CTSA Consortiums: WESTRN James F. Holmes, MD, MPH Professor, Department of EM UC Davis School of Medicine

CTSA Consortia NIH wants CTSA consortia to develop Strategic Goal Committee 3: enhancing Consortium-Wide Collaborations –August 26, 2011 – –Implement research networking tools –Data available on people in each CTSA –Monitor collaborations 15 regional consortia listed on NIH CTSA website –

West Coast Emergency Services Translational Research Network (WESTRN) Oregon Health & Science University Harborview/University of Washington University of California at Davis San Francisco General Hospital/UC San Francisco Stanford University Denver Health/University of Colorado University of Utah University of California at Irvine University of Southern California University of New Mexico

WESTRN: Timeline February 2008: 1 st meeting of west coast CTSA leaders May 2008: 1 st meeting of EM investigators –7 sites Oct 2008: 2 nd meeting of EM investigators –Developed process for protocol submission/approval May 2009: 3 rd meeting and planned project July 2009: Protocol for 1 st project Feb 2010: Protocol for 2 nd project May 2012: 1 st meeting of the 10 current sites

WESTRN: Grants Funded: –RWJ Foundation: PI Newgard –CTSC site grants for initial project: multiple sites –CDC R01: PI Newgard –UC Davis CTSA site grant for 2nd project: PI Nishijima –NIGMS F32: PI – Jody Vogel Submitted: –NICHD R01 –NIGMS T32

WESTRN: Projects 1 st Project: Link prehospital trauma data with outcomes data –7 sites –Multiple projects within the database 2 nd Project: Variability of admission in patients with TBI –8 sites 3 rd Project: Validation of Denver trauma MOF score –Part of a F32 training grant –3 sites

WESTRN: Publications Abstracts: 12 at meetings from 2010 to 2013 –ACEP, SAEM, AAST, and American Heart Association – Resuscitation Symposium Manuscripts: 7 –Initial project: 6 (JACS, Annals of EM, AEM, J Trauma, Prehospital EM Care) –2 nd project: 1 (Annals of EM)

Thematic Special Interest Groups Consortia Self-developed consortia –10 listed on NIH website: Developing collaborations with existing networks, societies and organizations Identifying specific research proposals for collaboration Obtaining support from NIH Institutes and Centers, research institutions, and societies Organizing workshops and meetings with support from NIH ICs, research institutions, and NIH conference grants Meeting regularly in informal settings (teleconferences and at other pre-existing meetings) to share and collaborate

ECTRC: National EM CTSA research network National EM CTSA research network – care-researchershttps:// care-researchers May 2010 first meeting –Meetings each May at SAEM Massive numbers of patients within network Process, however, has been slow

Conclusion NIH wants consortiums among its CTSAs Facilitate studies needing large numbers of subjects Several existing consortia (see NIH website) –Regional and thematic Challenges with large consortia