Pharmacology – Pot-pourri Peggy Andrews, Instructor Chemeketa CC
Analgesics
Opiates & Opiate Blockers
We’ll talk about Buprenex Stadol Vicodin Demerol Morphine sulfate Fentanyl Nubain Trexan Narcan
Buprenex (Buprenorphine) Class –Opioid analgesic (agonist – antagonist) –Schedule V Indications –Management of moderate to severe pain
Action –Binds to opiate receptors in CNS (30x morphine and 3x narcan) –Alters perception of and response to pain –Produces generalized CNS depression
Contraindications –Hypersensitivity Precautions –Increased ICP Adverse reactions, SE –Confusion –Dysphoria –Hallucinations –Sedation –sweating
Route & dosage –IV, 0.3 mg q 4-6 h prn How supplied –0.3 mg/ml in 1 ml preload
butorphanol tartrate (Stadol) Class –Opioid analgesic (agonist/antagonist) Indications –Management of moderate to severe pain –Analgesic during labor
Action –Binds to opiate receptors in CNS –Alters perception of response to painful stimuli Contraindications –Hypersensitivity –Opioid dependency
Precautions –Head trauma –Increased ICP Adverse reactions, SE –Confusion –Dysphoria –Hallucinations –Sedation –Sweating –Use with extreme precautions in patient on MAO Inhibitors
Route & dosage –1 mg q 3-4 h prn How supplied –1 mg/ml or 2 mg/ml in 1 ml preloads
Vicodin (Anexia, Hydrocodone bitartrate w/ acetaminophen) Class –Analgesic –Contains 5 mg narcotic, 500 mg acetaminophen –Schedule III Indications –Analgesic for moderate to severe pain
Action –Binds to opiate receptors –Acetaminophen produces peripheral and central mechanisms
Contraindications –Hypersensitivity Precautions –Head injuries Adverse reactions, SE –Respiratory depression –Sedation –Dizziness –Mental clouding –Acetaminophen overdose may result in potentially fatal hepatic necrosis
Route & dosage –1 – 2 tablets q 4-6 h prn PO –Total 24-hour dose should not exceed 8 tablets
Meperidine HCl (Demerol) Class –Opioid analgesic –Schedule II Indications –Moderate or severe pain Action –Binds to opiate receptors in CNS
Contraindications –Hypersensitivity Precautions –Head injury –Increased ICP Adverse reactions, SE –Seizures –Confusion, sedation –Hypotension –Constipation –N/V
Route & dose –50 – 100 mg slow IV, SQ, IM How supplied –10 mg/ml in 5 ml preload, –20 mg/ml, or 50 mg/ml in 5 ml preload
Morphine Sulfate (MS contin) Class: Opioid analgesic Indications –Pulmonary edema –Pain –MI Action –Acts on opiate receptors to block sensation of pain. Also causes peripheral vasodilation
Contraindications –Head injury –Depressed respiratory drive –Hypotension Precautions: have intubation equipment and naloxone ready
Adverse reactions, SE –Respiratory depression –hypotension –Confusion –Sedation –constipation
Dosage & Route –2-10 mg slow IVP q min. in 2 mg increments, titrated to relief How supplied –10 mg/ml in 1 ml tubex
Fentanyl Class –Opioid analgesic –Schedule II Indications –Analgesia Action –Binds to opiate receptors in CNS, altering response to and perception of pain
Contraindications –Hypersensitivity Precautions –Geriatrics –Diabetes –CNS tumors –alcoholism
Adverse reactions, SE –Apnea –Laryngospasm Route & dosage – mcg (0.05 – 1.0 mg) How supplied –0.05 mg/ml in one ml preload or tubex
Nubain (nalbuphine) Class –Opioid analgesic (Agonist/antagonist) Indication –Moderate to severe pain Action –Binds to opiate receptors –Alters perception of and response to pain
Contraindications –Hypersensitivity –Opioid dependency Precautions –Head trauma –Increased ICP
Adverse reactions, SE –Dizziness –Headache –Sedation –Dry mouth –N/V –Clammy feeling, sweating
