Effects of childhood exposure to paternal alcoholism on substance use disorders in adolescents and young adults A.E. Duncan,Q. Fu, K.K. Bucholz, J.F. Scherrer,

Slides:

Advertisements

Similar presentations

Early Use of Alcohol or Cigarettes in Relation to Alcohol and Nicotine Use Disorders: A Retrospective Co-twin Control Study Qiang Fu, a M.D., Ph.D. Andrew.

Advertisements

P3 Event-Related Potential Amplitude and the Risk for Disinhibitory Behavior Disorders W.G. Iacono University of Minnesota.

Is Caregiver Depression Associated with Children’s ADHD Symptoms and Overall Functioning? Randi Scott SUMR Final Presentation August 07, 2008.

Panic Symptoms, Cigarette Smoking and Drinking in Adolescent Female Twins Michele Pergadia, Andrew C. Heath, Kathleen K. Bucholz, Elliot C. Nelson, Christina.

Early Alcohol Use as a Risk Factor for Drug Use and Dependence.

Sean D. Kristjansson Andrew C. Heath Andrey P. Anokhin Substance Use Among Older Adolescents: A Latent Class Analysis.

ADHD and initiation of drinking and drinking to intoxication in girls: Is there an association? Valerie S. Knopik, Pamela A.F. Madden, and Andrew C. Heath.

Accutane-Psychiatric Disorders A Pharmacoepidemiological Safety Assessment Robert C. Nelson, PhD RCN Associates, Inc. Annapolis, MD.

EARLY CIGARETTE USE BEHAVIORS AND ALCOHOL Pamela A.F. Madden, Ph.D.*, Michele Pergadia, Ph.D., Michael Lynskey, Ph.D., and Andrew C. Heath, D.Phil. Washington.

Acknowledgements Methods Veena A. Satyanarayana PhD, Susan Bradford BSEd, Arbi Ben Abdallah DES, Linda B. Cottler PhD, MPH, Washington University School.

CHILDREN’S MENTAL HEALTH PROBLEMS IN RHODE ISLAND: THE PREVALENCE AND RISK FACTORS Hanna Kim, PhD and Samara Viner-Brown, MS Rhode Island Department of.

Journal Club Alcohol and Health: Current Evidence November–December 2004.

Genetic Epidemiological Perspectives on Alcohol Use and Dependence Society for Neuroscience: Henri Begleiter Symposium 11/2/07 Kenneth S Kendler MD Virginia.

Psychiatric Comorbidity of Smoking and Nicotine Dependence: An Epidemiologic Perspective Naomi Breslau, Ph.D. Department of Epidemiology Michigan State.

Factors Related to Adolescent Alcohol Use Progression Matos TD, Robles RR, Reyes JC, Calderón J, Colón HM, Negrón-Ayala JL CENTER FOR ADDICTION STUDIES,

ALCOHOL USE DISORDERS AND TEENAGE SEXUAL INTERCOURSE A.E. Duncan, J.F. Scherrer, K.K. Bucholz, W.R. True and T. Jacob.

Social Network Drinking Outweighs Family History in the Development of Alcohol Dependence in Adults Vivia V. McCutcheon, PhD, Christina Lessov-Schlaggar,

Suicidal thoughts and behaviors in African-American and European- American youth in a community family study of alcoholism Ellen L. Edens, Anne L. Glowinski,

Offspring of Alcoholism Discordant Twins Study

Author Author Author PH251 Date Is Father Absence Early in Life Associated with Age at Menarche?

1 Generalizability of Religious Affiliation Effects on Alcohol Outcomes Randy Haber, Ph.D. VA Palo Alto Health Care System Acknowledgments: VA Health Care.

Candidate Gene Studies in Substance-Dependent Adolescents, their Siblings, and Controls S. E. Young, A. Smolen, M. C. Stallings, R. P. Corley, T. J. Crowley.

THE RELATIONSHIP BETWEEN BMI AND SUICIDALITY IN YOUNG ADULT WOMEN Alexis E. Duncan, Pamela A.F. Madden, and Andrew C. Heath Washington University Department.

THE RELATIONSHIP BETWEEN ADOLESCENT/YOUNG ADULT BMI AND SUBSEQUENT NON- PROBLEM AND PROBLEM ALCOHOL USE Alexis E. Duncan, Kathleen Keenan Bucholz, Pamela.

