LASER Doppler analysis of blood flow in ischemic diabetic mouse hindlimbs injected with PBMCs or vehicle on theday of femoral artery ligation Ola Awad,

Slides:



Advertisements
Similar presentations
Date of download: 7/7/2016 Copyright © The American College of Cardiology. All rights reserved. From: Sustained Release of Erythropoietin Using Biodegradable.
Advertisements

Assessment of mouse hind limb endothelial function by measuring femoral artery blood flow responses  Chao-Hung Wang, MD, Kuo-Ti Chen, MS, Hsiu-Fu Mei,
Impaired angiogenic potency of bone marrow cells from patients with advanced age, anemia, and renal failure  Tao-Sheng Li, MD, PhD, Masayuki Kubo, PhD,
by Hideto Sano, Kohei Hosokawa, Hiroyasu Kidoya, and Nobuyuki Takakura
Vascular endothelial growth factor-C derived from CD11b+ cells induces therapeutic improvements in a murine model of hind limb ischemia  Go Kuwahara,
Activation of EphB4 by ephrinB2‐Fc prevents aberrant angiogenesis
Platelet-derived growth factor C promotes revascularization in ischemic limbs of diabetic mice  Junji Moriya, MD, PhD, Xiumin Wu, PhD, Jose Zavala-Solorio,
High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury 
Therapeutic angiogenesis using autologous bone marrow stromal cells: improved blood flow in a chronic limb ischemia model  Abdulaziz Al-Khaldi, MD, Hilal.
In vivo electroporation of constitutively expressed HIF-1α plasmid DNA improves neovascularization in a mouse model of limb ischemia  Geoffrey O. Ouma,
Ulka Sachdev, MD, Xiangdong Cui, MS, Edith Tzeng, MD 
Elevation of hemopexin-like fragment of matrix metalloproteinase-2 tissue levels inhibits ischemic wound healing and angiogenesis  April E. Nedeau, MD,
The bone marrow-derived endothelial progenitor cell response is impaired in delayed wound healing from ischemia  Stephen M. Bauer, MD, Lee J. Goldstein,
by Sergio Rey, Weibo Luo, Larissa A. Shimoda, and Gregg L. Semenza
Gale Tang, MD, David N. Charo, Rong Wang, PhD, Israel F
Angiogenic properties of human placenta-derived adherent cells and efficacy in hindlimb ischemia  Aleksandar Francki, PhD, Kristen Labazzo, PhD, Shuyang.
Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin–restricted miRNA antagonists of miR-27 by Jennifer A. Young, Ka.
Robert A. Brenes, MD, Caroline C
Ryan M. McEnaney, MD, Ankur Shukla, MD, Michael C
Shock wave treatment induces angiogenesis and mobilizes endogenous CD31/CD34- positive endothelial cells in a hindlimb ischemia model: Implications for.
Ulka Sachdev, MD, Xiangdong Cui, MS, Edith Tzeng, MD 
Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. AT-3ovadim.
Cellular and molecular mechanism regulating blood flow recovery in acute versus gradual femoral artery occlusion are distinct in the mouse  Yagai Yang,
Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model  Noriko Takahashi, MD, Rei.
Effects of SC144 on in vivo ovarian tumor.
Fig. 8. mRIPO elicits neutrophil influx followed by DC and T cell infiltration into tumors. mRIPO elicits neutrophil influx followed by DC and T cell infiltration.
Simvastatin pretreatment enhances ischemia-induced neovascularization and blood flow recovery in streptozotocin-treated mice  Po-Hsun Huang, MD, PhD,
Angiogenesis and vasculogenesis: Inducing the growth of new blood vessels and wound healing by stimulation of bone marrow–derived progenitor cell mobilization.
Galit Ankri-Eliahoo, PhD, Kevin Weitz, BS, Timothy C. Cox, PhD, Gale L
Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease  Alessandra Bitto, MD, Francesca Polito,
Impaired angiogenic potency of bone marrow cells from patients with advanced age, anemia, and renal failure  Tao-Sheng Li, MD, PhD, Masayuki Kubo, PhD,
Simultaneous application of basic fibroblast growth factor and hepatocyte growth factor to enhance the blood vessels formation  Akira Marui, MD, Akihiro.
EphB4 stimulation prevents aberrant angiogenesis by uncontrolled adenoviral VEGF delivery both in normal and in ischemic muscle EphB4 stimulation prevents.
Figure 1 The abundance of CD3+ T cells and their subtypes are significantly affected by FTY and DMF treatment The abundance of CD3+ T cells and their subtypes.
Salvage angiogenesis induced by adenovirus-mediated gene transfer of vascular endothelial growth factor protects against ischemic vascular occlusion 
Efficacy of fragmin/protamine microparticles containing fibroblast growth factor-2 (F/P MPs/FGF-2) to induce collateral vessels in a rabbit model of hindlimb.
Biochemically engineered stromal cell-derived factor 1-alpha analog increases perfusion in the ischemic hind limb  Bryan B. Edwards, BE, Alexander S.