Route & dosage –10 mg g 3-6 h (not to exceed 20 mg) IV How supplied –10 mg/ml in 1 and 10 ml vials or –20 mg/ml in 1 and 10 ml vials –1 ml preloads
Trexan Class –Opiate receptor agonist Indications –Alcoholics to decrease compulsive consumption –Detoxified addicts to stay opiate-free
Action –Competes for opiate receptors Contraindications –None noted Precautions –None noted Adverse reactions, SE –Abdominal cramps, –H/A –Depression –irritability
Route & dosage –25 mg tablets, PO; repeat if no withdrawal sx in one hour –Alcohol dependence; 50 mg qd PO
Narcan (naloxone) Class –Opioid antagonist Indication –Reversal of CNS depression and respiratory depression 2ndary to opiate overdose
Contraindications –Hypersensitivity Precautions –Cardiovascular disease –Pregnancy Adverse reactions, SE –None in emergent setting
Route & dosage –2 mg IV, SQ, IM, ET, SL injection –Repeat prn
nitrous oxide (Nitronox) Class –Analgesic Indications –Moderate to severe pain Action –Alters perception of pain –Decreases hypoxia
Contraindications –Do not administer for abdominal pain –Severe head injury Precautions –Must be self- administered –N/V
Route & dosage –Inhaled, blended mixture of 50% nitrous oxide and 50% oxygen –Effects dissipate within 2-5 min. after cessation of administ. –Unit consists of oxygen & nitrous oxide cylinders, fed into blender; delivered to modified demand valve
Benzodiazepines And a Benzodiazepine Antagonist
We’ll talk about Valium Versed Lorazepam & Flumazanil
diazepam (Valium) Class –Anticonvulsant –Sedative hypnotic agent –Skeletal muscle relaxant –Schedule IV Indications –seizures –Anxiety –Pre-paralytic –Pre-cardioversion –Alcohol withdrawal
Action –Depresses CNS –Produces anterograde amnesia –Has anticonvulsant properties
Contraindications –Hypersensitivity –Comatose patients –Pre-existing CNS depression Precautions –Hepatic dysfunction
Adverse reactions, SE –Dizziness –Drowsiness –Lethargy
Dosage & route Seizures –5 – 10 mg IV; may repeat q 10 – 15 min. to total dose of 30 mg Precardioversion –5 – 15 mg IV; 5 min. before Sedation –5 – 15 mg IV slowly
midazolam Versed Class –Sedative/hypnotic (benzodiazepine) –Schedule IV Indications –Used to produce sedation preoperatively –Antegrade & retrograde amnesia –Provides conscious sedation
Action –Acts at many levels of the CNS to produce generalized CNS depression; produces short- term sedation
Contraindications –Shock –Pre-existing CNS depression Precautions –Pulmonary disease –CHF –Renal impairment –Severe hepatic impairment –Geriatric or debilitated patients –children
Adverse reactions, SE –Cardiac arrest –Apnea –Laryngospasm –Bronchospasm –Respiratory depression –Phlebitis at IV site
Route & dosage –0.5 – 1 mg slow IV or IM initially –May repeat in 2-3 minutes up to max dose of 5 mg. How supplied –1 mg/ml in 2, 5, and 10 ml vials and preloaded syringes
lorazepam (Ativan) Class –Anti-anxiety, sedative hypnotic –Schedule IV Indications –Anxiety –Preoperative sedation –Seizures
Action –Depresses CNS –Decreases seizures
Contraindications –Hypersensitivity Precautions –Myasthenia gravis Adverse reactions, SE –Apnea –Cardiac arrest –Dizziness –Drowsiness –lethargy
Route & dosage –Amnesia 2-4 mg slow IV –Seizures 50 mcg IV May repeat in min. –Sedation 2-4 mg slow IV or IM –How supplied 2 mg/ml in 1 or 2 ml tubex syringe
flumazanil (Romazicon) Class –Antidote (benzodiazepine antagonist) Indications –Reverses the effect of benzodiazepines Action –Antagonizes CNS depressant effects of benzodiazepines. Has no effect on CNS depression from other causes
Contraindications –Hypersensitivity Precautions –Mixed CNS depressant overdose –History of seizures –Head injury Adverse reactions, SE –Seizures –Dizziness –N/V
