B-Cell Epitopes Chapter 10

Antibodies

Antibody - Antigen interaction Paratope Fab Epitope Antibody

Antibody Effect Virus or Toxin Neutralizing Antibodies

B-Cells Stem Cell Precurser B-lymphocytes Gene rearrangements B-lymphocytes each displaying a unique B-cell receptor

Gene Shuffling José Saldanha © 2000. Birkbeck College, London WC1E 7HX.

B-Cell Activation No Affinity No Affinity Low Affinity Somatic Hypermutations High Affinity Plasma cells Memory B-cells

B-Cell Activation T Helper Cell TCR B Cell Class II MHC Bound Peptide

Cartoon by Eric Reits

Structural Epitopes

Discontinuous Epitopes

CDR Regions CDR = complementarity determining region Variable regions Alpha-carbon trace of the structure of the heavy chain and light chain variable regions of a typical antibody. The framework regions of both chains are shown in grey whilst the complementarity determining regions (CDRs) are coloured individually, i.e. Heavy chain CDR 1 = Light blue CDR 2 = Cerise CDR 3 = Yellow Light Chain CDR 1 = Red CDR 2 = Green CDR 3 = Blue CDR = complementarity determining region http://212.219.234.139/html/anti_alpha.html