Anticoagulant, Antiplatelet, and Thrombolytic Drugs

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Anticoagulant, Antiplatelet, and Thrombolytic Drugs Chapter 50 Anticoagulant, Antiplatelet, and Thrombolytic Drugs Copyright (c) 2004 Elsevier Inc. All rights reserved.

Anticoagulant, Antiplatelet, and Thrombolytics Drugs Hemostasis Stage 1—formation of platelet plug Platelet aggregation Stage 2—coagulation Intrinsic system Extrinsic system

Heparin Rapid-acting anticoagulant Uses Pulmonary embolism Stroke evolving Vein thrombosis Adverse effects – Hemorrhage – Heparin-induced thrombocytopenia – Hypersensitivity reactions Protamine APTT

Warfarin (Coumadin) Oral anticoagulant Antagonist vitamin K Affects synthesis—factors VII, IX, X, and prothrombin Uses Long-term prophylaxis of thrombosis Adverse effects – Hemorrhage PT link

Antiplatelet Drugs Aspirin (ASA) Inhibition of cyclooxygenase Ticlopidine (Ticlid) ADP receptor antagonists Clopidogrel (Plavix) ADP receptor antagonist

Thrombolytic Drugs Streptokinase Binds plasminogen Uses Myocardial infarction Deep vein thrombosis Massive pulmonary emboli Adverse effects Bleeding – Antibody production Hypotension Fever