Serotonin Syndrome: The ten minute version Russell Berger, MD.

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Serotonin Syndrome: The ten minute version Russell Berger, MD

Clinical Triad Altered mental status Dysautonomia Hyperreflexia (lower extremity>upper extremity)

Relevant History New serotonergic agent(usually in addition to one old agent) Rapid onset of symptoms

What are some of the more common serotonergic agents Tramadol Demerol TCA’s SSRI’s Lithium MAOi’s Linezolid(yes, the abx) Trazodone Valproic acid Tryptophan St John’s Wort Ginseng

Complications of Serotonin Syndrome Seizures Rhadbomyolysis Hyperthermia Metabolic Acidosis Renal Injury Death

Treatment Options Benzodiazepines – No risk Cyproheptadine(5HT-2A antagonist) – Anticholinergic

The diagnostic dilemma

Questions