CHMI 2227 - E.R. Gauthier, Ph.D. 1 CHMI 2227E Biochemistry I Proteins: - Levels of Protein Structure - Conformation of Peptide Group.

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Presentation transcript:

CHMI E.R. Gauthier, Ph.D. 1 CHMI 2227E Biochemistry I Proteins: - Levels of Protein Structure - Conformation of Peptide Group

CHMI E.R. Gauthier, Ph.D.2 Proteins: Levels of Protein Structure

CHMI E.R. Gauthier, Ph.D.3 Primary Structure

CHMI E.R. Gauthier, Ph.D.4 Secondary Structure

CHMI E.R. Gauthier, Ph.D.5 Tertiary Structure

CHMI E.R. Gauthier, Ph.D.6 Quaternary Structure

CHMI E.R. Gauthier, Ph.D.7 Proteins

CHMI E.R. Gauthier, Ph.D.8

9 Secondary Structure of Proteins

CHMI E.R. Gauthier, Ph.D.10 Conformation of the Peptide Group Peptide Group

CHMI E.R. Gauthier, Ph.D.11 Peptide bond has resonance structures! Peptide bond is shown as single C-N bond Peptide bond is shown as a double bond

CHMI E.R. Gauthier, Ph.D.12 Conformation of the peptide group Figure 3.25 Biochemistry 2001, Fifth Edition

CHMI E.R. Gauthier, Ph.D.13 Cis conformation of the peptide group R2 R1 CαCα CαCα CN O H

CHMI E.R. Gauthier, Ph.D.14 Trans conformation of the peptide group CαCα CαCα R1 R2 N H C O

CHMI E.R. Gauthier, Ph.D.15 Exceptions to the rule! Figure 3.26 Biochemistry 2001, Fifth Edition

CHMI E.R. Gauthier, Ph.D.16 Psi and Phi Angles

CHMI E.R. Gauthier, Ph.D.17 Psi and Phi Angles Peptide Bond

CHMI E.R. Gauthier, Ph.D.18 Psi and Phi Angles

CHMI E.R. Gauthier, Ph.D.19 Animation of Phi rotation Phi rotation

CHMI E.R. Gauthier, Ph.D.20 Animation of Psi rotation Psi rotation

CHMI E.R. Gauthier, Ph.D.21 Ramachandran Plot

CHMI E.R. Gauthier, Ph.D.22 Ramachandran Plot Figure 3.28 Biochemistry 2001, Fifth Edition