Route & dosage –0.2 – 0.5 mg IV –Maximum dose 3 mg in a one hour period How supplied –0.1 mg/ml in 5- and 10- ml vials
Barbiturates
Brevital Class –Ultra-short acting barbiturate –Schedule IV Indications –Cardioversion –Induction of anesthesia Action –Affects CNS
Contraindications –None noted Precautions –Cardiac arrest Adverse reactions, SE –Hypotension –Laryngospasm –Seizures –shivering
Route & dosage –1-2 mg/kg IV How supplied –Brevital is a freeze-dried nonpyrogenic mixture of methohexital sodium with anhydrous sodium carbonate as a buffer. A white crystalline powder, freely soluble in water. –Prepare and use promptly. –Dilute with sterile water, 0.9% sodium chloride, or D5W –Do not use LR –Mix vial (500 mg) with 50 ml of diluent
A different Anxiolytic
BuSpar (buspirone) Class –Anti-anxiety, sedative hypnotic agent Indication –Anxiety Action –Binds to seratonin and dopamine receptors
Contraindications –Hypersensitivity Precautions –Pts receiving other antianxiety agents Adverse reactions, SE –dizziness, drowsiness, excitement, fatigue, H/A, insomnia, nervousness, weakness –Blurred vision, nasal congestion –Chest pain, palpitations, tachycardia
Route & dosage –10 – 15 mg PO tid How supplied –tablets
Paralytics
We’ll talk about Succinylcholine Vecuronium Tracrium
succinylcholine (Anectine) Class –Anticholinergic drug –Currare –Neuromuscular blockade Indications –Facilitate ET intubation
Action –Blocks acetylcholine receptors at neuromuscular junctions Contraindications –Hypersensitivity Precautions –Must be skilled in intubation
Adverse reactions, SE –Apnea –Arrhythmias –Malignant hyperthermia –Vomiting –Aspiration –Bradycardia –Hypertension –Concurrent administration with physostigmine intensifies paralysis
Route & dosage –1.5 mg/kg IV –Onset ~ 1 min. –Recovery, 4-6 min. –OR –3-4 mg/kg IM (max. dose 150 mg) –Onset 2 – 3 min.
How supplied –20 mg/ml in 10 ml vial Note: –Fasciculations start at eyelids, jaw – progresses to limbs, abdomen, then diaphragm and intercostal muscles. –Succs does NOT affect consciousness
Procedure –Preoxygenate –Prepare equipment –Atropine, 0.01 – 0.02 mg.kg (Peds or bradycardia) –Lidocaine 1 mg/kg (Head injury) –Valium or Versed –Succinylcholine, IV –Stop ventilations –Sellick’s maneuver until intubated –When fasciculations stop, check paralysis –Intubate! –If Succs starts to wear off, consider Vecuronium 0.1 mg/kg IVP; may repeat 0.05 mg/kg
Vecuronium Class –Non-depolarizing neuromuscular blocking agent Indications –Intubation Action –Binds to acetylcholine at motor receptors –Has little histamine release
Contraindications –None in the emergency setting Precautions –Increased blockade with bacitracin, lidocaine, verapamil Adverse reactions, SE –Malignant hyperthermia
Route & dosage –0.15 mg/kg IV –Onset: 2-3 minutes –Duration: 45 minutes How supplied
Tracrium Class –Nuromuscular blocking agent Indications –Intubation Action –Competes with acetylcholine for receptors at neuromuscular junction
Contraindications –Myasthenia gravis Precautions –Increased neuromuscular blockade with lidocaine, bacitracin, verapamil Adverse reactions, SE –Does NOT affect consciousness –arrhythmias
Route & dosage –0.5 mg/kg IV –Duration min. How supplied 50 mg/2 ml tubex or vial
Miscellaneous drugs
We’ll talk about Aspirin (again) Acetaminophen Activated charcoal Decadron D50 Diphenhydramine Epinephrine 1:1000 Inapsine Glucagon Glucose, Oral Heparin Haloperidol Ipecac Mannitol Solu-Medrol Oxytocin Phenergan Pralidoxime Streptokinase Thiamine Terbutaline
