ANSYS FLUENT for Brain Research: Cranio-spinal system

Slides:

Advertisements

Similar presentations

1 Detecting Subtle Changes in Structure Chris Rorden –Diffusion Tensor Imaging Measuring white matter integrity Tractography and analysis.

Advertisements

National Alliance for Medical Image Computing Diffusion Weighted MRI.

Neuroradiology Natasha Wehrli, MS4 University of Pennsylvania School of Medicine.

A new insight in interpreting brain tumor edema Aristotelis S. Filippidis M.D., Christos Tsonidis M.D. Ph.D. 1 Medical school, University of Thessaly,

Interpretation of CT Brain- neuro surgical prospective

Hydrocephalus. Background What is hydrocephalus? Abnormal accumulation of cerebrospinal fluid in the ventricles of the brain Results in elevated intracranial.

Camino and DTI-TK: Advanced Diffusion MRI Pipeline for Traumatic Brain Injury Gary Hui Zhang, PhD Microstructure Imaging Group Centre for Medical Image.

Neuroradiology Dr Mohamed El Safwany, MD. Intended Learning Outcomes  The student should be able to understand role of medical imaging in the evaluation.

Self-propelled motion of a fluid droplet under chemical reaction Shunsuke Yabunaka 1, Takao Ohta 1, Natsuhiko Yoshinaga 2 1)Department of physics, Kyoto.

Meninges and CSF Dr. K. Sivapalan.

Class grades 3 Quizzes Clinical Notebooks Due: 2 Exams

The Danish National Research Foundation’s Center of Functionally Integrative Neuroscience Aarhus University / Aarhus University Hospital Diffusion weighted.

Diffusion Tensor MRI And Fiber Tacking Presented By: Eng. Inas Yassine.

Modeling Intracranial Fluid Flows and Volumes During Traumatic Brain Injury to Better Understand Pressure Dynamics W. Wakeland 1 J. McNames 2 M. Aboy 2.

The Central Nervous System Central nervous system – the brain and spinal cord Directional terms unique to the CNS Rostral – toward the nose Caudal – toward.

Convective Diffusion (ubiquitious). Basic Convective Diffusion Model.

Public Health Julie C. Chapman, PsyD Director of Neuroscience War Related Illness & Injury Study Center Veterans Affairs Medical Center, Washington, DC.

Design of a Cranial Vascular Mechanics Model Sean S. Kohles, PhD Director, Kohles Bioengineering, Portland, OR; Adjunct Associate Professor, Mechanical.

Brain and Spinal Cord (CNS) Anatomy Support structures –(bone) –meninges –cerebrospinal fluid (CSF) Protective structure –blood-brain barrier General.

Noninvasive Measurement of Intracranial Pressure by MRI (MR-ICP) Overview Noam Alperin, PhD Physiologic Imaging and Modeling Lab Department of Radiology.

Hemodynamics and Factors Affecting Blood Flow Amir Golnabi ENGS 166 Spring 2008.

Hydrocephalus By Bayindir Citak “Water Brain”. Hydrocephalus Hydrocephalus is- The causes are- It affects someone by- The current treatment is- Works.

Hydrocephalus. Definition Hydrocephalus is the result of buildup of CSF in the ventricles of the brain Fig Hydrocephalus and Ventriculoperitoneal Shunts.

1 Chapter 9 Cerebrospinal Fluid Professor A. S. Alhomida Disclaimer The texts, tables, figures and images contained in this course presentation (BCH 376)

FRACTALS IN NEUROSCIENCE Bio and Brain Engineering in KAIST, Son HyunJin.

CEREBROSPINAL FLUID (CSF) AND THE BLOOD-BRAIN BARRIER (BBB)

Central Nervous System Physiology Dr Tony Morrissey Speciality Doctor Anaesthetics 25/09/13.

Imaging Anatomy of the CNS

Computational Model of Water Movement in Plant Root Growth Zone Brandy Wiegers University of California, Davis Angela Cheer Wendy Silk 2005 World Conference.

Brain Tidbit I: Nourishment to the brain

Organization of the Nervous System Overview of the Central (CNS), Peripheral (PNS), Autonomic (ANS), Enteric (ENS) Nervous Systems.

Cerebrospinal Fluid-Tissue Interactions in the Human Brain

Physiological Systems Modeling and Simulation Federica Caselli University of Rome “Tor Vergata” A.A. 2011/2012.

What We Should Know About Hydrocephalus Luiza da Silva Lopes Ribeirão Preto 2012.

Computational Protein Topographics for Health Improvement Jie Liang, Ph.D. Bioengineering Prime Grant Support: National Science Foundation Career Award,

WPA Neuroimaging. WPA Basic Principles of Brain Imaging Some technique is used to measure a signal in the brain (e.g., the degree to which an xray beam.

