Dubravka Šipuš, 2nd year 2013/2014 Mentor: A. Žmegač Horvat.

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Presentation transcript:

Dubravka Šipuš, 2nd year 2013/2014 Mentor: A. Žmegač Horvat

 Hemostasis – prevention of blood loss  Mechanisms: 1) Vascular constriction 2) Formation of a platelet plug 3) Formation of a blood clot 4) Growth of fibrous tissue

 Fast process  Procoagulants and anticoagulants  Complex cascade of chemical reactions  Blood coagulation factors

 Formation of prothrombin activator  Extrinsic pathway  Intrinsic pathway

 Endothelial surface factors (smoothness, glycocalyx, thrombomodulin)  Antithrombin III - heparin cofactor  Coumarin (warfarin)  Citrate ion, oxalate

 Vitamin K deficiency  Diseases of the liver  Hemophilia  Thrombocytopenia

 Hemophilia A - abnormality or deficiency of Factor VIII  Recessive sex-linked, X chromosome disorder

 Guyton, Hall: Textbook of Medical Physiology