Aspirin (salicylate) Class –Antiplatelet agent First synthesized in mid-195h century Indication –Inflammatory disorders –Fever –TIA –MI
Action –Produces analgesia –Reduces inflammation and fever by inhibiting the production of prostoglandins –Decreases platelet aggregation
New Info! New England Journal of Medicine, 3/05 Men 50 y/o or more (no clinical evidence of coronary disease). ASA - Risk of MI 44% less No significant effect on risk of stroke and no effect on mortality from cardiovascular causes Women 65 y/o or more (no history of cardiovascular disease) ASA - No significant effect on risk of MI or risk of death from cardiovascular causes BUT 24% reduction in risk of ischemic stroke and 17% reduction in stroke risk overall
Conclusion of study Women < 65 y/o Reasonable to avoid prescribing low-dose aspirin (75-100mg) as a preventative measure for coronary disease Rx for stroke – left to pt and Dr
Contraindications –Hypersensitivity –Bleeding disorders or thrombocytopenia Precautions –GI bleeds or ulcers –Chronic alcohol use/abuse –Severe renal disease –Viral infections –Pregnancy
Adverse reactions, SE –GI bleeding –Anaphylaxis –Laryngeal edema –Dyspepsia, epigastric distress –Heartburn, nausea
Dosage & route Pain, Fever –PO, Rectal 325 – 500 mg q 3 h OR 325 – 650 mg q 4 h Not to exceed 4 g/day Cardiac chest pain –PO –81 mg x 3 chewable children's aspirin (243 mg) (UNLESS TAKING COUMADIN) How supplied Children's aspirin, 81 mg tablets Aspirin mg tablets
acetaminophen (Tylenol, APAP) Class –Antipyretic agent Indications –Mild pain –Fever Action –Inhibits synthesis of prostaglandins that serve as mediators of pain and fever –Has no significant anti-inflammatory properties
Contraindications –Hypersensitivity Precautions –Hepatic disease, renal disease Adverse reactions, SE –Hepatic failure
Route & dosage –PO (adults) 325 – 650 mg q 4 h –Rectal (children & infants) 80 mg q 4-6 h (infants 3 – 11 mo/ children 1 – 3 y/o) –How supplied 500 mg tablets 80 mg suppositories
activated charcoal (Acti- Char, Actidose) Class –Antidote Indications –Acute management of many poisonings following emesis/lavage Action –Binds drugs and chemicals in the GI tract
Contraindications –None known Precautions –Cyanide, corrosive, ethanol, petroleum, organic solvent or iron poisoning Adverse reactions, SE –Black stool
Route & dosage –Adults, PO – 25 – 100 g –Children 1-12 y/o, PO – g –Children < 1 y/o, PO 1 g/kg How supplied –Oral suspension with sorbitol, g in ml
dexamethasone sodium phosphate ( Decadron) Class: Short acting gluco-corticoid Indications: –Cerebral edema Action: suppresses inflammation
Contraindications: –Active untreated infections –Lactation Precautions –Chronic treatment –Children
Adverse reactions, SE –Peptic ulcers –Thromboembolism –Depression –Euphoria –Muscle wasting –Cushingoid appearance –Osteoporosis
Route & Dosages –10 – 100 mg IVP 10 mg initially, then 4 – 6 mg q 6 hr for 2-4 days then taper off over 5-7 days How supplied –10 mg/ml in 10 ml vial
Dextrose 50% (D50) Class: –Caloric agent (carbohydrate) Indication: –Hypoglycemia –Altered mentation when history unobtainable
Contraindications –Allergies to corn or corn products Precautions –Chronic alcoholics –Severe malnutrition
Adverse reactions, SE –None if blood glucose is less than 80 mg/dcL –Venous irritation Interactions: –Will alter requirements for insulin
How Supplied: –25 gm in 50 ml (50% dextrose) –12.5 gm in 50 ml (25% dextrose) Route & Dosage –IV: Adults ml of 50% solution slow infusion –IV: Infants and neonates: mg//kg/dose (as 25% dextrose):
Important note: Assess IV site frequently for extravasation; will cause tissue necrosis; if occurs, immed. Stop administ. Of drug Check for free blood return into syringe several times during administration
