DNA: Not Merely the Secret of Life Bio-Inspired Bottom-Up Nanoscale Control of the Structure of Matter Nadrian C. Seeman Department of Chemistry New.

Slides:

Advertisements

Similar presentations

NSF-ITR: EIA : Structural DNA Nanotechnology

Advertisements

James Chappell & Cheuk Ka Tong

Assembly of DNA Graphs whose Edges are Helix Axes Phiset Sa-Ardyen*, Natasa Jonoska** and Nadrian C. Seeman* *New York University, New York, NY **University.

Ashish Gupta Ashish Gupta Unremarkable Problem, Remarkable Technique Operations in a DNA Computer DNA : A Unique Data Structure ! Pros.

Two States of the Array B. Ding & N.C. Seeman, Science 314, (2006).

Recombinant DNA technology

Mansi Mavani Graduate Student Department of Physics, OSU Stillwater

13-2 Manipulating DNA.

Abstract: Self-assembly is beginning to be seen as a practical vehicle for computation. The assembly of DNA-based tiles into 2D periodic arrays had been.

Topics in Biological Physics Design and self-assembly of two-dimensional DNA crystals Benny Gil 16/12/08 Fig3.a.

What makes DNA Computing possible? Great advances in molecular biology –PCR (Polymerase Chain Reaction) –DNA Selection by affinity –DNA Filtering –DNA.

What Is the Intellectual Goal of Structural DNA Nanotechnology? Controlling the Structure of Matter in 3D to the Highest Extent (Resolution) Possible,

Mao, C., LaBean, T.H., Reif, J.H. & Seeman, N.C. (2000), Nature 407, A Cumulative XOR Calculation: Assembly.

Presented By:- Anil Kumar MNW-882-2K11

 Restriction Enzymes are part of the essential tools of genetic engineering. They have the ability to cut DNA molecules at very precise sequences of.

Genetic Engineering and The Human Genome

Chapter 20~DNA Technology & Genomics. Who am I? Recombinant DNA n Def: DNA in which genes from 2 different sources are linked n Genetic engineering:

The Design of Autonomous DNA Nanomechanical Devices: Walking and Rolling John H. Reif Duke University.

III Manipulating DNA. The Tools of Molecular Biology How do scientists make changes to DNA? The Tools of Molecular Biology.

Lesson Overview Lesson Overview Studying the Human Genome Lesson Overview 14.3 Studying the Human Genome.

DNA-Scaffolded Self-Assembling Nano-Circuitry An Ongoing Research Project with Dr. Soha Hassoun Presentation by Brandon Lucia and Laura Smith.

Technological Solutions. In 1977 Sanger et al. were able to work out the complete nucleotide sequence in a virus – (Phage 0X174) This breakthrough allowed.

Manipulating DNA.

Section 2 Genetics and Biotechnology DNA Technology

LECTURE PRESENTATIONS For CAMPBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert.

KEY CONCEPT Biotechnology relies on cutting DNA at specific places.

Chapter 6 Molecular Biology of DNA Replication and Recombination Jones and Bartlett Publishers © 2005.

TOPICS IN (NANO) BIOTECHNOLOGY Self-assembly 10th June 2003.

AP Biology DNA Study Guide. Chapter 16 Molecular Basis of Heredity The structure of DNA The major steps to replication The difference between replication,

BIOTECHNOLOGY. What is biotechnology? Aspect of technology that uses: - biological data - molecules - organisms for alternative practices.

PHARMACOBIOTECHNOLOGY.  Recombinant DNA (rDNA) is constructed outside the living cell using enzymes called “restriction enzymes” to cut DNA at specific.

Chapter 20 DNA Technology & Genomics. Genetic engineering Manipulation of genetic material for practical purposes has begun industrial revolution in biotechnology.

Researchers use genetic engineering to manipulate DNA. Section 2: DNA Technology K What I Know W What I Want to Find Out L What I Learned.

KEY CONCEPT Biotechnology relies on cutting DNA at specific places.

Introduction to Biotechnology Chapter 13. What is biotechnology? “ Any technique that uses living organisms or their products to make or modify a product,

Chapter 10: Genetic Engineering- A Revolution in Molecular Biology.

Genetic Engineering Genetic engineering is also referred to as recombinant DNA technology – new combinations of genetic material are produced by artificially.

Manipulating DNA. Scientists use their knowledge of the structure of DNA and its chemical properties to study and change DNA molecules Different techniques.

Presented by Pardeep Dhillon and Ehsan Fadaei

Biology Chapter 9 & Honors Biology Chapter 13 Frontiers Of Biotechnology.

Genetic Engineering How do scientists make changes to DNA?

Recombinant DNA Technology. DNA replication refers to the scientific process in which a specific sequence of DNA is replicated in vitro, to produce multiple.

TileSoft: Sequence Optimization Software for Designing DNA Secondary Structures P. Yin*, B. Guo*, C. Belmore*, W. Palmeri*, E. Winfree †, T. H. LaBean*

Section 14-3: Studying the Human Genome. Manipulating DNA The SMALLEST human chromosome contains 50 million bases DNA is a HUGE molecule that is difficult.

Chapter 20 DNA Technology and Genomics. Biotechnology is the manipulation of organisms or their components to make useful products. Recombinant DNA is.

