KUIC - Copyright 2014 KU Innovation and Collaboration (KUIC) is the commercialization arm of the University of Kansas (all campuses): Intellectual property (IP) Corporate partnerships Industry Sponsored Research Agreements Not affiliated with clinical trials Entrepreneurship Contact: Aswini Betha, PhD; Licensing Associate – ; Matt Koenig, JD; Assistant Director – ; Shantanu Balkundi, PhD, Licensing Associate, ; Rajiv Kulkarni, PhD; Director – ; Julie Nagel, PhD; Interim Associate Vice Chancellor ; What is KU Innovation and Collaboration?

Intellectual Property Services KUIC - Copyright 2014 Market research to evaluate commercial potential Work with KU Business School, BTBC and others on market evaluation Work with faculty in evaluating the novelty and non-obviousness of the invention Create a strategy for patent filing and commercialization Invention Disclosure Invention Disclosed to KUIC and assigned to a Licensing Associate Director- Rajiv Kulkarni – Licensing Associates- Matt Koenig- Aswini Betha- Shantanu Balkundi License Negotiations Send draft license agreement to company Negotiate an acceptable deal Licensed Product Royalties received Revenue distributed License compliance IP Protection Develop a strategy for patent filing and commercialization of patentable inventions Images courtesy of Stuart Mills (2), Photokanock, pakorn, Cooldesign, watiporn, smarnad / freedigitalphotos.net Market & IP Evaluation

OWNERSHIP OF IP The Bayh-Dole Act of 1980 Allows universities (and other non-profit contractors) to:  Retain title to inventions produced under federal support  Patent technologies  License technologies Requires universities (and other non-profit contractors) to:  Share royalties with inventors  Use royalties for laboratory purposes Authorizes federal agencies to:  Protect government-owned intellectual property  Grant licenses for government-owned intellectual property  Set restrictions on licensing

INTELLECTUAL PROPERTY 1. Trade Secrets 2. Trademarks™ 3. Copyrights © 4. Patents

What is Patentable? Products Processes Plant varieties Designs Applications not just ideas Requirements for Patentability First to file Novelty Non-obviousness Utility Enabled Prior Art Information available to the public Any part of the world & in any form Before a given date relevant to patent claims KUIC - Copyright 2014 Patenting

Public Disclosure Publication Poster Presentation Offer for sale Sale Known or used by public Web Posting Prevent Public Disclosure Confidential Disclosure Agreement KUIC can help Contact KUIC well before KUIC - Copyright 2014 Public Disclosure: Loss of patent rights

Inventorship: Contribution to the conception of invention Contribution to at least one claim Not just reduction to practice Authorship is not inventorship Ownership: KU owns all intellectual property created by any KU employee in the performance of employee duties at KU using KU facilities, equipment, or funds. Kansas Board of Regents Policy - Lab Note Books: Complete, detailed records of first idea through commercial products Describe the invention clearly: words, photos, graphs, drawings, etc. Witness by a colleague “Read and understood by”, dates noted, & signed KUIC - Copyright 2014 Intellectual Property

Faculty’s Invention Disclosure - Patent protection KUIC needs Complete description of the invention. A draft manuscript, if available Reduction of the invention to practice (e.g. animal data, full prototype) Plans for further development of the technology Provisional Patent Application Place holder to establish the date of patent filing Never examined and never published by the US Patent Office Expires one year from the date of filing $ Non-provisional Patent Application Examined by Patent Office & sends an Office Action to the applicant Response to Office Action filed Issuance in 3-5 years from the date of filing $8,000 – 20,000 KUIC - Copyright 2014

10 University of Kansas Revenue Distribution Policy

Startup Support Market analysis Business planning support in coordination with BTBC –Investor presentation support –Financial modeling –Investor introduction KUIC - Copyright 2014

SELECTION OF KU START-UPS Crititech Particle-size reduction techniques for drugs CyDex[Ligand Pharma.] Cyclodextrins to improve drug solubility Echogen Protein tag system for targeted metal delivery Nanopharm [Hylapharm] Nanoconjugate drug delivery system Likarda Islet cell implants, high throughput screening Flint Hills Scientific Automated seizure detection and prediction IGX Bio Inc Prevention/treatment of HIV KC BioMedix [Innara Health] Neonatal medical devices NephroGenex [ipo 2014] Treatment of end stage renal disease (ESRD) ProQuest Developed prodrugs to reduce delivery barriers XenoTech Develop pre-clinical safety information 12

KU Medical Center 2002 W. 39th Ave. Kansas City KS Phone: (913) Fax: (913) Lawrence Campus 2029 Becker Drive Suite 142 Lawrence, KS Tele: (785) Fax: (785) KUIC - Copyright 2014