Computational Fluid Dynamics Applied to the Analysis of 10-mm Hydrocyclone Solids Separation Performance S. A. Grady, M. M. Abdullah, and G. D. Wesson.

LPPD NSF REU Site, University of Illinois-Chicago, Summer 2006 Intracranial Blood Pressure and Brain Vasculature Advisors: Professor Linninger Dr. Michalis.

Flowing Matter – COST Action MP1305, , Sofia NUMERICAL ANALYSIS OF THE STENOSIS EFFECTS ON THE BLOOD FLOW IN THE COMMON CAROTID ARTERY BIFURCATION.

WARM UP 3/13 1. Make 6 multiple choice questions from any of the notes from this chapter.

Revision Imaging Procedure 3 Dr Mohamed El Safwany, MD.

Laboratory for Product and Process Design Computer Assisted Design of Transport Processes in the Human Brain Laboratory for Product and Process Design,

Modeling Drug Delivery in the Rhesus Monkey Koula Quirk, RET Fellow 2010 RET Mentor: Dr. Andreas Linninger Department of Bioengineering, University of.

Quote of the Week: "I started reading about people of great accomplishment... and it dawned on me suddenly that the person who has the most to do with.

Normal Pressure Hydrocephalus

Sirasa Iambamrung Intern/Mentor GT Advisor: Dr. Edward Ahn Dr. Kiehl.

Role of the Bidomain Model of Cardiac Tissue in the Dynamics of Phase Singularities Jianfeng Lv and Sima Setayeshgar Department of Physics, Indiana University,

CFD characterization and thrombogenicity analysis of a prototypal polymeric aortic valve Filippo Piatti 1, Matteo Selmi 1, Alessandra Pelosi 1, Thomas.

Date of download: 7/8/2016 Copyright © ASME. All rights reserved. From: Voxelized Model of Brain Infusion That Accounts for Small Feature Fissures: Comparison.

Intratumoral topography of CNS gliomas revealed by diffusion tensor imaging: correlations with tumor volume and grade A. Jakab 1, P. Molnár 2, M. Emri.

Diapositiva 1 XIX SYMPOSIUM NEURORADIOLOGICUM – Bologna 4-9 October 2010 PHASE CONTRAST MR AS NON- INVASIVE TOOL IN THE DIAGNOSIS OF BENIGN INTRACRANIAL.

Date of download: 9/18/2016 Copyright © ASME. All rights reserved. From: Computational Modeling of the Mechanical Behavior of the Cerebrospinal Fluid System.

Sponge: Set up Cornell Notes on pg. 19 Topic: 11.2: Ventricles- CSF and TBI Essential Question: None. 2.1 Atoms, Ions, and Molecules 11.2:Ventricles-CSF-

Meninges & CSF and Ventricular system

ME 7980 Cardiovascular Biofluid Mechanics

Imaging Anatomy of the CNS

Date of download: 10/24/2017 Copyright © ASME. All rights reserved.

Date of download: 10/30/2017 Copyright © ASME. All rights reserved.

Richard Smith, Kathleen Myers, John Ravits, Robert Bowser

Get out work from yesterday

Recovery of Osmolarity in the Extracellular Fluid and the Brain during an Acute Hypo-osmotic Challenge Victoria Hunt with Dr. Qain-Quan Sun Department.

Patient 1. Patient 1. A, Sagittal T1-weighted image (600/8/2) shows a Chiari I malformation, with tonsillar herniation to the mid-C2 level and a pointed.

NPH on T2-weighted fast spin-echo, axial images.

Ventricles Ventricles irregularly shaped spaces deep within the brain

Normal Brain CT Scan & Hydocephalus

How is the CNS protected from Injuries?

Notes Ch. 11A Nervous System II

Molecular Therapy - Methods & Clinical Development

Presentation transcript:

ANSYS FLUENT for Brain Research: Cranio-spinal system Cranium Spinal canal Medical Image Mathematical Model

ANSYS FLUENT for Brain Research: Hydrocephalus Normal Hydrocephalic

ANSYS FLUENT for Brain Research Application Intracranial Dynamics

ANSYS FLUENT Application: Intracranial dynamics Medical Imaging 1st Principles: Math/Physics Computer Science

ANSYS FLUENT Application: Intracranial dynamics Third ventricle 3rd ventricle Aqueduct 4th ventricle Pontine cistern

ANSYS FLUENT Application: Intracranial dynamics Normal Velocity [m/s] Pressure [Pa] Linninger, A.A., M. Xenos, D.C. Zhu, M.R. Somayaji, S. Kondapalli, and R.D. Penn. Cerebrospinal fluid flow in the normal and hydrocephalic human brain. IEEE Trans. Biomed. Eng. 54:291-302, 2007.

