Intraoperative Visualization of White Matter Tracts During Brain Tumor Resection Haytham Elhawary, Ph.D Postdoctoral Research Fellow March 19 th 2010

2 Intraoperative DTI Increased survival is associated to increased tumor resection in both high and low grade gliomas Minimize neurological deficits, so functional and anatomical information is required: fMRI, DTI, T1w, T2w Relation between white matter tracts, normal brain tissue and tumor Objective is to develop a system that can allow visualization of white matter tracts in real-time during the intervention Objectives

3 Intraoperative DTI

4 Tracked surgical tool from a navigation system sent to 3D Slicer VVLink and OpenIGTLink used to transfer data from Brainlab system to 3D Slicer Tool tip location used to create a fiducial point to seed DTI dataset using tractography. White matter tracts are visualized only in the surgical tool tip region Methods

5 Haytham Elhawary; Haiying Liu; Pratik Patel; Isaiah Norton; Laura Rigolo; Xenophon Papademetris; Nobuhiko Hata; Alexandra J. Golby, “Intra-operative Real-time Querying of White Matter Tracts during Frameless Stereotactic Neuronavigation”, Neurosurgery, under review Intraoperative DTI

6 Haytham Elhawary; Haiying Liu; Pratik Patel; Isaiah Norton; Laura Rigolo; Xenophon Papademetris; Nobuhiko Hata; Alexandra J. Golby, “Intra-operative Real-time Querying of White Matter Tracts during Frameless Stereotactic Neuronavigation”, Neurosurgery, under review Intraoperative DTI

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8 Haytham Elhawary; Haiying Liu; Pratik Patel; Isaiah Norton; Laura Rigolo; Xenophon Papademetris; Nobuhiko Hata; Alexandra J. Golby, “Intra-operative Real-time Querying of White Matter Tracts during Frameless Stereotactic Neuronavigation”, Neurosurgery, under review Intraoperative DTI

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10 Intraoperative DTI

11 Intraoperative DTI Overlay DTI visualization on to the microscope view (although there are some problems) Eliminate the BioImage Suite connection to reduce points of failure Be able to pre-select only relevant clinical white mater tracts for visualization Future Work