National Alliance for Medical Image Computing Core 3-1 Schizophrenia NA-MIC National Alliance for Medical Image Computing

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National Alliance for Medical Image Computing Core 3-1 Schizophrenia NA-MIC National Alliance for Medical Image Computing Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School Surgical Planning Laboratory, MRI Division, Department of Radiology Brigham & Women’s Hospital, Harvard Medical School

National Alliance for Medical Image Computing Data All the legacy data has been converted to one single file format, nrrd. Total of 188 morphological cases and 80 diffusion cases have been uploaded. Each case has a unique BIRN identifier. Information about diagnosis, data parameters and labels associated with Region of Interests (ROI) are on the BIRN site in the following Excel files: - morph-NAMIC.xls : Gives diagnosis, age, gender as well as the ROIs drawn for each morphological case. - morph-ROI-description.xls: Gives for each ROI set, the label corresponding to specific structures. - diffusion-NAMIC.xls: Gives diagnosis, age, gender, ROIs drawn and when existing, the corresponding morphological data ID number. - diffusion-ROI-description.xls: Gives or each ROI set, the label corresponding to specific structures.

National Alliance for Medical Image Computing Data Sets Already Uploaded MRI Data: Raw SPGR (124 slices of 1.5 mm thickness, voxel dimensions x x 1.5 mm): (N=26 SZ; N=28 AFF; N=29 Ctrl). ROIs -Amygdala-Hippocampus: (N=16 SZ and N=15 Ctrl). -STG: (N=17 SZ; N=16 AFF; N=18Ctrl). -MTG & ITG: (N=23 SZ; N=28 Ctrl). -Caudate: (N=15 SPD; N=14 Ctrl). -Insular Cortex & Temporal Pole: (N=26 SZ; N=28 AFF; N=29 Ctrl). DTI Data: Raw DWI data (8 images- six gradient directions plus 2 T2W, FOV 220mm, 256 x 256 image matrix, 4 mm slice thickness, 1 mm interslice distance). ROIs -Cingulum Bundle: (N=31 SZ; N=42 Ctrl). -Fornix: (N=24 SZ; N=31 Ctrl).

National Alliance for Medical Image Computing MRI Data

National Alliance for Medical Image Computing STG, MTG, and ITG Segmented ROIs (Onitsuka et al., AJP In Press)

National Alliance for Medical Image Computing (Kasai et al., Arch Gen Psychiatry, 2003) Insular Cortex and Temporal Pole ROI

National Alliance for Medical Image Computing Caudate Nucleus ROI (Koo et al., In Preparation)

National Alliance for Medical Image Computing DTI Data

National Alliance for Medical Image Computing Cingulum Bundle ROI was drawn on 8 consecutive slices. The fiber tract is much longer, however, but not easy to delineate. (Kubicki et al., 2003)

National Alliance for Medical Image Computing Fornix ROI drawn on 1slice perpendicular to the plane. (Kuroki et al., in press)

National Alliance for Medical Image Computing Rules for accessing and using the data IRB training (human subject’s protection) Data sharing (do not give data to other people) ROI data publication acknowledgement Grant acknowledgement -NIGHS/NI - U54 GM to Ron Kikinis -NIH - P41 RR13218 to Ron Kikinis; RO1 NS39335 to Stephan Maier; R01 MH to Martha Shenton; K05 MH to Martha Shenton; R01 MH to Robert McCarley; R03 MH to Marek Kubicki. -VA- Merit Awards to Martha Shenton and to Robert McCarley and a Research Enhancement Award Program (VA REAP) to Robert McCarley and to Martha Shenton.