ENCEPHALITIS Presented by : 51: Abdulaziz Al-Qahtani

Infections of Central Nervous System. Section one: Survey Ⅰ. concept : all kinds of pathogens of organisms intrude into cerebral parenchyma, cerebral.

HIV dementia and HIV-related brain impairment (HRBI) Jeanette Meadway FRCP Consultant Physician Mildmay Hospital UK Hackney Road, London E2 7NA.

MEASLES RUBEOLA OR MORBILLI Department of infectious disease WANG JINGYAN.

“I Think My 17 Month Old Baby’s Drunk” Daniel P. Davis, MD UCSD Emergency Medicine.

Herpes Dr. Meg-angela Christi Amores. Herpes Simplex Etiologic agent: – Herpes Simplex Virus (HSV) DNA virus HSV 1 and HSV 2.

CNS Infection 2nd Lecture

Headache Dr. Mansour Al Moallem.

Aseptic meningitis  definition: When the CSF culture was negative.  CSF: pressure mmh2o: normal or slightly elevated. leukocytes : PMN early mononuclear.

Genital Herpes.

DNA VIRUSES DNA Enveloped Viruses I. Objectives In this lecture you will learn about properties, pathogenesis, clinical picture and diagnosis of: Herpesviruses.

ENCEPHALITIS. Selected Viral causes of acute encephalitis/myelitis Herpesvirus: Herpes simplex virus, Varicella–zoster virus, Herpes B virus, Epstein–Barr.

IN THE NAME OF ALLAH THE MOST MERCIFUL, THE MOST KIND “Blessed is He in Whose hand is the Sovereignty, and He is Able to do all things Who hath created.

Salient Features: SUBJECTIVE

Viral Encephalitis.

MENINGITIS Prof Mohammad Abduljabbar Prof Mohammad Abduljabbar.

Meningitis Pathology.

TUBERCULOUS MENINGITIS Dr Shreedhar Paudel April, 2009.

Myopathy, Neuropathy, CNS Infections Rachel Garvin, MD Assistant Professor, Neurocritical Care Department of Neurosurgery.

Toll-Like Receptors in CNS Viral Infections Unclear role of TLRs in natural infections TLR3, -7, -8, -9 recognize viral nucleic acids. Localized intracellularly.

Bacterial Meningitis - A Medical Emergency Swartz MN N Engl J Med 2004;351:

HERPES SIMPLEX ENCEPHALITIS ENCEPHALITIS M.RASOOLINEJAD, MD DEPARTMENT OF INFECTIOUS DISEASE TEHRAN UNIVERCITY OF MEDICAL SCIENCE.

Acute bacterial meningitis in infants and children

Infection of the nervous system. The clinical features of nervous system infection depend on the location of the infection [the meanings or the parenchyma.

Viral Meningitis Myra Lalas Pitt. Definition  Meningeal inflammation with negative cultures for routine bacterial pathogens in a patient who did not.

Morning Report August 9, 2010.

CNS infection Dr. V.P.C.Rajakaruna MBBS(COLOMBO).

Imaging Spectrum of Herpes Encephalitis In Paediatric Brain Abstract IDNo: 90.

Department of Neurology, The 2nd affiliated hospital, kunming Medical College Yinfengqiong.

MUMPS XIE QIFENG Dept. of Infectious Disease. Introduction Mumps is an acute respiratory tract infectious disease caused by mumps virus, it occurs primarily.

Quize of the week Hajer AlZuhair Medical resident.

MUMPS VIRUS Genus Rubulavirus. PARAMYXOVIRIDAE Paramyxovirinae Genus respirovirus: Genus Rubulavirus Genus morbillivirus Pneumovirinae Genus Pneumovirus.

MEASLES (RUBEOLA) VIRUS Genus Morbillivirus. PARAMYXOVIRIDAE Paramyxovirinae Genus respirovirus: Genus Rubulavirus Genus morbillivirus Pneumovirinae Genus.

Mike Parenteau. Etiology / Pathophysiology Encephalitis is an acute inflammation of the brain, commonly caused by a viral infection. Sometimes, encephalitis.

VIRAL ENCEPHALITIS A range of viruses can cause encephalitis but only a minority of patients with viral encephalitis have a history of recent viral.

