HUMORAL AND CELL-MEDIATED IMMUNITY Lucija Klobučar, 2nd year 2013/2014 Mentor: A. Žmegač Horvat

IMMUNITY Lat. immunitas – freedom from Immune system

LEVELS OF IMMUNE RESPONSE INNATE IMMUNITY SPECIFIC IMMUNITY external barriers phagocytic cells humoral cell-mediated IF NOT! ANTIGEN

EXAMPLE

CELLS OF SPECIFIC IMMUNITY

ANTIGEN-PRESENTING CELLS Macrophages (bacteria) Dendritic cells (viruses) B lymphocytes (toxins) In tissues Phagocyte and degrade Display on cell surface Enter lymph In lymph nodes Interaction with T helper cells DECISION cytokines, type of presenting cell Humoral or cell-mediated immune response

HUMORAL OR CELL MEDIATED IMMUNE RESPONSE? BACTERIA B cells HUMORAL RESPONSE VIRUSES Cytotoxic T cells CELL- MEDIATED RESPONSE

INTERACTION OF T HELPER CELL AND RESTING HUMORAL IMMUNITY B cells – develop in bone marrow – blood, lymph, lymph nodes Primary follicle with resting B lymphocytes Secondary follicle with activated B lymphocytes Plasma cells Memory B cells Secrete immunoglobulins Circulate INTERACTION OF T HELPER CELL AND RESTING B LYMPHOCYTES Antigen-presenting cell – lymph node – interaction with T helper cells

IMMUNOGLOBULINS Five classes – IgA, IgD, IgE, IgG, IgM Lymph node – circulation – inflamed tissue – recognition of antigen – activation of complement system Opsonizing antigen Enhancing inflammation

CELL-MEDIATED IMMUNITY T cells – development in bone marrow and thymus Selection Differentiation T helper cells T cytotoxic cells Circulate

CELL-MEDIATED IMMUNITY Antigen-presenting cell – lymph node – interaction with T helper cells Resting cytotoxic T cells INTERACTION OF T HELPER CELL AND RESTING CYTOTOXIC T CELL Activated and multiplied cytotoxic T cells enter blood and lymph In inflamed tissue Recognition and lysis of cells infected with viruses

REFERENCES Roitt, Delves Roitt's Essential Immunology, 10th edition Andreis, Batinić, Čulo, Grčević, Lukinović-Škudar, Marušić, Taradi, Višnjić Imunologija, 7. izdanje