Training in Pathology Informatics Funding Opportunities Michael J. Becich, MD PhD Course Director, APIII ( Chairman, Dept of Biomedical Informatics Professor of Biomedical Informatics, Pathology, Information Science and Telecommunications ( Center for Clinical and Translational Informatics (

Overview NCRR - CTSA Clinical Research Training Programs NLM - Biomedical Informatics Training Programs Quantitative Mentored Investigator Awards K99/R00 CAP Foundation and Industry Funding Conclusions

Clinical Community National Center for Research Resources Accelerating research from basic discovery to improved patient care Improved patient care Pre-clinical animal model resources imaging & informatics advances clinical research support research capacity & training community engagement science education

NIH Roadmap –

mouse MRI insertion tube NCRR

Building A National CTSA Consortium 38 Sites with CTSA Awards since 2006 (Goal = 60)

Funded CTSA sites First Round Duke Clinical and Translational Science Institute Duke UniversityDuke Clinical and Translational Science Institute Irving Institute for Clinical and Translational Research Columbia UniversityIrving Institute for Clinical and Translational Research Mayo Center for Translational Science Activities Mayo ClinicMayo Center for Translational Science Activities Oregon Clinical and Translational Research Institute Oregon Health and Science UniversityOregon Clinical and Translational Research Institute Rockefeller University Center for Clinical and Translational Science The Rockefeller UniversityRockefeller University Center for Clinical and Translational Science The UCSF Clinical and Translational Science Institute University of California, San FranciscoThe UCSF Clinical and Translational Science Institute UC Davis Clinical and Translational Science Center University of California, DavisUC Davis Clinical and Translational Science Center University of Pennsylvania Institute for Translational Medicine and Therapeutics University of PennsylvaniaUniversity of Pennsylvania Institute for Translational Medicine and Therapeutics University of Pittsburgh Clinical and Translational Science Institute University of PittsburghUniversity of Pittsburgh Clinical and Translational Science Institute University of Rochester Clinical and Translational Sciences Institute University of Rochester School of Medicine and DentistryUniversity of Rochester Clinical and Translational Sciences Institute University of Texas Houston Center for Clinical and Translational Sciences University of Texas Health Sciences Center at HoustonUniversity of Texas Houston Center for Clinical and Translational Sciences Yale Center for Clinical Investigation Yale UniversityYale Center for Clinical Investigation

Funded CTSA sites Second Round Atlanta Clinical and Translational Science Institute (Atlanta-CTSI) Emory University (partnering with Morehouse School of Medicine)Atlanta Clinical and Translational Science Institute (Atlanta-CTSI) CTSA at Case Western University Case Western UniversityCTSA at Case Western University CTSA at Weill Cornell Medical College Weill Cornell Medical College (partnering with Hunter College)CTSA at Weill Cornell Medical College Johns Hopkins Institute for Clinical and Translational Research Johns Hopkins UniversityJohns Hopkins Institute for Clinical and Translational Research Michigan Institute of Clinical and Health Research University Of Michigan At Ann ArborMichigan Institute of Clinical and Health Research North and Central Texas Clinical and Translational Science Initiative University of Texas Southwestern Medical Center – DallasNorth and Central Texas Clinical and Translational Science Initiative University Of Wisconsin Madison Institute for Clinical and Translational Research University Of Wisconsin MadisonUniversity Of Wisconsin Madison Institute for Clinical and Translational Research University of Chicago CTSA University Of ChicagoUniversity of Chicago CTSA University of Iowa's Institute for Clinical and Translational Science University Of IowaUniversity of Iowa's Institute for Clinical and Translational Science University of Washington Institute of Translational Health Sciences University Of WashingtonUniversity of Washington Institute of Translational Health Sciences Vanderbilt Institute for Clinical and Translational Research Vanderbilt University (partnering with Meharry Medical College)Vanderbilt Institute for Clinical and Translational Research Washington University Institute of Clinical and Translational Sciences Washington UniversityWashington University Institute of Clinical and Translational Sciences

