HUMORAL AND CELL-MEDIATED IMMUNITY

Slides:



Advertisements
Similar presentations
Immune System.
Advertisements

Defense Against Infectious Disease
The lymphatic system and immunity
Chapter15 B cell mediated immune response. B cells mediated immune response Humoral immunity(HI) or antibody mediated immunity: The total immunological.
NOTES: Specific Defenses / Immunity (UNIT 9 part 3)
Ch. 43 The Immune System.
The Immune System. First lines of defense: Skin Mucus Stomach acid Digestive enzymes.
Chapter 15 Innate and Adaptive Immunity
IMMUNITY.
Chapter 15 Innate and Adaptive Immunity
Lecture #19 Date _________
The Immune System 1.The Innate System 2.The Adaptive System.
Acquired Immunity Defends Against Infection of Body Cells and Fluids By: Jonah Harrington, Josh Yi.
Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 67 Review of the Immune System.
Immune System. System of chemicals, white blood cells, and tissues that protect the body against pathogens (disease causing microorganisms) Immune system.
Lymphatic System.
Immunology NON-SPECIFIC RESPONSES – SPECIFIC RESPONSES –
The Immune system Role: protect body against pathogens
MCB 135E: Discussion November 15-19, Immunology Development Function Important Aspects Bacterial Infection Complement Viral Infection Classes of.
Specific Immune Defense. Antigens Antibody-generator, Non-self, Large molecules Properties: ◦1. Immunogenicity ◦2. Reactivity Antigenic determinant or.
Immunity The ability to defend against infectious agents, foreign cells, and cancer cells.
Design of immune system Immune system Self/non-self recognition The state of protection from infectious disease 自我非我 Memory Acceptance vs rejection 疫苗.
Chapter 43: The Immune System. Lymphocytes: Specialized White Blood Cells : Two Types: B Lymphocytes T Lymphocytes.
Immunity Innate and Adaptive Immunity Cells of the Immune System
 The system that keeps us alive and healthy – we call it the immune system.  Pathogens – microorganisms that produce diseases in us. (Bacteria, viruses,
Body’s Defenses. Passive Formation of antibodies To the fetus thru the placenta, thru breast milk, thru administration of plasma (artificial) Active.
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Chapter 14 Specific Immunity (adaptive immunity)
Immune System (immunus = to be free) primary defense against disease- causing organisms.
Specific Immunity Destroy specific antigens that invade the body.
Immune System “Do I still have to go to school doc?”
Immune System Chapter 43 ~ The Body’s Defenses. Lines of Defense Nonspecific Defense Mechanisms……
Immunogenetics chapter 22 select topics pp
Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings About this Chapter  Anatomy and function of immune system  Response to different.
Chapter 24 ~ The Immune System. Animal immune system.
CHAPTER 3: Adaptive Immunity (specific body defense system)
The Immune System 2 1. Adaptive Specific immunity (acquired) = the ability of the body to defend itself against specific invading agents such as bacteria,
Immunology Innate - Adaptive Immunity Specificity Memory Tolerance.
Highlights of Immune System. Topic Outline Overview of the Immune System 1 st and 2 nd lines of Defense The Immune System  B cells  The antibody & antibody.
Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 13 The Immune Response.
Specific Immune Responses How the Immune System Handles Specific Antigens.
Chapter 6 Adaptive Immunity “third line of defense”  Develops more slowly  Specific  Memory.
Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings The Immune System, Part II Medgar Evers College, CUNY Spring 2014, Bio 261 Prof.
___________DEFENSES of the HOST: THE IMMUNE RESPONSE
The Immune System Dr. Jena Hamra.
Chapter 43 ~ The Body’s Defenses. Lines of Defense.
Chapter 17 Immune response. Two types of resistance. Innate resistance and acquired resistance. Innate resistance – one is born with the resistance. All.
Immune system Haixu Tang School of Informatics. Human lymphoid organs.
ANTIBODIES Agents of Immunity - A Guide for Teachers - Prepared by Johanna Mancini for Immunology Montreal August 2008.
Major Events in the Local Inflammatory Response.
Immunity. Body Defenses First line - barriers Skin and mucous membranes Flushing action –Antimicrobial substances Lysozyme, acids, salts, normal microbiota.
Innate and adaptive immunity The immune system has various mechanisms to eliminate pathogens that get past physical barriers. These include both innate.
11. B Cell Recognition and Response to Antigens 王 家 鑫王 家 鑫.
Humoral immunity Antibody structure Antibody diversity
Lecture 7 Immunology Cells of adaptive immunity
The Immune System Ch th ed Campbell’s Biology.
Specific Defenses of the Host Adaptive or Specific Immunity.
Immunology Introduction to Immune system. Learning outcome You will be able to understand, at a fundamental level, the STRUCTURES and FUNCTIONS of cell.
The Immune System. Protects our bodies from pathogens – disease causing agents May be bacteria, viruses, protists, fungi, etc Response could be nonspecific.
Immune response Pathophysiology.
IMMUNITY ..
The Basics of Immunology
The Adaptive Immune Response
CELL MEDIATED IMMUNITY
Chapter 14 Immune System.
NOTES: Specific Defenses / Immunity (UNIT 10 part 3)
Chapter 17 Immune response.
The lymphatic system and immunity
The Lymphatic System Pages
Immunogenetics chapter 22 select topics pp
Presentation transcript:

