Copyright © 2009 Pearson Education, Inc. Extensions of Mendelian Genetics Chapter 4 Lecture Concepts of Genetics Tenth Edition
Copyright © 2009 Pearson Education, Inc. 4.1Alleles Alter Phenotypes in Different Ways Wild type Loss of function Null Gain of function New alleles are produced by mutation
Copyright © 2009 Pearson Education, Inc. 4.2Geneticists Use a Variety of Symbols for Alleles
Copyright © 2009 Pearson Education, Inc. 4.3Neither Allele Is Dominant In Incomplete, or Partial, Dominance
Copyright © 2009 Pearson Education, Inc. Figure 4.1
Copyright © 2009 Pearson Education, Inc. 4.4In Codominance, the Influence of Both Alleles in a Heterozygote Is Clearly Evident (There’s no “blending” of phenotypes)
Copyright © 2009 Pearson Education, Inc. 4.5Multiple Alleles of a Gene May Exist in a Population 4.5.1The ABO Blood Groups 4.5.2The A and B Antigens
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Figure 4.2
Copyright © 2009 Pearson Education, Inc. 4.5Multiple Alleles of a Gene May Exist in a Population 4.5.3The Bombay Phenotype
Copyright © 2009 Pearson Education, Inc. Figure 4.3
Copyright © 2009 Pearson Education, Inc. 4.5Multiple Alleles of a Gene May Exist in a Population 4.5.4The white Locus in Drosophila More than 100 alleles
Copyright © 2009 Pearson Education, Inc. 4.1
Copyright © 2009 Pearson Education, Inc. 4.6Lethal Alleles Represent Essential Genes 4.6.1Recessive Lethal Mutations
Copyright © 2009 Pearson Education, Inc. Figure 4-4 Copyright © 2006 Pearson Prentice Hall, Inc. ?
Copyright © 2009 Pearson Education, Inc. 4.6Lethal Alleles Represent Essential Genes 4.6.2Dominant Lethal Mutations
Copyright © 2009 Pearson Education, Inc. 4.7Combinations of Two Gene Pairs With Two Modes of Inheritance Modify the 9:3:3:1 Ratio
Copyright © 2009 Pearson Education, Inc. Figure 4.5
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4.8Phenotypes Are Often Affected by More Than One Gene 4.8.1Epistasis
Copyright © 2009 Pearson Education, Inc. Figure 4.6
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Figure 4.7
Copyright © 2009 Pearson Education, Inc. Figure 4.8
Copyright © 2009 Pearson Education, Inc. Figure 4.9
Copyright © 2009 Pearson Education, Inc. 4.9Complementation Analysis Can Determine if Two Mutations Causing a Similar Phenotype are Alleles
Copyright © 2009 Pearson Education, Inc. Figure 4.11
Copyright © 2009 Pearson Education, Inc. 4.10Expression of a Single Gene May Have Multiple Effects Pleiotropy
Copyright © 2009 Pearson Education, Inc. 4.11X-Linkage Describes Genes on the X Chromosome X-Linkage in Drosophila
Copyright © 2009 Pearson Education, Inc. Figure 4.12
Copyright © 2009 Pearson Education, Inc. Figure 4.13
Copyright © 2009 Pearson Education, Inc. 4.11X-Linkage Describes Genes on the X Chromosome X-Linkage in Humans
Copyright © 2009 Pearson Education, Inc. Table 4.3
Copyright © 2009 Pearson Education, Inc. Figure 4.14
Copyright © 2009 Pearson Education, Inc. 4.12In Sex-Limited and Sex-Influenced Inheritance, an Individual’s Sex Influences the Phenotype
Copyright © 2009 Pearson Education, Inc. Figure 4.15
Copyright © 2009 Pearson Education, Inc. Figure 4.16
Copyright © 2009 Pearson Education, Inc. 4.13Genetic Background and the Environment May Alter Phenotypic Expression Penetrance and Expressivity
Copyright © 2009 Pearson Education, Inc. Figure 4.17
Copyright © 2009 Pearson Education, Inc. 4.13Genetic Background and the Environment May Alter Phenotypic Expression Genetic Background: Suppression and Position Effects
Copyright © 2009 Pearson Education, Inc. Figure 4.18
Copyright © 2009 Pearson Education, Inc. 4.13Genetic Background and the Environment May Alter Phenotypic Expression Temperature Effects—An Introduction to Conditional Mutations
Copyright © 2009 Pearson Education, Inc. Figure 4.19
Copyright © 2009 Pearson Education, Inc. 4.13Genetic Background and the Environment May Alter Phenotypic Expression Nutritional Effects Onset of Genetic Expression Genetic Anticipation Genomic (Parental) Imprinting
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