Funded CTSA sites Third Round Albert Einstein-Montefiore Institute for Clinical and Translational Research Albert Einstein College of Medicine (partnering with Montefiore Medical Center)Albert Einstein-Montefiore Institute for Clinical and Translational Research Clinical and Translational Science (BU-BRIDGE) Institute Boston UniversityClinical and Translational Science (BU-BRIDGE) Institute Colorado Clinical and Translational Sciences Institute University of Colorado DenverColorado Clinical and Translational Sciences Institute Harvard Catalyst: The Harvard Clinical and Translational Science Center Harvard UniversityHarvard Catalyst: The Harvard Clinical and Translational Science Center Indiana Clinical and Translational Science Institute Indiana University School of MedicineIndiana Clinical and Translational Science Institute Institute for Integration of Medicine and Science (IIMS) The University of Texas Health Science Center at San AntonioInstitute for Integration of Medicine and Science (IIMS) Northwestern University Clinical and Translational Sciences Institute Northwestern UniversityNorthwestern University Clinical and Translational Sciences Institute The Ohio State University Center for Clinical and Translational Science The Ohio State UniversityThe Ohio State University Center for Clinical and Translational Science The Scripps Translational Science Institute The Scripps Research InstituteThe Scripps Translational Science Institute The Stanford Center for Clinical and Translational Education and Research Stanford UniversityThe Stanford Center for Clinical and Translational Education and Research Translational and Clinical Science (TraCS) Institute The University of North Carolina at Chapel HillTranslational and Clinical Science (TraCS) Institute Tufts Clinical and Translational Science Institute Tufts UniversityTufts Clinical and Translational Science Institute UAB Center for Clinical and Translational Science The University of Alabama at BirminghamUAB Center for Clinical and Translational Science University of Utah Center for Clinical and Translational Science The University of UtahUniversity of Utah Center for Clinical and Translational Science

52 Sites with CTSA Planning Grants Brown University Children's Research Institute Dartmouth College Emory University Georgetown University Harvard University Medical School Howard University Pennington Biomedical Research Center Medical College of Georgia Medical College of Wisconsin Medical University of South Carolina Meharry Medical College Methodist Hospital Research Institute Michigan State University Mount Sinai School of Medicine New York University School of Medicine Stanford University State University New York Temple University Texas A&M University Health Science Center Translational Genomics Research Institute University of Massachusetts Medical School University of Medicine Dentistry of New Jersey University of Alabama University of Arkansas for Medical Sciences University of Cincinnati University of Colorado Denver Health Sciences University of Connecticut School of Medicine University of Florida University of Hawaii University of Illinois University of Kansas Medical Center University of Kentucky University of Louisville University of Maryland School of Medicine University of Missouri University of New Mexico University of North Carolina University of North Dakota University of Oklahoma Health Sciences Center University of South Carolina University of South Florida University of Southern California University of Tennessee Health Science Center University of Texas Health Science Center University of Virginia University of Washington University of Wisconsin Virginia Commonwealth University Wake Forest University Health Sciences Wayne State University Weill Medical College Cornell University

Informatics at first 12 CTSA sites MJB’s Impression (disclaimer!!!) All Twelve CTSA sites have a component of Research IT support –Includes implementation, enhancement, support of existing systems Pathology Informatics is grossly under-represented (except maybe in Tissue Banking Informatics) Punch line – every program in CTSA (as a requirement for funding) has to have a training program in clinical research and have a biomedical informatics core!!!