Does prenatal exposure modify the response to first use of alcohol and tobacco? Valerie S. Knopik, Kathleen K. Bucholz, Michele L. Pergadia, Andrew C.

Parental Alcohol Problems and Early Sexual Debut in Young Adult Women Claudia Gambrah, Alexis E. Duncan, Andrew C. Heath.

Validity of the Lifetime Drinking History: A Comparison of Retrospective and Prospective Quantity-Frequency Measures Laura B. Koenig, Ph.D. Theodore Jacob,

MARC Project 4: Australian Children of Alcoholic Female Twins.

Copyright restrictions may apply Household, Family, and Child Risk Factors After an Investigation for Suspected Child Maltreatment: A Missed Opportunity.

1 Relationship Between Prenatal Maternal Smoking and Drinking and Subtypes of ADHD in Two Population Based Samples of Missouri Twins R.J. Neuman A.C. Health.

Jeffrey F. Scherrer, Kathleen K. Bucholz, Pamela A.F. Madden, Andrew C. Heath, Theodore Jacob, Hong Xian The Contribution of Parent, Sibling and Friend.

Jeffrey F. Scherrer (1,2); Hong Xian (2); Andrew C. Heath (1,2); Theodore Jacob (1); William R. True (1,3), Kathleen K. Bucholz (1,2) Smoking in Offspring.

Consistency in Reports of Early Alcohol Use Supported by grants AA009022, AA007728, & AA (NIAAA); HD (NICHD) and DA18660 (NIDA) Carolyn E.

Typologies of Alcohol Dependent Cocaine-using Women Enrolled in a Community-based HIV Intervention Victoria A. Osborne, Ph.D., MSW*, Linda B. Cottler,

Comorbidity between Alcohol Dependence (AD) and Nicotine Dependence (ND): The Genetic Contributions from Antisocial Personality Disorder (ASPD) and Major.

Jeffrey F. Scherrer 1,2, Hong Xian 2,3, Julia D. Grant 1, Kathleen K. Bucholz 1 1 Dept. of Psychiatry, Washington University School of Medicine, St. Louis,

Spousal Associations for Alcohol Dependence and Educational Attainment Andrew Williams University of North Carolina Support from NIH Grants: AA07728, AA11998,

Self-Reported Childhood Abuse and Illicit Drug Abuse/Dependence E.C. Nelson; A.C. Heath; K.K. Bucholz; P.A.F. Madden; M.T. Lynskey, D.J. Statham; and N.G.

DRINKING MOTIVES AND CONTINUING TO DRINK IN ADOLESCENT TWIN BOYS: INVESTIGATING THE MODERATING EFFECTS OF ANXIETY SENSITIVITY Michele L. Pergadia, Andrew.

MARC Project 4: Australian Children of Alcoholic Female Twins Wendy S. Slutske, Valerie S. Knopik, Theodore Jacob, Michael T. Lynskey, & Anne Glowinski.

Predicting Offspring Conduct Disorder Using Parental Alcohol and Drug Dependence Paul T. Korte, B.A. J. Randolph Haber, Ph.D.

The Contribution of Self-Reported Childhood Abuse to the Onset of Alcohol-related Outcomes E.C. Nelson; A.C. Heath; K.K. Bucholz; P.A.F. Madden; D.J. Statham;

FIRST REACTIONS TO CIGARETTES AND ALCOHOL Pamela Madden, Ph.D. Andrew C. Heath, D.Phil. Kathleen Bucholz, Ph.D. Christina Lessov, Ph.D. Michele Pergadia,

Prospective Cohort Study of Thai Children SECONDHAND SMOKING IN PREGNANT WOMEN AND TIME OF THE FIRST TOOTH ERUPTION DIEN HOA ANH VU PhD Student – Faculty.

Neta Peleg-Oren, Eric F. Wagner, Staci Leon Morris 1 Paternal Alcohol Use, Maternal Warmth and Psychosocial Outcomes among Adolescents Participating in.