diphenhydramine (Benadryl) Class –Antidyskinetic, antihistamine, antitussive, anti-anxiety, sedative Indication –Relief of allergic symptoms –Anaphylaxis –Parkinsons disease –Dystonic reactions
Action –Antagonizes histamine effect –Does not bind to or inactivate histamine –Significant CNS depressant properties
Contraindications –Hypersensitivity –Acute asthmatic episode Precautions –Geriatrics –Severe liver disease
Adverse reactions, SE –Drowsiness –Anorexia –Dry mouth Route & dosage –10-50 mg IVP q 2-3 h How supplied –5 mg/ml in 10 ml preload or tubex
droperidol Inapsine Class: –Tranquilizer –Antiemetic Indications: –Sedation of combative patients to facilitate restraint –N/V
Action: –Similar to haloperidol, alters action of dopamine in CNS –Allays apprehension and provides a state of mental detachment and indifference while maintaining a state of reflex alertness.
Contraindications –Hypersensitivity –CNS depression –Severe liver disease or cardiac disease Precautions: –Hypotension may occur; have fluids available –Elderly
Adverse reactions, SE: Seizures Extrapyramidal reactions Hypotension tachycardia
Route & Dosage –Chemical restraint: – 10 mg IV slowly or IM (Usual dose 2.5 – 5.0 mg) Onset 3 – 10 min. Peak 30 min. Duration 2-4 hr. –Antiemetic 0.5 – 1 mg q 4 hr How supplied: –2.5 mg/ml in 2 ml preload
Epinephrine 1:1,000 Class –Adrenergic agonist –Vasopressor Indications –Management of reversible airway disease –Management of severe allergic reaction –Cardiac arrest
Action –Affects both beta 1 and beta 2 receptor sites –Has alpha 1 properties –Produces bronchodilation –Vasoconstriction –Inhibits release of mediators from mast cells
Contraindications –Hypersensitivity Precautions –Cardiac disease –hypertension
Adverse reactions, SE –Nervousness –Restlessness –Tremor –Angina –Arrhythmias –hypertension
Route & dosage –Anaphylactic/ Acute Asthma: – SQ 0.1 – 0.5 mg q min. How supplied –1 mg/ml in 1 mg tubex or preload
Glucagon Class: –Hormone Indications: –Acute management of severe hypoglycemia –Antidote to Beta-adrenergic blocking agent, calcium channel blockers
Action: –Stimulates hepatic production of glucose from glycogen stores –Relaxes smooth muscle of GI tract –Has positive inotropic and chronotropic effects
Contraindications: –Hypersensitivity to beef or pork protein Precautions: –pheochromocytoma
Adverse reactions & side effects: –N/V Drug Interactions –Large doses may inhance effects of Warfarin
Route & dosage: –Hypoglycemia: 1 mg IV –Antidote to Beta-blockers: 0.25 – 2 mg IV –Antidote to Calcium channel blockers: 2 mg IV How supplied: –1 mg glucagon in powder for injection with diluent of glycerin & sm. Amount of hydrochloric acid –Mix immediately before administration
Glucose, oral Class –Glycemic agent Indications –Hypoglycemia Action –Increases blood glucose
Contraindications –Loss of gag reflex Precautions –Decreased mentation Route & dosage –25 gm glucose, oral
Haloperidol (Haldol) Class –Antipsychotic agent Indications –Acute and chronic psychosis –Tourette’s syndrome –N/V from surgery or chemotherapy
Action –Alters effect of dopamine in CNS –Has anticholinergic, alpha-adrenergic blocking activity
Contraindications –Hypersensitivity Precautions –Geriatrics –Cardiac disease
Adverse reactions, SE –Seizures –Blurred vision, dry eyes –Constipation, dry mouth Route & dosage –0.5 – 5 mg IV How supplied –5 mg/ml in 1-ml tubex
Heparin Class –Anticoagulant Indication –Thromboembolic disorders Action –Potentiates the inhibitory effect of antithrombin
