Does knowing personal genomic information change behavior? Nate Cira Gene 210 6/5/2012

Importance Are there benefits to testing? Are there risks from testing? Should people be tested? Should tests be regulated? Relation to other medical risk factors?

Class Related Anecdotes Robin Starr – Breast cancer Rosalind Chuang – Denial and Insistence Steve Quake – Statins

Single Alleles 35 article review Including colorectal cancer, Alzheimer’s, breast and ovarian cancer Short term distress and anxiety Slightly increased screening Perceived risk increases then returns to noncarrier by a year Heska et al. Genetics in Medicine. 2008

Scripps Study Navigenics test 6 month follow-up ~2000 surveyed Large dropout Bloss et al. NEJM 2011

Keyan’s survey Initial 210 class Found better learning in those genotyped Submitted for publication

This year’s survey: Population Population 19 responses 16 were genotyped/3 were not 9 female/10 male

Behavior: Exercise

Behavior: Diet

Behavior

Outlook: Non-health

Outlook: Health

Outlook: Anxiety

Sharing

Anticipation

Engagement

Pressure

Genotyping

Conclusions Sample size Self-reporting Short term Links between gender and anxiety Representative? Other medical risk factors?

Questions ?

Thoughts Bias against improved health and exercise Might in future insist on extra testing Small sample size Self reporting All people changing anxiety were female

'Does knowing personal genomic information change behavior?' - Why is this question important - Studies on single alleles (BRCA, ect.) - Scripps study and associated literature - Keyan's survey - Anecdotes from Robin, and Steve Quake - Results from my survey - Summary and concluding remarks