Evidence for Specificity of Transmission of Alcohol and Nicotine Dependence in an Offspring of Twins Sample Heather E Volk MPH, Jeffrey F Scherrer PhD,

LIFETIME COMORBIDITY OF ALCOHOL DEPENDENCE AND BULIMIA NERVOSA IN WOMEN Alexis Duncan * 1,2,3, Rosalind Neuman 1,2, Victor Hesselbrock 5, John Kramer 4,

Personality and Substance Use Behaviors Associations of the Big Five traits with adolescent substance use, demonstrated through analysis of the MOFAM data.

Associations Among Parental Alcohol Problems, Trauma, and Depression in a Twin Sample Vivia V. McCutcheon, MSW; Andrew C. Heath, D.Phil.; Elliot C. Nelson,

Adolescent Mothers & Their Babies’ Fathers: Predictors of Paternal Involvement and Coparenting Christina B. Gee, Ph.D. Psychology Department

Studying the transition to college: A new prospective study IMPACTS Supported by National Institute on Alcohol Abuse and Alcoholism Grant 4 R37 AA

Predicting Stage Transitions in the Development of Nicotine Dependence Carolyn E. Sartor, Hong Xian, Jeffrey F. Scherrer, Michael Lynskey, William True,

Genetic and Environmental Influences on Perceived Peer Alcohol Use During Adolescence Julia D. Grant 1, Kathleen K. Bucholz 1, Pamela A.F. Madden 1, Wendy.

Vivia V. McCutcheon, Howard J. Edenburg, John R. Kramer, Kathleen K. Bucholz 9 th Annual Guze Symposium St. Louis, MO February 19, 2009 Gender Differences.

Do genetic influences on abuse and dependence overlap? Explorations using cannabis and alcohol diagnoses. Julia D. Grant and Kathleen K. Bucholz Washington.

Familial Aggregation of Suicide Explained by Cluster B Traits: A Three-Group Family Study of Suicide Controlling for Major Depressive Disorder kongdi.

Transitions in Conjoint Alcohol and Tobacco Use among Adolescents Kristina M. Jackson University of Missouri, Columbia & Missouri Alcoholism Research Center.

Jeffrey F. Scherrer (1,2); Hong Xian (2); Andrew C. Heath (1,2); Theodore Jacob (1); William R. True (1,3), Kathleen K. Bucholz (1,2) Are the Measured.

Race, tobacco, and alcohol in a high risk family study Alexis Duncan, Wilma Calvert, Collins Lewis, and Kathleen Bucholz.

Abstract A longitudinal study designed to follow children of alcohol and drug dependent fathers from adolescence into adulthood RISK began in 1993 and.

Minnesota Twin Family Study. The Study  An ongoing population-based, investigation of same-sex twin children and their parents that examines the origination.

Introduction  Schizophrenia ↓ Neuro-developmental Disorder ↕ Pathogenesis in gestation and early childhood ↕ Further research is needed.

Youth on the Street Maltreatment, Mental Health & Addiction Thornton, T., Goldstein, A., Tonmyr, L. & Vadneau, A.

Gender Specific Associations Between Parental Risk Factors and Trauma-Related Psychological Symptoms Among Adolescents Jamara A. Tuttle, MSW 1,2,Terry.

Research on the relationship between childhood sleep problems and substance use in adolescents and young adults is limited. This knowledge gap has been.

Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder,

Parental Alcoholism and Adolescent Depression?

Copyright © 2008 American Medical Association. All rights reserved.

The Effects of Self-Esteem and Optimism on Alcohol Use in

Copyright © 2010 American Medical Association. All rights reserved.

Presentation transcript:

Effects of childhood exposure to paternal alcoholism on substance use disorders in adolescents and young adults A.E. Duncan,Q. Fu, K.K. Bucholz, J.F. Scherrer, T. Jacob, and W.R. True

OBJECTIVE To determine whether exposure to paternal alcoholism in the first 12 years of life is related to the development of substance use disorders

METHODS COA Study Fathers –1464 twin fathers sampled from the Vietnam Era Twin Registry –All had at least 1 child yrs old in 2000 –Twin pairs either concordant or discordant for alcohol dependence. Controls were non-alcoholic twin pairs Mothers –1,000 biological and/or rearing (i.e. lived regularly with child between ages 6 and 13) mother identified, 864 interviewed –Mothers asked to give permission to interview offspring Offspring –Mothers identified and gave permission for 1487 offspring to be interviewed. 1,270 offspring of 730 fathers were interviewed.

