Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Mel Whitson Entomologist/Region Manager Florida and Caribbean A new, highly effective, reduced risk mosquito adulticide is coming.

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Introducing a New Molecule to Mosquito Control Etofenprox “ee-toe-fen-procks”

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Historic Moment for Mosquito Control First NEW Active Ingredient for Mosquito Control in Nearly 20 Years EPA Classified as – Pyrethroid-Like chemistry EPA Designated as Reduced Risk (Fast Track Registration) Unique Molecule: Non-Organophosphate, Non-Carbamate, Pyrethroid-Like Molecule Contains Only Carbon, Hydrogen, and Oxygen

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Low Environmental Impact Highest LD 50 - Least Oral Toxicity of Any Adulticide – Easing Public Concerns with Urban Ground/Aerial ULV Contains NO PBO - Eliminated Concerns about PBO Not Persistent in Soil, Water and Sediment- Rapid breakdown with a Half- life in Water 1.7 days, and Soil 4.4 days One of the Few Products approved for Control of Fleas and Mosquitoes on Cats

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. ETOFENPROX PERMETHRIN

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Etofenprox Mode of Action Similar mode of action to traditional pyrethroids Sodium channel blocker Contact or ingestion toxicant Quick knockdown

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Etofenprox Methoprene >34560 Resmethrin 4240 Sodium chloride 3000 Salicylic acid 1600 Pyrethrins 1500 Naled 435 Caffeine 335 Larger value = Least toxicity Etofenprox >42,880 Oral LD 50 (mg/kg) Rat d-phenothrin >5,000

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Zenivex ™ Formulation 1.5 lb. Etofenprox per gallon 20% Etofenprox by weight 7.4 lbs/gal bulk density Oil based formulation for ULV: use either undiluted or diluted

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Zenivex ™ Formulation No synergist, that is, no PBO, no related concerns Packaged in 2.5 gallon jugs and 30 gallon drums Drums will use a closed dispensing system and will be returnable at users option

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Zenivex ™ Label Highlights Application rates: , , pounds etofenprox per acre Aerial, vehicle mounted ground, or hand applied applications Droplet range for ground is microns Droplet range for aerial <60 microns No aquatic setbacks Signal word: Caution –Non-Restricted use

Zenivex is a trademark of Wellmark International. ©2008 Wellmark International. Always read and follow label directions. Zenivex™ Performance Species Evaluated to Date Aedes aegypti Aedes albopictus Aedes dorsalis Aedes melanimon Aedes nigromaculis Aedes vexans Anopheles quadrimaculatus Anopheles crucian Coquillettidia sp. Culex nigripalpus Culex slinarius Culex pipiens Culex tarsalis Culiseta melanura Ochlerotatus nigromaculis Ochlerotatus sollicitans Ochlerotatus taeniorhynchus

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Zenivex ™ Efficacy Trials More than 30 trials have been conducted over a range of rates 17 mosquito species have been tested so far Trials have been conducted across the US –Northeast, Northwest, Southeast, South and the West Good to Excellent results have been achieved at all label rates

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Zenivex™ Efficacy Trials

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Salt Lake Mosquito Abatement Ground ULV Etofenprox Trials August 12, 2008

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Salt Lake Mosquito Abatement Etofenprox Trials ~ August 12, 2008

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Species: Cx. tarsalis & Cx. pipiens Product Data –Application rate – lb. AI/Acre –2 parts BVA – 1 part Etofenprox –Flow rate 5.48 fl. oz./minute Vehicle Data –Phoenix Fogger VMD 1 psi –Truck speed 10 mph –Variable flow control Site Data –4” cardboard constructed cage nylon tulle screen –20-25 mosquitoes per cage –10-minute post application mosquitoes transferred to clean holding cage –Two cages per site –Spinning Impingers 1”-teflon coated slides –9-sites (3-100’ – 3-200’ – 3-300’ from ULV fogging truck) Meteorology –Spray start 9:25pm knots 68 o, 28% –Spray stop 9:26pm knots 68 o, 28% –Ten minutes post spray stop time mph 68 o, 28% Mosquitoes –Feral population – Cx. Tarsalis & Cx. pipiens

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Salt Lake City Mosquito Abatement District Pound Per Acre

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Chesapeake Mosquito Control Commission Norfolk, Virginia Ground ULV Etofenprox Trials September 18, 2008

