The Infectious Diseases Institute Kampala, Uganda InfoPoverty World Conference United Nations InfoPoverty World Conference United Nations Robert L. Mallett Senior Vice President Corporate Affairs Pfizer Inc

2 What We Do Source: PhRMA, based on data from Center for the Study of Drug Development, Tufts University, ,000–10,000 Screened 250 Enter Preclinical Testing 5 Enter Clinical Testing 1 Approved by the FDA Phase II 100–300 Patient Volunteers Used to Look for Efficacy and Side Effects Phase III 1,000–5,000 Patient Volunteers Used to Monitor Adverse Reactions to Long-term Use FDA Review Approval Additional Post-marketing Testing Phase I 20–80 Healthy Volunteers Used to Determine Safety and Dosage Preclinical Testing Laboratory and Animal Testing Discovery (2–10 Years) Compound Success Rates by Stage Years

3 Effective Social Investment We Focus on Where We Add the Greatest Value –Long-Term Commitment to Health Problems –Focus on Achievable, Measurable Health Outcomes –Leverage the Full Resources of the Company –Fostering Innovative Approaches to Public Health Challenges We Have More to Offer Than Money –Medicines, Organizational Influence, Leadership, and Our People We Cannot Do It Alone –We Work in Partnership Effective Social Investment We Focus on Where We Add the Greatest Value –Long-Term Commitment to Health Problems –Focus on Achievable, Measurable Health Outcomes –Leverage the Full Resources of the Company –Fostering Innovative Approaches to Public Health Challenges We Have More to Offer Than Money –Medicines, Organizational Influence, Leadership, and Our People We Cannot Do It Alone –We Work in Partnership What We Believe Guiding Principles

4 How We Help Access to Medicines Infrastructure Development Health Provider Training Company Expertise Patient Education Pfizer People Infrastructure Development Health Provider Training Company Expertise Patient Education Pfizer People Global Health: Systemic Improvements in Building Capacity

5 Health Care in Uganda: Challenges and Opportunities Absence of Primary Health Care Infrastructure Lack of Trained Health Care Professionals Transient, Mobile Patient Populations Lack of Equipment and Medical Facilities Vertical Programs Absence of Primary Health Care Infrastructure Lack of Trained Health Care Professionals Transient, Mobile Patient Populations Lack of Equipment and Medical Facilities Vertical Programs Responsive, Engaging Government Existing Medical School with Significant HIV/AIDS Expertise Stable Environment Resources and International Donors Opportunities Challenges

6 Infectious Diseases Institute, Kampala, Uganda Goal: To Build and Sustain Regional Clinic, Laboratory and Medical Training Center for the Diagnosis, Treatment and Prevention of HIV/AIDS

7 Model Partnership Makerere University in Kampala –One of the Leading Medical Schools on the Continent San Francisco AIDS Foundation/Pangaea –Program Administration and Project Manager for Construction Infectious Diseases Society of America (IDSA) –Developed Intensive Month-Long HIV/AIDS Training Curriculum and Provides Trainers The AIDS Support Organization (TASO) –Largest Indigenous Organization in Africa Providing Patient Counseling and Support Pfizer –Financial Support and Technical Assistance (e.g. Pfizer Engineers and IT Support; Medicines; Pfizer Global Health Fellows) Makerere University in Kampala –One of the Leading Medical Schools on the Continent San Francisco AIDS Foundation/Pangaea –Program Administration and Project Manager for Construction Infectious Diseases Society of America (IDSA) –Developed Intensive Month-Long HIV/AIDS Training Curriculum and Provides Trainers The AIDS Support Organization (TASO) –Largest Indigenous Organization in Africa Providing Patient Counseling and Support Pfizer –Financial Support and Technical Assistance (e.g. Pfizer Engineers and IT Support; Medicines; Pfizer Global Health Fellows)

8 Matching Needs to Resources IDI Technology Needs Infrastructure/Wiring Integration of Clinical Laboratory System Identification and Implementation of an Electronic Record Keeping System Installation of a Research Database to Administer Data Collection for Clinical Trials Creation of a Clinical Training Program for New Physicians IDI Technology Needs Infrastructure/Wiring Integration of Clinical Laboratory System Identification and Implementation of an Electronic Record Keeping System Installation of a Research Database to Administer Data Collection for Clinical Trials Creation of a Clinical Training Program for New Physicians Donors ($1.8M in IT support ) Pfizer Microsoft Cisco SAS Oracle Hewlett Packard Elsevier Science Skyscape PALM Inc

9 Impact of Infectious Diseases Institute Training 200 Physicians Trained Each Year Treatment 3,000+ Patients Receive Regular Care Operational Research New Studies on Adherence Prevention and Outreach Counseling for Patients AIDS Center Provides Information for Physicians Training 200 Physicians Trained Each Year Treatment 3,000+ Patients Receive Regular Care Operational Research New Studies on Adherence Prevention and Outreach Counseling for Patients AIDS Center Provides Information for Physicians

10 Critical But Unforeseen Benefits Workplace Safety Program –Transferring World Class Health & Safety Standards Makerere School of Architecture –Students Benefiting From Project Engineering and Architecture Local Procurement of Resources –Support Kampala Economy Creating Entrepreneurial Opportunities –Local Contracting Company Won Bid to Construct New British High Commission Sharing Best Practices –Pfizer Promoting Lessons Learned Workplace Safety Program –Transferring World Class Health & Safety Standards Makerere School of Architecture –Students Benefiting From Project Engineering and Architecture Local Procurement of Resources –Support Kampala Economy Creating Entrepreneurial Opportunities –Local Contracting Company Won Bid to Construct New British High Commission Sharing Best Practices –Pfizer Promoting Lessons Learned