CTSA Training Programs CTSA has (by requirement) training programs (K and T programs of NIH) and clinical and translational research centers (CTRCs, formerly GCRCs) K Programs (for junior faculty) – Career Development and Mentorship Programs Clinical Research Scholars Program Focus is to take MDs and train them in clinical research Pathology is not taking advantage of this major opportunity T Programs (for residents and fellows) Clinical Research Training Program –Certificate program (1 yr) available at most institutions Designed for trainees – clinical & translational research fellowship Pathology is not taking advantage of this major opportunity

Total number of active trainees

NLM Biomedical Informatics Training Programs = 20

NLM Biomedical Informatics Training Programs = University of California Irvine Irvine, CA, Program contact: Pierre BaldiUniversity of California IrvinePierre Baldi 2. University of California Los Angeles Los Angeles, CA, Program contact: Alex BuiUniversity of California Los AngelesAlex Bui 3. Stanford University Stanford, CA, Program contact: Russ AltmanStanford UniversityRuss Altman 4. University of Colorado Denver/ Aurora, CO, Program contact: Larry Hunter University of Colorado Denver/Larry Hunter 5. Yale University New Haven, CT, Program contact: Sandra FrawleyYale UniversitySandra Frawley 6. Regenstrief/Indiana University Indianapolis, IN, Program contact: Steve DownsRegenstrief/Indiana UniversitySteve Downs 7. Harvard University Boston, MA, Program contact: Lucila Ohno-MachadoHarvard UniversityLucila Ohno-Machado 8. Johns Hopkins University Baltimore, MD, Program contact: Kersti Winny Johns Hopkins University Kersti Winny 9. University of Missouri-Columbia Columbia, MO, Program contact: Bill CaldwellUniversity of Missouri-ColumbiaBill Caldwell 10. Columbia University Health Sciences NY, NY Program contact: Marina HonablueColumbia University Health SciencesMarina Honablue 11. Oregon Health & Science University Portland, OR; Program contact: Bill HershOregon Health & Science UniversityBill Hersh 12. University of Pittsburgh Pittsburgh, PA; Program contact: Toni PorterfieldUniversity of PittsburghToni Porterfield 13. Vanderbilt University Nashville, TN; Program contact: Cindy GaddVanderbilt UniversityCindy Gadd 14. Rice University Houston, TX; Program contact: Tony GorryRice UniversityTony Gorry 15. University of Utah Salt Lake City, UT; Program contact: Scott NarusUniversity of UtahScott Narus 16. University of Virginia Charlottesville, VA; Program contact: Stephanie GuerlainUniversity of VirginiaStephanie Guerlain 17. University of Washington Seattle, WA; Program contact: Brian BrownUniversity of WashingtonBrian Brown 18. University of Wisconsin Madison Madison, WI; Program contact: Louise PapeUniversity of Wisconsin MadisonLouise Pape NOTE: Red #s are sites that do not yet have a CTSA Funded Training Program

NLM Training Programs Focused on 3 types of training: –PhD – major focus –MS – major focus –Certificates (one year generally) – excellent for Pathology Informatics trainees Great for informatics networking even if your program is “stand alone” Short term training opportunities also available – summer, 3 month rotation Major demand see 10x10 program –

Quantitative Mentored Investigator Award (K25) NIH Pathway to Independence (PI) Award (K99/R00) The K25 award will provide support and “protected time” for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research. Requires mentor Requires training plan Requires research plan

K99/R00 (so called “kangaroo”) Pathway to Independence Awards Purpose The NIH Pathway to Independence Award will provide up to five years of support consisting of two phases. The initial phase will provide 1-2 years of mentored support for highly promising, postdoctoral research scientists. This phase will be followed by up to 3 years of independent support contingent on securing an independent research position. The PI Award is limited to postdoctoral trainees. This program expires January 3, 2010 unless reissued. NLM supports research career development in biomedical informatics and bioinformatics. We define informatics as the intersection of computer, information and behavioral sciences with one or more application domains. Application domains of interest include health care delivery, basic biomedical research, clinical and translational research, public health and others. Whatever the application domain, the research career focus must be informatics. Preference will be given to applicants who received their informatics training at one of NLM's university-based training programs in Biomedical Informatics. NLM Contact Clinical and Public Health Informatics: Dr. Hua-Chuan Sim, Bioinformatics and Computational Biology: Dr. Jane Ye, Deadlines for New Applications: February 12, June 12, and October 12 each year Deadlines for Revised Applications: March 12, July 12, and November 12 each year Full listing of deadlines for competing applications: NIH Pathway to Independence (PI) Award (K99/R00)