Assessment Domains Twin fathers’ alcohol lifetime Dx and zygosity obtained from ‘92 data (Tsuang and Lyons). 1,464 twin fathers sampled with 84% response rate (n=1176). Updated lifetime drinking history (LDH) collected from twin fathers by telephone interview. Mothers and offspring were interviewed by telephone and completed a questionnaire by mail to provide: –Telephone interview: Alcohol abuse, dependence, lifetime drinking history (offspring only), substance use/abuse, psychopathology (depression, anxiety, conduct disorder, oppositional defiant disorder, attention deficit/hyperactivity disorder) –Mail questionnaire: psychosocial variables (family & relationship quality, peers, school attendance, work environment, personality, drinking expectancies, etc.)

Data Analysis Latent class analysis was done using LCAP ( to group children of alcoholics by pattern of exposure to paternal alcoholism STATA was used to develop Cox Proportional Hazards models for risk of developing alcohol abuse/dependence, marijuana abuse/dependence and nicotine dependence and adjust for confounding variables and familial clustering

Latent Class Analysis Statistical method for uncovering patterns or structure in multivariate categorical data (like factor analysis for categorical data) Defines “clusters” or “classes” of cases that share similar characteristics Cases placed in clusters based upon membership probabilities Cox Proportional Hazards Models Survival analysis – accounts for the possibility that some subjects have not yet had time to develop the outcome Assumption that risk remains constant over time Hazard ratios can be thought of like odds ratios

LCA for child exposure to paternal alcoholism COA’s only (n=618) Father’s lifetime drinking history (LDH) matched to child’s lifetime Binary variables created indicating whether or not father met criteria for alcohol abuse or dependence during each of the first 12 years of the child’s life 4 class solution was selected

Child exposure to paternal alcoholism LCA – 4 class solution

Characteristics of the sample Latent class for exposure to paternal alcoholism Non- alcoholicNoneChronicEarlyLate N (%)652 (51.3)264 (20.8)195 (15.4)114 (9.0)45 (3.5) % Male Age: yrs yrs yrs

Proportion of offspring with fathers with lifetime psychiatric and drug use disorders DSM-III-R Disorder Latent class for exposure to paternal alcoholism Non- alcoholicNoneChronicEarlyLate N (%) 652 (51.3)264 (20.8)195 (15.4)114 (9.0)45 (3.5) Drug abuse or dependence ASPD Depression

Offspring substance use disorders and other psychopathology Latent class for exposure to paternal alcoholism Father not alcoholicNoneChronicEarlyLate N (%)652 (51.3)264 (20.8)195 (15.4)114 (9.0)45 (3.5) Alcohol abuse/ dependence Marijuana abuse/ dependence Nicotine Dependence Conduct Disorder ODD Depression Social Phobia *Dependence Only

Cox proportional hazards models for alcohol abuse/dependence – adjusting for gender, age cohort, and clustering Hazard Ratios (95% CI) * NoneChronicEarlyLate All 1.10 (0.81, 1.51) 1.44 (1.09, 1.90) 1.93 (1.31, 2.84) 1.57 (1.00, 2.46) Male 1.20 (0.81, 1.79) 1.46 (1.01, 2.09) 1.45 (0.84, 2.51) 1.80 (1.06, 3.05) Female 1.03 (0.64, 1.66) 1.46 (0.95, 2.24) 2.35 (1.39, 3.98) 1.19 (0.46, 3.09) *Comparison group: children of non-alcoholics

Cox proportional hazards models for marijuana abuse/dependence – adjusting for gender, age cohort, and clustering Hazard Ratios (95% CI)* NoneChronicEarlyLate All 1.21 (0.79, 1.84) 1.06 (0.65, 1.72) 1.62 (0.94, 2.82) 0.65 (0.24, 1.75) Males 1.63 (0.99, 2.66) 0.99 (0.54, 1.80) 1.17 (0.50, 2.71) 0.70 (0.22, 2.22) Females 0.69 (0.31, 1.52) 1.19 (0.59, 2.40) 2.03 (0.96, 4.31) 0.54 (0.07, 4.00) *Comparison group: children of non-alcoholics