Contraindications –Hypersensitivity –Uncontrolled bleeding Precautions –Spinal cord or brain injury –Bleeding disorder –Women > 60 –Severe uncontrolled hypertension –Hemorrhagic stroke
Adverse reactions, SE –Bleeding –Anemia –Thrombocytopenia Route & dosage –Anticoagulation: 10,000 u IV followed by 5,000 – 10,000 u q 4-6 h –Continuous infusion: 20,000 – 40,000 u infused over 24 h How supplied –5,000 u/ml in vial
Ipecac Class –Antidote Indications –Induce vomiting in early mgmt of OD/poisoning Action –Stimulates chemoreceptor trigger zone in CNS and irritates gastric mucosa
Contraindications –Decreased mentation –Inebriated –Seizing patient Precautions –Pregnancy, lactation, children < 6 mo
Adverse reactions, SE –Myocarditis –Arrhythmias Route & dosage –PO (adults) ml may repeat at 15 ml in min –PO (children) 15 ml may repeat in min How supplied –Syrup; 15 ml or 30 ml containers
Mannitol 20% Class –Diuretic agent Indications –Increased ICP Action –Increases osmotic pressure of glomerular filtrate, inhibits reabsorption of water and electrolytes
Contraindications –Dehydration –Active intracranial bleeding Precautions –Pregnancy, lactation Adverse reactions, SE –Transient volume expansion
Route & dosage –IV, 1-2 g/kg slow IVP (over 30 min.) How supplied –2 g in 20 ml vial
methylprednisolone sodium succinate Solu-Medrol Class: –An intermediate-acting glucocorticoid –Anti-inflammatory –Immunosuppressant Indications: –Management of acute spinal cord injury –Used systemically for wide variety of chronic diseases, including: Inflammatory Allergic Autoimmune disorders
Action: –Stimulates the synthesis of enzymes needed to decrease the inflammatory response. Suppresses the immune system by reducing activity and volume of lymphatic system, and possibly reduces reactivity of tissue to antigen-antibody interactions
Contraindications –Active untreated infections –Systemic fungal infections –Don’t give live virus vaccines if pt. On methylprednisolone Precautions; –GI ulcerations –Renal disease –Hypertension
Adverse reactions and side effects: –Depression, euphoria –Hypertension –Nausea, anorexia –Decreased wound healing –Muscle wasting –osteoporosis
Route and dosage: –Spinal cord injury 30 mg/kg over 15 min. initially, then 45 min. later initiate continuous infusion of 5.4 mg/kg/hr for 23 hrs. How supplied –4 mg/ml, 10 mg/ml, 20 mg/ml vial
Oxytocin (Pitocin) Class –Agent used during pregnancy Indication –Induction of labor at term –Postpartum control of bleeding
Action –Stimulates smooth muscle –Has vasopressor and antidiuretic effects
Contraindications –Hypersensitivity Precautions –First and second stage of labor Adverse reactions, SE –Coma –Seizure –Intracranial hemorrhage –Fetal asphyxia –Painful contractions
Route & dosage –Induction of labor: 0.5 – 2 milliunits/min; increase by 1-2 milliunits/min q min to result –Postpartum hemorrhage 10 units infused at milliunits/min. How supplied –10 units/ml in 0.5 and 1 ml ampules –1 ml preloads
Promethazine (Phenergan) Class –Antiemetic agent –Antihistamine –Sedative hypnotic Indications –Preoperative sedation –Allergic conditions –Motion sickness
Action –Blocks histamine effects –Inhibitory effect on chemoreceptor trigger zone in medulla –Significant anticholinergic activity
Contraindications –Hypersensitivity Precautions –Hypertension –Sleep apnea –Epilepsy Adverse reactions, SE –Neuroleptic malignant syndrome –Confusion, disorientation, sedation
Route & dosage –Antihistamine: IV, IM, PR, 25 mg; repeat in 2 hr –Sedation: IV, IM, PR, mg How supplied –25 mg/ml in 1 ml ampules and 1 and 10 ml vials –Suppositories: 12.5 mg, 25 mg, 50 mg.