ANSYS FLUENT Application: Intracranial dynamics (mm/s) 3rd ventricle Aqueduct 4th ventricle Pontine cistern

ANSYS FLUENT Application: Intracranial dynamics Definition of Symbols/Abbreviations LV: lateral ventricle SAS: subarachnoid space V4: fourth ventricle CCJ: cranio-cervical junction

ANSYS FLUENT Application: Intracranial dynamics—Conclusions Pressure gradients in the brain remain small (<1mmHg) Blood flow and vasculature expansion driving force for pulsatile CSF motion

ANSYS FLUENT for Brain Research Application Drug Delivery

ANSYS FLUENT Application: Drug delivery to the human brain Drug transport—porous brain parenchyma Effective Diffusion Tensor of Growth Factor (GDNF) near the Putamen Diffusion flux in anisotropic tissue: Apparent water diffusion tensor in human brain from diffusion tensor imaging (DTI) Axial view Motivation: Validate invasive techniques for clinical practice Geometrical Challenge: Reconstruction of brain anatomy from images Physiological Challenge: Quantify brain anisotropy and heterogeneity from DTI Drug Transport Challenge: Predict spatio-temporal drug distribution in 3d Treatment Challenge: Propose optimal catheter positioning and CED parameters

ANSYS FLUENT Application: Drug delivery to the human brain

ANSYS FLUENT Application: Drug delivery to the human brain Molecular weight = 27,000 kg/kmol; Flow rate = 4µl/min ; X0 = 3.7·10-3 mol/l, no reaction high low Axial slices

ANSYS FLUENT for Brain Research Drug Delivery Additional Applications

ANSYS FLUENT Application: Drug distribution & catheter placement GDNF (neurotrophic factor) concentration field over time mol/l Thalamus injection Injection into gray matter Week #1 Week #2 Week #4 Internal capsule injection Injection into white matter mol/l Week #1 Week #2 Week #4 A. Linninger, M.R. Somayaji, L. Zhang, M.S. Hariharan and R. Penn. Rigorous Mathematical Modeling Techniques for Optimal Delivery of Macromolecules to the Brain. IEEE Transaction on Biomedical Engineering, 55 (9): 2303-2313, 2008.

ANSYS FLUENT Application: Drug distribution & catheter design Flow direction at week 3 Concentration field over time low high Week #1 Week #2 Week #3

ANSYS FLUENT Application: References Linninger, A.A., M.R. Somayaji, T. Erickson, X. Guo, and R.D. Penn. Computational methods for predicting drug transport in anisotropic and heterogeneous brain tissue. Journal of Biomechanics. 41:2176-2187, 2008. Linninger, A.A., M.R. Somayaji, M. Mekarski, and L. Zhang. Prediction of convection-enhanced drug delivery to the human brain. J Theor Biol. 250:125-138, 2008. Linninger, A.A., M.R. Somayaji, L. Zhang, M.S. Hariharan, and R.D. Penn. Rigorous Mathematical Modeling Techniques for Optimal Delivery of Macromolecules to the Brain. Biomedical Engineering, IEEE Transactions on. 55:2303-2313, 2008. Linninger, A.A., B. Sweetman, and R. Penn. Normal and hydrocephalic brain dynamics: the role of reduced cerebrospinal fluid reabsorption in ventricular enlargement. Ann. Biomed. Eng. 37:1434-47, 2009. Linninger, A.A., M. Xenos, B. Sweetman, S. Ponkshe, X. Guo, and R. Penn. A mathematical model of blood, cerebrospinal fluid and brain dynamics. J. Math. Biol. 59:729-59, 2009. Linninger, A.A., M. Xenos, D.C. Zhu, M.R. Somayaji, S. Kondapalli, and R.D. Penn. Cerebrospinal fluid flow in the normal and hydrocephalic human brain. IEEE Trans. Biomed. Eng. 54:291-302, 2007. Morrison, P.F., R.R. Lonser and E.H. Oldfield, “Convective delivery of glial cell line-derived neurotrophic factor in the human putamen”, J Neurosurg, vol.107, pp. 74-83, Jul, 2007. Salvatore, M.F., Y. Ai, B. Fischer, A.M. Zhang, R.C. Grondin, Z. Zhang, G.A. Gerhardt, D.M. Gash, “Point source concentration of GDNF may explain failure of phase II clinical trial”, Experimental Neurology, vol. 202, pp. 497-505, 2006.