Intracerebral Hemorrhage

ASNR 2015 Isolated Cerebellar Leptomeningeal Involvement

2011 Diagnostic Slide Session Case 7 Aditya Raghunathan Suzanne Z. Powell.

CNS INFECTION. Definitions:Definitions: Meningitis : infection predominantly involved subarachniod space.Meningitis : infection predominantly involved.

MEASLES RUBEOLA OR MORBILLI Department of infectious disease.

Encephalopathy. Encephalitis an inflammation of the brain parenchyma and presents as an alteration in consciousness, fever, headache, seizures, and/or.

What is the difference between HSV-1 and HSV-2? Both types infect the body’s mucosal surfaces, usually mouth or genitals, and then establish latency.

CNS INFECTION Dr. Basu MD. CNS INFECTION Meningeal Infection: meningitis Brain parenchymal infection { encephalitis}

A 12 years old boy with behavioral disorders F.Ahmadabadi Child neurologist.

CNS Infections J. Ned Pruitt II Associate Professor of Neurology Medical College of Georgia.

DR.S. MANSORI INFECTIOUS DISEASE SPECIALIST QAZVIN UNIVERCITY OF MEDICAL SCIENCE.

Fahareen-Binta-Mosharraf MNS. Disease-causing viruses often grouped by their route of transmission Enteric viruses Generally transmitted via fecal-oral.

Intracranial infection. Objectives To know about clinical presentation of meningitis and Encephalitis To know about the common infective organisms responsible.

Ramez Morkous MS4 Medical University Of the Americas April 29, 2016

Prognosis and Therapy of Viral Encephalitis in Adults

VIRAL ENCEPHALITIS A range of viruses can cause encephalitis but only a minority of patients with viral encephalitis have a history of recent viral.

Intracranial Infections in Neurosurgical Practice

Third year medical students Faculty of medicine, Mutah University

Acute Meningitis BY MBBSPPT.COM

Prof. Mohammad Abduljabbar

Volume 52, Issue 6, Pages (June 2015)

Encephalitis Atman Shah.

CLINICAL PROBLEM SOLVING

RUBEOLA OR MORBILLI Department of infectious disease WANG JINGYAN

Is an inflammation of cerebral tissue typically accompanied by meningeal inflammation, caused by an infection or other source.

Viruses and Encephalitis

Presentation transcript:

Infections of the Central Nervous System Zheng dongming

Pathogen all kinds of pathogens,such as virus,bacteria,Rickettsia,Spirochaet a,parasite,prion protein,etc.

Category Encephalitis:brain parenchyma Meningitis:meninges Meningoencephalitis Hematogenous disemination Neuronal spread of the virus Direct infection

Herpes simplex virus encephalitis HSE The most common type viral encephalitis.

Etiology and Pathogenisis HSV-I:90%(70%) trigeminal ganglia HSV (DNA) HSV-II:neunatal

Pathology An acute necrotic,asymmetric hemorrhagic process with lymphotic and plasma cell reaction. Usually involves the medial temporal and inferior frontal lobe.

Clinical manifestaion Prodromal infection:fever,headache,muscle pain,diarrhea. Acute onset.last for several days ~1 or 2 months unacceptably high mortality (20–30% with acyclovir) 1 focal or generalized seizure 2 behavioral disorders;cognitive function impaired,memory loss 3 hemiparesis,aphasia,ataxia,ophthalmoplegia, stiff neck,etc. 4disorder of consciousness.somnolent coma 5 intracranial pressure death

Laboratory findings CT,MRI: MRI:the most sensitive method of detecting early lesions focal oedema in the medial region of the temporal and orbital surface of the frontal lobes. Meningeal and gyral enhancement, CT usually shows reduced attenuation in one or both frontal or temporal lobes and sometimes small haemorrhages and with midline shift.

Laboratory findings EEG:slow-wave, from one or two temporal or frontal lobes. CSF: Biopsy Pressure:normal or increased cell:lymphocyte and monocyte increased,RBC. protein:increased mild glucose and CL - :normal pathogen:antigen,antibody,DNA.

Diagnosis The diagnosis of HSE is usually established from the combination of the clinical and investigative features. definitive diagnosis:find hsv in brain or CSF by all methods.

Differential Diagnosis Varicella-zoster encephalitis cytomegalovirus encephalitis gastrointestinal viral encephalitis ADEM

Treatment Antiviral therapy :Acyclovir 15~30mg/kg.d 14~21 days Ganciclovir immune therapy symptomatic therapy High fever seizure high intracranial pressure infections