CAP Foundation Scholars Research Program – sponsored by CAP and Seracon Award Amount: Up to $12,500 for six months Up to $25,000 for one year Intended for salary support. Recipient’s institution is expected to contribute benefits and overhead costs and may provide a support supplement. Assurance must be given that facilities and direct support sufficient for the work proposed by the applicant will be provided throughout the term of the grant. This award is made to the scholar, not the institution. It may, with cause, be terminated at any time. Recipients who choose not to accept the award may list the recognition on their curriculum vitae. Purpose: The purpose of the award is to help facilitate the transition from residency to an independent investigator. Therefore, persons who have already been awarded major research support for the previous academic year will not be eligible. Time Commitment: Projects must be completed within one (1) year. For those who are in a second year fellowship, the project must be completed within three (3) years after completing residency. Applicants must plan to spend their fellowship year in basic or applied research, and are expected to work full-time as defined in their project plan. Eligibility: Residents at the PGY 2 level, and up to those doing a second year fellowship. Residents who are more than three years post-residency training are not eligible. Applicants must be a CAP Member or have an application pending.

CAP Foundation Advanced Training in Pathology Informatics - Sponsored by McKesson Award Amount: Allowance provided for travel and living expenses. It is expected that the recipient’s own institution will continue to provide for salary and benefits during the award period. Purpose: To offer background and experience to pathology residents to introduce and implement advanced informatics technology in the clinical laboratory. After the rotation, the resident will be able to: Identify the following factors important in introducing and utilizing new information technology in the clinical laboratory: –Medical decision support systems and artificial intelligence –Electronic medical record –Digital multimedia and imaging applications –Telepathology and telemedicine –Outcomes research and data mining –Process control, quality control, and quality assurance Demonstrate ability to recognize and utilize information concerning new trends and technology in pathology. Commitment: Four (4) weeks, must be completed between 5/1/09 – 8/31/09. Eligibility: Pathology residents or those in fellowships. It is a requirement that candidates have adequate training and experience in informatics. Applicants must be a CAP Junior Member.

CAP Foundation Research in Telepathology - Sponsored by Nikon Award Amount: $5,000 to cover expenses incurred during the grant period, and for travel to attend a national meeting to present an abstract/paper summarizing study results. Purpose: To further developments in and use of information technology for the practice of pathology. Time Commitment: This grant is intended to facilitate a six- month study. Eligibility: Pathology residents and those in fellowships who are still in training. Applicants must be a CAP Junior Member or have an application pending.

CAP Foundation Research in Telepathology - Sponsored by Olympus Award Amount: $5,000 to cover expenses incurred during the grant period, and for travel to attend a national meeting to present an abstract/paper summarizing study results. Purpose: To further developments in and use of information technology for the practice of pathology. Time Commitment: This grant is intended to facilitate a six- month study. Eligibility: Pathology residents and those in fellowships who are still in training. Applicants must be a CAP Junior Member or have an application pending.

Conclusions Pathology Informatics trainees should consider clinical research training programs in CTSA sites – 38 Pathology Informatics trainees should consider biomedical informatics training programs – 18 Other funding opportunities exist in your institution, foundations and from industry –Communicate with CAP Foundation Make it happen, there are options!!!

End of Talk – me at if you have questions or need clarifications about the discussion. End of Talk – me at if you have questions or need clarifications about the discussion. NOTE: Please me if you want a copy of this presentation or contact me for additional help in training resources nationally –