Bioinformatics and Genome Data Analysis Fredj Tekaia Institut Pasteur

Bioinformatics and Genome Data Analysis This advanced course aims at bringing multidisciplinary scientists around : a)What we learned from completely sequenced genomes. (Conferences: 1/2 time) b) Algorithms used in sequence and genome analysis (Lectures (1/4) and practical sessions (1/4)).

Day 1: Thursday - March 24 : : Introduction to Unix and perl programming Fredj Tekaia - Institut Pasteur Paris : Introduction to Useful Algorithms and multivariate analysis methods. Ahmed Rebai - Biotechnology Center Sfax Day 2: Friday - March 25: : Introduction to Molecular Biology data Odile Kalogeropoulos – Institut Pasteur Paris : Introduction to WEB resources in Bioinformatics and Genomes. Marie-Paule Lefranc – Montpellier II University

Day 3: Saturday - March 26: : conference : Genome annotation : What can we learn in bacterial biochemical reactions ? Georges Cohen – Institut Pasteur Paris 11H30 – 13H : conference : The human genome : impact in the biomedical domain. Sonia Abdelhak – Institut Pasteur Tunis Day 4: Sunday - March 27 : Social program: visit to ElDjem -

Day 5: Monday - March 28 : 9H – 12H : conference: How eukaryotic genomes evolve: the Yeast example. Bernard Dujon - Institut Pasteur Paris 14H - 18H : Theoretical and practical session : Substitution matrices – Algorithms for sequence comparisons ; Ahmed Rebai - Fredj Tekaia Day 6: Tuesday - March 29: 9H – 12H : conference : « Genomes of bacterial pathogenes and their diversity ». Philippe Glaser – Institut Pasteur Paris : Practical session: Large scale proteome comparisons. Fredj Tekaia - Ahmed Rebai

Day 7: Wednesday - March 30 : 9H – 13H : Conference : « Principles and methods for the analysis of genes and genomes sequences ». Edouard Yeramian – Institut Pasteur Paris : Motif detection - Multiple alignment. Ahmed Rebai - Fredj Tekaia Day 8: Thursday - March 31: 9H – 10H30 : Conference : « Transcriptional profiling of the hypha-to-yeast transition of the pathogenic fungus Paracoccidioides brasiliensis » Gustavo H. Goldman - Universidade de Sao Paulo, Brazil 11H- 12H30 «Large scale proteome comparisons». Fredj Tekaia

: « Molecular evolution and Phylogeny ». Fredj Tekaia - Ahmed Rebai Day 9: Friday - April 1 st : 9H-12H : conference : « Genome organization and genome evolution ». Georgio Bernardi - Stazione Zoologica Anton Dohrn – Napoli, Italy H: « Molecular Evolution and Phylogeny » Fredj Tekaia - Ahmed Rebai Day 10: Saturday - April 2 : 09H – 12H : conference : « Introduction to Structural Bioinformatics ». Michael Nilges – Institut Pasteur Paris H : Course evaluation and end.

Acknowledgements: The Institut Pasteur Paris ( Direction des Affaires Internationales (Mme Michèle Boccoz, Dr Jean-Luc Guesdon and Mme Leclerc). ICGEB ( Decio Ripandelli, Director, Administration and External Relations EMBO ( Mary Gannon, Programme Manager Kathy Oswald EMBO Courses and Workshops IUBMB (International Union of Biochemistry and Molecular Biology) ( Prof. Mary Osborn, President IUBMB Max Planck Institute for biophysical Chemistry, Göttingen,Germany. Prof. Jan Joep de Pont, Treasurer Radboud University Nijmegen, The Netherlands. ICRO (International Cell Research Organization) ( Prof. Georges Cohen, Institut Pasteur Paris Mme Claudine SCULLINO

Marie-Paule LEFRANC Université Montpellier II IMGT, the international ImMunoGeneTics informationsystem® Georgio Bernardi Stazione Zoologica Anton Dohrn; Villa Comunale8012, Napoli; Italy Sonia Abdelhak Institut Pasteur Tunis, Tunisia Ahmed Rebai Centre de Biotechnologie Sfax, Tunisia Gorges Cohen Bernard Dujon ( Odile Kalogeropoulos Philppe Glaser Michael Nilges Edouard Yeramian Fredj Tekaia Institut Pasteur Paris Gustavo Goldman Universidade de São Paulo, Ribeirão Preto, Brazil

Hamed Ben Dhia (President of the University) Ali Gargouri (Discussions and comments along the talks)