Cox proportional hazards models for nicotine dependence – adjusting for gender, age cohort, and clustering Hazard Ratios (95% CI)* NoneChronicEarlyLate All 1.34 (0.68, 1.21) 1.15 (0.82, 2.17) 1.90 (1.07, 3.38) 0.86 (0.30, 2.49) Male 1.22 (0.62, 2.39) 1.20 (0.61, 2.36) 2.07 (0.42, 2.72) 0.34 (0.04, 5.79) Female 1.49 (0.75, 2.96) 1.12 (0.53, 2.37) 2.79 (1.31, 5.94) 1.66 (0.48, 5.79) *Comparison group: children of non-alcoholics

Cox proportional hazards models for alcohol abuse/dependence before and after adjusting for father psychopathology* Hazard Ratios (95% CI)** NoneChronicEarlyLate Males Before 1.20 (0.81, 1.79) 1.46 (1.01, 2.09) 1.45 (0.84, 2.51) 1.80 (1.06, 3.05) After 1.24 (0.82, 1.87) 1.45 (0.99, 2.11) 1.46 (0.84, 2.55) 1.71 (0.95, 3.07) Females Before 1.03 (0.64, 1.66) 1.46 (0.95, 2.24) 2.35 (1.39, 3.98) 1.19 (0.46, 3.09) After 0.96 (0.59, 1.57) 1.39 (0.90, 2.14) 2.26 (1.32, 3.87) 1.14 (0.44, 2.96) *drug abuse/dependence, major depression and ASPD ** Comparison group: children of non-alcoholics

Cox proportional hazards models for marijuana abuse/dependence before and after adjusting for father psychopathology* Hazard Ratios (95% CI) NoneChronicEarlyLate Males Before 1.63 (0.99, 2.66) 0.99 (0.54, 1.80) 1.17 (0.50, 2.71) 0.70 (0.22, 2.22) After 1.39 (0.82, 2.36) 0.87 (0.48, 1.60) 0.92 (0.39, 2.16) 0.59 (0.19, 1.37) Females Before 0.69 (0.31, 1.52) 1.19 (0.59, 2.40) 2.03 (0.96, 4.31) 0.54 (0.07, 4.00) After 0.62 (0.28, 1.38) 1.15 (0.56, 2.34) 2.01 (0.92, 4.36) 0.45 (0.06, 3.28) *drug abuse/dependence, major depression and ASPD ** Comparison group: children of non-alcoholics

Cox proportional hazards models for nicotine dependence before and after adjusting for father psychopathology* Hazard Ratios (95% CI) NoneChronicEarlyLate Males Before 1.22 (0.62, 2.39) 1.20 (0.61, 2.36) 2.07 (0.42, 2.72) 0.34 (0.04, 5.79) After 1.15 (0.60, 2.22) 1.02 (0.53, 1.98) 0.95 (0.35, 2.52) 0.26 (0.03, 2.19) Females Before 1.49 (0.75, 2.96) 1.12 (0.53, 2.37) 2.79 (1.31, 5.94) 1.66 (0.48, 5.79) After 1.30 (0.65, 2.62) 0.99 (0.47, 2.07) 2.55 (1.15, 5.66) 1.68 (0.49, 5.78) *drug abuse/dependence, major depression and ASPD ** Comparison group: children of non-alcoholics

CONCLUSIONS After adjusting for age cohort and father drug abuse/dependence, depression, and ASPD, exposure to paternal alcoholism in the first 12 years of life is associated with over a 2-fold risk of alcohol abuse/ dependence and nicotine dependence in females, when exposure to paternal alcoholism is early in the first 12 years of life.

Future analyses Explore the role of maternal alcoholism, depression, and ASPD symptoms Consider the role of paternal alcoholism severity Devise a variable for child contact with father and use as a covariate Examine the role of exposure during the teen years

We would like to acknowledge:... the Support of NIAAA for Grant P50-AA11998 to Andrew Heath for the Missouri Alcoholism Research Center Grant R01-AA11667 to Theodore Jacob for Adult Children of Alcoholism Discordant Twins, and Grant R01-AA11822 to William True for Adolescent Children of Alcoholics: A Twin Family Design.