22 September, 2006 Chapter 9 Mutation and Repair.

Slides:



Advertisements
Similar presentations
Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal.
Advertisements

DNA repair and mutagenesis BIOL122a Prof. Sue Lovett.
Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals.
DNA Replication, Repair, & Recombination Chapter 12 By: Alison Avery.
Isolation of Mutants; Selections, Screens and Enrichments
DNA damage & repair.
DNA damage and repair Types of damage Direct reversal of damage Excision repair in prokaryotes and eukaryotes base excision nucleotide excision Nonhomologous.
Repair mechanisms 1. Reversal of damage 2. Excision repair 3. Mismatch repair 4. Recombination repair 5. Error-prone repair 6. Restriction-modification.
DNA damage, repair and recombination
Lecture 15: DNA Organization, Replication and Repair Reading Assignment: Chapter 38, pgs ; Harper’s Biochemistry (25 th edition). Objective: To.
Gene Mutation *Mutation Chromosome mutations/aberrations Classification of Mutations 1. Spontaneous vs. Induced Spontaneous mutation Induced mutation 2.
DNA Synthesis •Eukaryotes
DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.
The Damage and Repair of DNA The molecular basis of point mutations 1. Base substitution (mismatches) transition transversion Two main types of DNA damage:
The Mutability and Repair of DNA
Chapter 20 DNA Replication and Repair. Replication is bidirectional.
BME 130 – Genomes Lecture 23 Genome evolution I: Mutations, repair, and recombination.
Microbial Genetics (Micr340) Lecture 14 DNA Repair and Mutagenesis.
 MUTAGENESIS  DNA DAMAGE  DNA REPAIR  RECOMBINATION.
The Mutability and Repair of DNA
Definitions: ★ replication errors ★ spontaneous DNA damage
Dr Mohammad S Alanazi, MSc, PhD Molecular Biology KSU DNA repair: mechanisms, methods to study DNA repair, syndromes.
Mutations, Mutagenesis, and Repair Chapter 10. The Problem DNA extremely long, fragile DNA extremely long, fragile Subject to both physical and chemical.
DNA Replication, Repair, and Recombination BIO 224 Intro to Molecular and Cell Biology.
Mutations and mutagens
Chapter 9 The Mutability and Repair of DNA
William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 15 Gene Mutation, DNA Repair, and Transposition Copyright.
Welcome Each of You to My Molecular Biology Class.
Maintenance of genomes Correcting replication errors Repairing DNA damage.
Copyright © 2009 Pearson Education, Inc. Chapter 15 Lecture Concepts of Genetics Tenth Edition Gene Mutation, DNA Repair, and Transposition.
Chapter 18 – Gene Mutations and DNA Repair
Chapter 14 Molecular Mechanisms of Mutation and DNA Repair Jones and Bartlett Publishers © 2005.
Gihan E-H Gawish, MSc, PhD Ass. Professor Molecular Genetics and Clinical Biochemistry KSU 10 TH WEEK DNA damage, repair & Mutagenesis.
Copyright © 2009 Pearson Education, Inc. Art and Photos in PowerPoint ® Concepts of Genetics Ninth Edition Klug, Cummings, Spencer, Palladino Chapter 16.
DNA Repair Supplement Read and digest please. Things that Damage DNA 1. Radiation - Cosmic 2. Chemicals - in the environment 3. DNA Replication Accidents.
Lecture 7 DNA repair Chapter 10 Problems 2, 4, 6, 8, 10, 12, and 14
Chapter 9 The Mutability and Repair of DNA
The Mutability and Repair of DNA
Gene Mutation, DNA Repair, and Transposition
MUTAGENS AND MUTAGENESIS. Mutagens  Naturally occurring mutations are referred as spontaneous mutations and are thought to arise through chance errors.
Chapter 8: Bacterial Genetics. Genetic changes in bacteria occur via: -mutations -gene transfer.
Gihan E-H Gawish, MSc, PhD Ass. Professor Molecular Genetics and Clinical Biochemistry KSU 10 TH WEEK DNA damage, repair & Mutagenesis.
1.Structures and Functions of Nucleic Acids 2.Organization and Content of Genomes 3.DNA Replication 4.The Mutability and Repair of DNA 5.DNA Recombination.
Today’s Agenda: 1. A Microarray Primer 2. Guest Speaker: Dr. Michael Schlador 3. Follow-up: the Use of Microarray Analysis in Chemotherapeutics 4. Preview.
MUTATIONS & HUMAN GENETICS Chapter 11.3, Chapter 12.
DNA Replication and Repair Chapter 13.3 AP Biology Fall 2010.
11.1DNA Is Reproduced by Semiconservative Replication.
Genetics NewsGenetics News. Mutation - Overview Mechanism of mutation Spontaneous Induced Duplication/Insertions Mechanism (example: lacI) Fragile X syndrome.
Aim :How are the mistakes that occur during DNA replication repaired?
ReactionBasePairingMutationMispairing DeaminationCGUA ATHypoxanthineC DeaminationGCXanthineC AkylationCG5’-methyl C Gene scilencing or A AkylationGCO6-methyl.
Variation Mutations DNA repair
DNA Repair.
DNA damage, repair & Mutagenesis
DNA Mutation.
Transcription Course: Molecules to Cells Lecturer: David Mu DNA Repair.
DNA Mutations and Repair
Mutations + Recombination = Genetic Variation!!
DNA Mutation.
Mutation Point Mutations Spontaneous Induced Depurination Deamination
DNA Mutations and Repair
Chapter 5.2 McGraw-Hill Ryerson Biology 12 (2011)
 MISMATCH REPAIR: corrects mistakes when DNA is copied
The Mechanism of DNA Replication
DNA Repair.
Satish Pradhan Dnyanasadhana College, Thane(w)
Mutations + Recombination = Genetic Variation!!
Figure 4.1 Semiconservative DNA synthesis.
Chapter 9 Mutation and Repair 24 September, 2004.
原核生物DNA的修复机制 潘明 柯永培 罗霞.
Investigation 1 Claims:
Presentation transcript:

22 September, 2006 Chapter 9 Mutation and Repair

Overview DNA is replicated with high fidelity, but errors do occur. Errors during replication may be misincorporation or slippage. Errors that are not repaired by proofreading may be repaired my the mismatch repair systems. Mismatch repair systems rely on methylation to determine which base is correct. In addition to replication errors, DNA can be damaged by radiation, chemicals, or spontaneous reactions. DNA repair systems are specialized according to the type of damage they address.

Transitions and Transversions

Ratification of unrepaired errors

Mismatch Repair

Dam Methylation in E. coli

Exonuclease activity exposes lesion

DNA Damage

Base Analogs and Intercalators

Photoreactivation

O6-Me-G repair

Base excision repair

Fail-safe systems

Excision Repair

Excision repair may be coupled to transcription.

Translesion Synthesis

Ames Test

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2024 SlidePlayer.com Inc. All rights reserved.