HUMORAL AND CELL-MEDIATED IMMUNITY Lucija Klobučar, 2nd year 2013/2014 Mentor: A. Žmegač Horvat

IMMUNITY Lat. immunitas – freedom from Immune system

LEVELS OF IMMUNE RESPONSE INNATE IMMUNITY SPECIFIC IMMUNITY external barriers phagocytic cells humoral cell-mediated IF NOT! ANTIGEN

EXAMPLE

CELLS OF SPECIFIC IMMUNITY

ANTIGEN-PRESENTING CELLS Macrophages (bacteria) Dendritic cells (viruses) B lymphocytes (toxins) In tissues Phagocyte and degrade Display on cell surface Enter lymph In lymph nodes Interaction with T helper cells DECISION cytokines, type of presenting cell Humoral or cell-mediated immune response

HUMORAL OR CELL MEDIATED IMMUNE RESPONSE? BACTERIA B cells HUMORAL RESPONSE VIRUSES Cytotoxic T cells CELL- MEDIATED RESPONSE

INTERACTION OF T HELPER CELL AND RESTING HUMORAL IMMUNITY B cells – develop in bone marrow – blood, lymph, lymph nodes Primary follicle with resting B lymphocytes Secondary follicle with activated B lymphocytes Plasma cells Memory B cells Secrete immunoglobulins Circulate INTERACTION OF T HELPER CELL AND RESTING B LYMPHOCYTES Antigen-presenting cell – lymph node – interaction with T helper cells

IMMUNOGLOBULINS Five classes – IgA, IgD, IgE, IgG, IgM Lymph node – circulation – inflamed tissue – recognition of antigen – activation of complement system Opsonizing antigen Enhancing inflammation

CELL-MEDIATED IMMUNITY T cells – development in bone marrow and thymus Selection Differentiation T helper cells T cytotoxic cells Circulate

CELL-MEDIATED IMMUNITY Antigen-presenting cell – lymph node – interaction with T helper cells Resting cytotoxic T cells INTERACTION OF T HELPER CELL AND RESTING CYTOTOXIC T CELL Activated and multiplied cytotoxic T cells enter blood and lymph In inflamed tissue Recognition and lysis of cells infected with viruses

REFERENCES Roitt, Delves Roitt's Essential Immunology, 10th edition Andreis, Batinić, Čulo, Grčević, Lukinović-Škudar, Marušić, Taradi, Višnjić Imunologija, 7. izdanje