Signal Transduction Pathways

Slides:



Advertisements
Similar presentations
G Linked Receptors (Continued…….). Serine/Threonine Protein Phosphatases Rapidly Reverse the Effects of A-Kinase.
Advertisements

Chapter 11: Cell Communication
Cell Communication Chapter 11 Local regulators – in the vicinity a.Paracrine signaling – nearby Cells are acted on by signaling Cell (ie. Growth factor)
UW-M Cell Biology (Bio Sci 315) Cell Signaling & Signal Transduction Steroid hormones (also thyroid hormone) enter cells to regulate gene expression. Signal.
Cell Communication.
Signal Transduction Pathways
Lecture 2, Oct 11 Important points from 10/7:
Medical Biochemistry Membranes: Membrane receptors; G-proteins Lecture 73 Membranes: Membrane receptors; G-proteins Lecture 73.
Mechanisms of Cell Communication
Chapter 11 Cell Communication. Cell Signaling Evolved early in the History of Life.
Cell Communication Chapter 11:. Why do cells communicate? Regulation - cells need to control cellular processes. Environmental Stimuli - cells need to.
Chapter 7 Cell Communication. Question? u How do cells communicate? u By “cellular” phones. u But seriously, cells do need to communicate for many reasons.
11.2 Reception: A signaling molecule binds to a receptor protein, causing it to change shape A receptor protein on or in the target cell allows the cell.
Cell Communication (Signaling) Part 2
Biological Hierarchy:
Lecture 22 Signal Transduction 1. Important Concepts in Signal Transduction Primary messengers Membrane receptors Second messengers Amplification Signal.
Channel-linked Receptors aka: ligand-gated channels a receptor type seen in synaptic transmission rapid response (ms) limited response –depolarization.
Second Messengers and Signal Transduction
Basic Concepts of Metabolism
The 3 Steps.  Intracellular Receptors ◦ Proteins in the cytoplasm or in the nucleus ◦ Example: transcription factors  Receptors in the Plasma Membrane.
Signal Transduction Biochemistry – February 23, 2005 Chapter 12 – parts 12.3, 12.4.
Cell Communication AP Biology.
B. Signal Transduction Pathway (cell signaling)
Cell Signaling & Communication. Cellular Signaling cells respond to various types of signals signals provide information about a cell’s environment.
Chap. 15 Problem 2 Signaling systems are classified based on the distance over which they act. Endocrine signaling acts over long distances within the.
Please turn in your completed case study (all parts!)
Chapter 11: Cell Communication
Warm-Up  Why do you communicate?  How do you communicate?  How do you think cells communicate?  Do you think bacteria can communicate? Explain.
Part V Second Messengers. The first messengers being the extracellular signal molecules and the third messengers being the large protein kinases and phosphatases.
Cell Communication Chapter 11 p Evolution of Cell Signaling There is great similarity in cell-signaling mechanisms of yeasts & mammals ▫Suggests.
Cytokines, Growth Factors and Hormones SIGMA-ALDRICH.
University of Jordan1 Receptors Functions and Signal Transduction- L3 Faisal I. Mohammed, MD, PhD.
Chapter 15- Cell Communication Part I- General signaling strategies Part II- G protein signaling Part III- Enzyme-linked cell surface receptors Part IV-
Communication- signal pathways Distinguish among types of cell-to-cell communication List the four classes of membrane receptors. Explain how receptors.
Cell to Cell Communication
CHAPTER 11 CELL COMMUNICATION. Local ‘talk’: Paracrine Signaling (local secretions from neighboring cells), direct cell to cell ‘talk’/via diffusible.
Cell Communication Chapter 11.
Signal Transduction Pathways
Caffeine Signaling via Ligand-Receptor Binding Agonist - ligand binding to a receptor and eliciting a response Antagonist - ligand binding to a receptor.
Chapter 11 Cell Communication. LE 11-2 Exchange of mating factors Mating Receptor a   factor a  a factor Yeast cell, mating type a Yeast cell, mating.
Cell Communication Chapter 9.
Chapter 14. Signal Transduction Signal transduction is the process by which an extracellular signal alters intracellular events. 1. First and second messengers.
Lecture #5 Membrane Transport & Cell Communication.
Cell Communication.
11.3 Transduction: Cascades of molecular interactions relay signals from receptors to target molecules in the cell  Signal transduction usually involves.
Lecture: Cell Signaling
Chapter 15 Cellular Signal Transduction The biochemistry and molecular biology department of CMU.
CHAPTER 11 CELL COMMUNICATION Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings Section C: Signal-Transduction Pathways 1.Pathways.
Cell Communication Chapter 11 p
B Chapter 11~ Cell Communication. Signal-transduction pathway I b Def: Process by which a signal on a cell’s surface is converted into a specific cellular.
Chapter 11 RQ 1. What is a type of “local signaling” for cells? 2. What is communicated through “long distance” signaling? 3. What is the first stage.
Signal transduction The process of converting extracellular signals into cellular responses. extracellular signaling molecules (ligands) synthesized and.
Revised curriculum (1) December 16 (Tuesday) Second messengers
Chapter 14: Signal Transduction
Signal transduction. General scheme There are two general types of receptors: cell-surface and intracellular receptors.
An Introduction to Medicinal Chemistry 3/e PROTEINS AS DRUG TARGETS:
Pharmacodynamics III Receptor Families
3.D.3 Signal Transduction Signal transduction pathways link signal reception with cellular response.
Cell Communication Chapter 11.
OVERVIEW: Signals for cell surface receptors (hydrophilic):
Cellular Signaling Ch. 11.
Chapter 11 Cell Communication.
Cell Communication (Signaling) Part 2
Signal trasduction via cAMP
Cell Communication (Signaling) Part 2
Cell Communication AP Biology.
Cell Communication.
Cell Communication (Signaling) Part 2
Cell Communication (Signaling) Part 2
Review Quiz Please open this review in a slide show mode. Answer a question first, then go to the next slide for the correct answer.
Presentation transcript:

Signal Transduction Pathways An introduction to Information metabolism Chapter 15 Stryer Biochemistry

Signal Transduction 1) Membrane receptors transfer information 2) Second messengers relay information from the receptor ligand complex. 3) Protein phosphorylation is a common means of information transfer

Second messengers

Second messengers

Second messengers

Second messengers

Protein Phosphorylation

7TM helix receptors The 7TM helix receptors change conformation upon binding of ligand and activate a G-Protein Rhodopsin Β-adrenergenic receptor

Activated G-Protein transmits signal by binding to other proteins G-Protein binding to adenylate cyclase increases the catalytic efficiency of the adenylate cyclase and increases the synthesis of cAMP inside the cell

G-Proteins spontaneously reset themselves Resetting the G-Protein

Receptor resetting

cAMP stimulates the phosphorylation of many target proteins by activating PKA 1) Glycogen metabolism 2) Expression of specific genes (CREB) 3) Synaptic transmission Serotonin binds to a 7TM helix receptor cAMP activates PKA PKA facilitates the closing of K channels by phosphorylation

Hydrolysis of Phosphatidyl inositol Bisphosphate

What are the biocehmical effects of IP3? IP3 causes the rapid release of Ca from intracellular stores (ER, SR) Causes smooth muscle contration Glycogen breakdown Vesicle release

Diacylglycerol activates PKC

Ca Ion is a ubiquitous cytosolic messenger

Ca activates the regulatory protein Calmodulin

Regulation of Calmodulin of Calmodulin kinase

Receptor dimerisation

JAK phosphorylates STAT5

Some receptors contain a tyrosine kinase domain within their covalent structures

Defects in signaling pathways can lead to cancer and other diseases

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2024 SlidePlayer.com Inc. All rights reserved.