CH. 20 WARM-UP Share 3 things you are grateful for. Use your textbook (Ch. 20) to answer the following review questions. 1. What is recombinant DNA? 2.

FOOTHILL HIGH SCHOOL SCIENCE DEPARTMENT Chapter 13 Genetic Engineering Section 13-2 Manipulating DNA.

Vocab review Unit 8 - biotechnology. 1. Organism that has acquired genetic material by artificial means.

Automated DNA Sequencing AP Biology Fall Automated DNA Sequencing  Currently, laboratories use automated DNA sequencing to determine the unknown.

DIGESTION OF DNA WITH RESTRICTION ENZYMES

Recombinant DNA Technology

Section 2 Genetics and Biotechnology DNA Technology

DNA Technology Now it gets real…..

Programmable DNA Lattices: Design Synthesis & Applications

Chapter 14 Bioinformatics—the study of a genome

KEY CONCEPT Biotechnology relies on cutting DNA at specific places.

KEY CONCEPT Biotechnology relies on cutting DNA at specific places.

The student is expected to: (6H) describe how techniques such as DNA fingerprinting, genetic modifications, and chromosomal analysis are used to study.

Recombinant DNA Technology

KEY CONCEPT Biotechnology relies on cutting DNA at specific places.

Genetics and Biotechnology

Crystal Structure of a Continuous Three-Dimensional DNA Lattice

Unit 1.2 Review.

KEY CONCEPT Biotechnology relies on cutting DNA at specific places.

KEY CONCEPT Biotechnology relies on cutting DNA at specific places.

KEY CONCEPT Biotechnology relies on cutting DNA at specific places.

KEY CONCEPT Biotechnology relies on cutting DNA at specific places.

At the Crossroads of Chemistry, Biology, and Materials

Using the DNA Sequence Knowing the sequence of an organism’s DNA allows researchers to study specific genes, to compare them with the genes of other organisms,

Presentation transcript:

DNA: Not Merely the Secret of Life Bio-Inspired Bottom-Up Nanoscale Control of the Structure of Matter Nadrian C. Seeman Department of Chemistry New York University New York, NY 10003, USA ned.seeman@nyu.edu Workshop on the Computational World View and the Sciences Princeton University December 11, 2006

B-DNA

A Theoretical Tool To Generate Reciprocal Exchange: A Theoretical Tool To Generate New DNA Motifs Seeman, N.C. (2001), NanoLett. 1, 22-26.

Reciprocal Exchange in a Double Helical Context Seeman, N.C. (2001), NanoLett. 1, 22-26.

Design of Immobile Branched Junctions: Minimize Sequence Symmetry Seeman, N.C. (1982), J. Theor.Biol. 99, 237-247.

Sticky-Ended Cohesion: Smart Affinity

Sticky-Ended Cohesion: Structure Qiu, H., Dewan, J.C. & Seeman, N.C. (1997) J. Mol. Biol. 267, 881-898.

The Central Concept of Structural DNA Nanotechnology: Combine Branched DNA with Sticky Ends to Make Objects, Lattices and Devices Seeman, N.C. (1982), J. Theor.Biol. 99, 237-247.

OBJECTIVES AND APPLICATIONS FOR OUR LABORATORY ARCHITECTURAL CONTROL AND SCAFFOLDING [1] MACROMOLECULAR CRYSTALLIZATION (PERIODIC IN 2D AND 3D). [2] NANOELECTRONICS ORGANIZATION (PERIODIC IN 2D AND 3D). [3] DNA-BASED COMPUTATION (APERIODIC IN 2D OR 3D). [4] CONTROL OF POLYMER AND MATERIALS COMPOSITION & TOPOLOGY. NANOMECHANICAL DEVICES [1] NANOROBOTICS. [2] NANOFABRICATION.

Seeman, N.C. (1982), J. Theor.Biol. 99, 237-247. A New Suggestion for Producing Macromolecular Crystals Seeman, N.C. (1982), J. Theor.Biol. 99, 237-247.

Robinson, B.H. & Seeman, N.C. (1987), Protein Eng. 1, 295-300.. A Method for Organizing Nano-Electronic Components Robinson, B.H. & Seeman, N.C. (1987), Protein Eng. 1, 295-300..

Why DNA? Predictable Intermolecular Interactions: Both Affinity and Structure. Can Design Shape by Selecting Sequence: Robust Branched Motifs Programmable by Sequence. Convenient Automated Chemistry: Both Vanilla DNA and Useful Derivatives. Convenient Modifying Enzymes: Ligases, Exonucleases, Restriction Enzymes, Topoisomerases. Persistence Length ~500 Å; Stiff Branched Motifs Have Been Developed. Locally A Stiff Polymer: Robust Molecule: Can Heat Individual Strands without Doing Damage. Amenable to Molecular Biology and Biotechnology Techniques: Gels, Autoradiography, PCR. Externally Readable Code when Paired: Different Points in a Lattice Can be Addressed. High Functional Group Density: Every 3.4 Å Nucleotide Separation. Prototype for Many Derivatives: The Gene Therapy Enterprise Has Generated Hundreds of Analogs Potentially Self-Replicable and Selectable: May be Able to Make and Improve Constructs Inexpensively.