HUMORAL AND CELL-MEDIATED IMMUNITY Lucija Klobučar, 2nd year 2013/2014 Mentor: A. Žmegač Horvat
IMMUNITY Lat. immunitas – freedom from Immune system
LEVELS OF IMMUNE RESPONSE INNATE IMMUNITY SPECIFIC IMMUNITY external barriers phagocytic cells humoral cell-mediated IF NOT! ANTIGEN
EXAMPLE
CELLS OF SPECIFIC IMMUNITY
ANTIGEN-PRESENTING CELLS Macrophages (bacteria) Dendritic cells (viruses) B lymphocytes (toxins) In tissues Phagocyte and degrade Display on cell surface Enter lymph In lymph nodes Interaction with T helper cells DECISION cytokines, type of presenting cell Humoral or cell-mediated immune response
HUMORAL OR CELL MEDIATED IMMUNE RESPONSE? BACTERIA B cells HUMORAL RESPONSE VIRUSES Cytotoxic T cells CELL- MEDIATED RESPONSE
INTERACTION OF T HELPER CELL AND RESTING HUMORAL IMMUNITY B cells – develop in bone marrow – blood, lymph, lymph nodes Primary follicle with resting B lymphocytes Secondary follicle with activated B lymphocytes Plasma cells Memory B cells Secrete immunoglobulins Circulate INTERACTION OF T HELPER CELL AND RESTING B LYMPHOCYTES Antigen-presenting cell – lymph node – interaction with T helper cells
IMMUNOGLOBULINS Five classes – IgA, IgD, IgE, IgG, IgM Lymph node – circulation – inflamed tissue – recognition of antigen – activation of complement system Opsonizing antigen Enhancing inflammation
CELL-MEDIATED IMMUNITY T cells – development in bone marrow and thymus Selection Differentiation T helper cells T cytotoxic cells Circulate
CELL-MEDIATED IMMUNITY Antigen-presenting cell – lymph node – interaction with T helper cells Resting cytotoxic T cells INTERACTION OF T HELPER CELL AND RESTING CYTOTOXIC T CELL Activated and multiplied cytotoxic T cells enter blood and lymph In inflamed tissue Recognition and lysis of cells infected with viruses
REFERENCES Roitt, Delves Roitt's Essential Immunology, 10th edition Andreis, Batinić, Čulo, Grčević, Lukinović-Škudar, Marušić, Taradi, Višnjić Imunologija, 7. izdanje