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Chesapeake Mosquito Control Commission – Norfolk, Virginia Ground ULV Etofenprox Trials ~ September 18, 2008

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Chesapeake Mosquito Control Commission – Norfolk, Virginia Ground ULV Etofenprox Trials ~ September 18, 2008

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Species: Culex Quinquefasciatus Product Data –Application rate – lb. AI/Acre –Diluted BVA Oil 2 parts – 1 part Etofenprox –Flow rate 5.48 fl. oz./minute Vehicle Data –Truck speed 10 mph –Variable flow control Site Data –4” cardboard constructed cage with nylon tulle screen –20-25 mosquitoes per cage –10-minute post application mosquitoes transferred to clean holding cage –Three cages per site –Spinning Impingers 1”-teflon coated slides –9-sites (3-100’ – 3-200’ – 3-300’ from ULV fogging truck) Meteorology –August 26, 2008 Trial –Start 6:21pm mph 53 o, 78% Mosquitoes –Trial A: Culex quinquefasciatus –Trial B: Mixed feral species An. crucian An. quacrimaculatus Cs. melanura Cx. erraticus Cx. salinarius Cs. territans Oc. infirmatus Ps. ciliata Ps. ferox

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Chesapeake Mosquito Control Commission September 18, 2008 Culex quinquefasciatus

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Chesapeake Mosquito Control Commission September 18, 2008 Mixed species

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Manatee County Mosquito Control Palmetto, Florida Ground ULV Etofenprox Trials June 3-4, 2008

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Manatee County Mosquito Control, Palmetto, Florida Ground ULV Etofenprox Trials ~ June 3-4, 2008

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Manatee County Mosquito Control, Palmetto, Florida Ground ULV Etofenprox Trials ~ June 3-4, 2008 Wind 61.5° Temp 25°C 57% RH

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Species: Anopheles quadrimaculatus Product Data –Application rate – lb. AI/Acre –Dilutent BVA Oil –Uvitex fluorescence tracer –Flow rate 3.6 fl. oz./minute Vehicle Data –Vehicle speed 5 mph –London Fog 18-20: 15.8 MMD Site Data –WHO cages-transfer 25 mosquitoes per cage –Two WHO cages per site –Spinning Impingers 1-teflon coated slides –6-sites (3-50m – 3-100m from ULV fogging truck) –Droplet collection rods for fluorescence Meteorology –Spray start 23: mph 25 o C, 57% RH Mosquitoes –Colony reared – Anopheles quadrimaculatus

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Manatee County Mosquito Control, Palmetto, Florida Pound Per Acre

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Manatee County Mosquito Control, Palmetto, Florida Pound Per Acre

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. South Carolina June 22-24, 2005 Target application rate lb. AI/acre –( – ) Flow rate 1 oz./minute Natural population collections –85% Ochlerotatus taeniorhychus –15% Ochlerotatus sollicitans

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Mortality Summary – South Carolina 20 minute % Knockdown Pound Per Acre

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Mortality Summary – South Carolina 24 hour % Mortalities Pound Per Acre

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International. Always read and follow label directions. Mortality Summary – South Carolina % Mortalities vs. % Knockdown Pound Per Acre

Zenivex™ Conclusion Zenivex is a trademark of Wellmark International. ©2008 Wellmark International. Always read and follow label directions. Zenivex™ is a proven addition to the toolbox for control of adult mosquitoes –Excellent control across the rate range –Effective on all mosquito species tested Low toxicity profile No PBO synergist required Quick, permanent knockdown No odor No aquatic setbacks For use aerially and by ground Proven performance used undiluted or diluted

Zenivex is a trademark of Wellmark International. ©2008 Wellmark International. Always read and follow label directions. Special thanks to these and others: Pasco County Mosquito Control District, FL St. Tammany Parish Mosquito Control, LA Georgetown County Mosquito Control, SC Mosquito Research & Control Unit, Grand Cayman Manatee County Mosquito Control, FL Orange County Mosquito Control, FL Cascade County Mosquito Control, MT Salt Lake City Mosquito Abatement, UT Churchill County Mosquito Control, NV Gem County Mosquito Abatement District, ID Chesapeake Mosquito Control Commission, VA

Zenivex is a trademark of Wellmark International. ©2008 Wellmark International. Always read and follow label directions. For More Information