Pharmtech Contract Services Offered by the Division of Pharmaceutical Technology

 Material characterisation  Crystal & Particle Design  Preformulation and Formulation  Process Development  Process Analytical Technology (PAT) solutions  Modelling and Data Analysis Pharmtech Contract Services Our aim is to offer efficient tailor-made solutions to meet the needs of our customers We offer services for:

Material characterisation  Crystal properites  API and Excipients  Formulations and products Pharmtech Contract Services We provide state-of-the-art characterization methods for physical and chemical analysis of solids during different steps of development. Crystal & Particle Design We offer screening methods to discover new solid forms including salts, cocrystals, or amorphous forms to provide enhanced drug substance properties.  Crystallisation research  Polymorph screening  Optimisation of crystallisation  Development of cocrystals  Amorphous forms

Preformulation services  Examination of physical properties  Powder characterization  Excipient compatibility  Process selection solutions Pharmtech Contract Services We can help you with you with preformulation stage to develop a drug substance into a quality drug product and guide you towards the optimal down-stream process-of-choice. Our expertise in formulation and product development enables the design of wide range of dosage forms including solids, semisolids, liquids, and lyophilised products Formulation expertise  Formulation optimisation  Development of immediate, modified and sustained release formulations  Bioavailability improvement of poorly soluble compounds by dosage form design  Protein and peptide products

Process Development  API Crystallisation  Milling  Mixing  Agglomeration  Compaction  Coating Pharmtech Contract Services We offer our expertise for optimization and scale-up of various manufacturing processes PAT solutions  In-line, on-line, off-line analysis  PAT techniques testing  Design Space establishment  Process intrumentation design  Risk analysis concepts Pharmtech will provide you with versatile process analytical solutions.

Modelling  Physical modelling of materials  Advanced process modelling solutions  Multivariate calibration models Pharmtech Contract Services Data Analysis  Design of experiments  Statistical analysis  Chemometric applications  Artificial Neural Network solutions  Data visualisation We have expertise in building physical process models and simulations that will help you understand and predict material and process behavior. Pharmtech will design your experiments, gather, model and transform your analytical and process data into useful information for efficient decision-making and drawing conclusions.

Analytical Techniques  X-Ray Powder Diffraction (XRPD)  Thermal analysis (DSC and thermomicroscopy)  Raman / NIR spectroscopy  IR spectroscopy / microscopy  Atomic force microscopy (AFM)  UV-vis-spectrophotometry  Solubility screening  Dissolution testing  Particle size analysis  Stability testing  Hygroscopicity studies  Mechanical testing  Various powder charactersation tools Pharmtech Contract Services

Process equipment  Multistage crystallizer  Batch Crystallisers  Blenders and mixers  Fluid-bed granulators  Extrusion-pelletisation  High shear granulator  Spray drier  Freeze drier  Fluid bed drying  Multi stage drier  Small scale ball mill  Rotary & single punch compactors  Emulsion processor Pharmtech Contract Services

Division of Pharmaceutical Technology Faculty of Pharmacy University of Helsinki Viikinkaari 5 E (P.O.Box 56) University of Helsinki Finland Pharmtech Contract Services