Pralidoxime Cl (Protopam Chloride, PAM) Class –Antidote –Anticholinesterase poisoning inhibitor Indication –After Atropine in severe cases of organophosphate poisoning Muscle twitching, paralysis Action –Reactivates cholinesterase
Contraindications –Inorganic phosphate poisoning Precautions –Tachycardia, laryngospasm, muscle rigidity with rapid infusion –Reduce dosage for pt with impaired renal function
Adverse reactions, SE –Dizziness, headache –Tachycardia –Nausea –Blurred vision
Route & dosage –1 – 2 g SLOW IV bolus –or IV infusion over min. after administration of Atropine –For infusion; mix 1 g in 250 ml NS How supplied –1 g/20 ml vial –Must be reconstituted with 20 ml sterile water
Streptokinase Class –Thrombolytic agent Indications –AMI < 12 h old –Pulmonary emboli –DVT Action –Convert plasminogen to plasmin; degrades fibrin
Contraindications –Active internal bleed –CVA –Recent CNS trauma or surgery –Severe uncontrolled hypertension Precautions –Surgery with in 10 days –Trauma –GI or GU bleeding –Recent arterial puncture
Adverse reactions, SE –Intracranial hemorrhage –GI bleeding –Retroperitoneal bleeding –GU tract bleeding –Anaphylaxis –Reperfusion arrhythmias
Route & dosage –MI: 1.5 million IU infused over 60 min. –DVT, PE 250,000 IU loading dose over 30 min., followed by 100,000 IU/h for 24 – 72 h
How supplied –Powder for injection; 250,000 IU/vial, or 1,500,000 IU/vial –Reconstitute with 5 ml NaCl or D5W (direct to side of vial) –Swirl gently; do not shake –Dilute further with NaCl for total volume of ml –(45 ml for MI –90 ml for DVT Administer through filter.
Thiamine Class –Vitamin B-1 Indications –Treatment of thiamine deficiency (Beriberi) –Prevention of Wernicke’s encephalopathy –Dietary supplement in pt with GI disease, alcoholism, or cirrhosis
Actions –Required for carbohydrate metabolism Distribution –Widely distributed Metabolism & excretion –Metabolized by the liver. –Excess amounts excreted unchanged by kidneys
Half-life –Unknown Contraindications –None in prehospital setting Precautions –Wernicke’s encephalopathy (condition may be worsened unless thiamine is administered before glucose.
Adverse reactions & side effects –None in prehospital setting Interactions –May inhance neuromuscular blocking agents
How supplied –100 mg/ml in 1 ml ampules and prefilled syringes Route and dosage –100 mg IVP (may be given IM)
Terbutaline Class –Bronchodilator Indication –Asthma –COPD –Preterm labor Action –Results in accumulation of cyclic adenosine monophosphate at beta-adrenergic receptors
Contraindications –Hypersensitivity Precautions –Near-term pregnancy Adverse reactions, SE –Paradoxical bronchospasm –Nervousness, restlessness, tremor
Route & dosage –Preterm labor: IV, 10 mcg/min., increase by 5 mcg/min until contractions stop. How supplied –1 mg/ml in 1 ml tubex