The Chinese University of Hong Kong Prince of Wales Hospital Role of Convalescence Serum In SARS Patients.

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The Chinese University of Hong Kong Prince of Wales Hospital Role of Convalescence Serum In SARS Patients

Rationale of Using Convalescence Serum Neutralization of hepatitis B by specific hepatitis B antibodies has been shown to prevent liver injury. SARS patient’s convalescence serum should contain neutralizing antibodies against corona virus. It should help patients with significant viraemia despite Ribavirin and prevent lung injury.

Selection Criteria for Serum Donor 1. Clinically recovered from SARS as evident by: Defeverence for 7 days. CXR improvement by 25% Oxygen independence 2. At least day 18 from symptom onset. 3. Negative for Hepatitis B & C, HIV, VDRL. 4. Informed consent All serum donors were confirmed to have antibodies against corona virus

Current Therapy in PWH RibavirinSteroids Suppress Viral Replication Suppress Inflammation

Current Therapy in PWH RibavirinSteroids Suppress Inflammation OR Suppress Viral Replication

Current Therapy in PWH RibavirinSteroids Suppress Inflammation Convalescence Serum More steroids OR Suppress Viral Replication

PWH Experience In PWH, Convalescence serum was given to over 70 patients whose condition deteriorated despite Ribavirin and high dose steroids.

Conclusion Preliminary data suggested that convalescence serum might be a treatment option for patients who deteriorated while on Ribavirin and high dose steroids. Preliminary data suggested that convalescence serum might be a treatment option for patients who deteriorated while on Ribavirin and high dose steroids. None of our patients experienced immediate adverse reaction. None of our patients experienced immediate adverse reaction. It is still an EXPERIMENTAL TREATMENT, and further studies are required to show whether it is more effective than other treatment options. It is still an EXPERIMENTAL TREATMENT, and further studies are required to show whether it is more effective than other treatment options. It is still too early to recommend it as standard therapy. It is still too early to recommend it as standard therapy.