GM-CSF–producing γδT cells are involved in the development of EAM
Assessment of mouse hind limb endothelial function by measuring femoral artery blood flow responses  Chao-Hung Wang, MD, Kuo-Ti Chen, MS, Hsiu-Fu Mei,
Fig. 7 BRD0705 impairs colony formation in AML cell lines and patient cells and shows in vivo efficacy in multiple AML mouse models. BRD0705 impairs colony.
Histological changes in mouse colons after DSS treatment.
Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density  Joseph M. McClung, PhD, Timothy.
Kinetics of CXC chemokine appearance after endotoxin injection.
Volume 17, Issue 12, Pages (December 2009)
Jessica L. Ungerleider et al. BTS 2016;1:32-44
IBD development correlates with peripheral T cell activation in DNR mice. IBD development correlates with peripheral T cell activation in DNR mice. (A)
EphB4 stimulation does not cause vessel regression
Volume 16, Issue 12, Pages (December 2008)
Figure 4. p38α mitogen-activated protein kinase (MAPK) blockade reduces interstitial volume in obstructed kidneys but does not reduce the number of infiltrating.
Volume 19, Issue 4, Pages (April 2011)
Fig. 5 Treatment with an OX40 agonist antibody of 3-week-old HBVtgRag−/− mice or mice with chronic HBV disease results in an altered immune response to.
PD-L1 expression is maintained on NCMs under inflammatory conditions and PD-L1+NCMs are found in TLOs. PD-L1 expression is maintained on NCMs under inflammatory.
Pax7IresCreER/+-mediated Hif1a deletion accelerates muscle regeneration. Pax7IresCreER/+-mediated Hif1a deletion accelerates muscle regeneration. (A-D)
Interactions of neutrophil-derived OSM with gp130-containing receptors on endothelial cells enhance P-selectin–dependent rolling in mouse postcapillary.
1018-NT-β-cell clusters protect mice from STZ-induced diabetes.
SYK activity is required for anti-IgM–induced CD86 expression.
GLP-1 and gastrin combination therapy restores normoglycemia in NOD mice. GLP-1 and gastrin combination therapy restores normoglycemia in NOD mice. Beginning.
Reversal of diabetic impairments in the blood flow recovery and neovascularization of ischemic areas by ANG-(1-7): A: Representative laser Doppler images.
CD151 effects on mammary cell morphology and adhesion.
Loss of Phb2 in β-cells induces development of diabetes over a 3-week period in β-Phb2−/− mice. Loss of Phb2 in β-cells induces development of diabetes.
In situ hybridization. In situ hybridization. The expression pattern of VEGF-R2, angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2), the angiopoietin receptor.
Overexpression of IL-27 upregulates expression of multiple IR by T cells in vivo. Overexpression of IL-27 upregulates expression of multiple IR by T cells.
Fig. 3 Treating vaccinated mice with OVA-releasing scaffolds enhances angiogenesis and muscle regeneration following ischemic injury. Treating vaccinated.
Volume 22, Issue 7, Pages (July 2014)
SY-1425 induces maturation in RARA-high AML
Depletion of Gr-1+ neutrophils by systemic anti-Gr-1 treatment prevents exacerbated neurodegeneration in RAG1-KO mice. Depletion of Gr-1+ neutrophils by.
Anti-CD40 activates TAMs and recruits inflammatory monocytes.
A, cell number was assessed 96 hours after exposure to indicated treatment in indicated cell models. A, cell number was assessed 96 hours after exposure.
Galit Ankri-Eliahoo, PhD, Kevin Weitz, BS, Timothy C. Cox, PhD, Gale L
Effect of HDC on the ROS production in mouse lungs after melanoma cell inoculation. Effect of HDC on the ROS production in mouse lungs after melanoma cell.
Presentation transcript:

LASER Doppler analysis of blood flow in ischemic diabetic mouse hindlimbs injected with PBMCs or vehicle on theday of femoral artery ligation Ola Awad, et al. ATVB 2006;26:

Inflammatory Assessment of Ischemic Muscle Ola Awad, et al. ATVB 2006;26:

Mouse muscle histology Ola Awad, et al. ATVB 2006;26:

CD34 + PBMC- treated ischemic muscle Ola Awad, et al. ATVB 2006;26:

Vascular parameters in hamstring muscles Bars indicate SEM. N=3 to 4 per group. *P<0.05 relative to all other groups Ola Awad, et al. ATVB 2006;26:

Relative protein levels of angiogenic factors and their receptors in ischemic limbs - Changes in VEGF and the angiopoietin system 1 day after surgery and cell treatment Bars indicate SEM. P<0.01 solid bracket. P<0.05 dashed bracket. N=4 to 6 mice per group Ola Awad, et al. ATVB 2006;26:

Relative protein levels of angiogenic factors and their receptors in ischemic limbs - Changes in VEGF and the angiopoietin system 5 days after surgery and cell treatment Bars indicate SEM. P<0.01 solid bracket. P<0.05 dashed bracket. N=4 to 6 mice per group

Ola Awad, et al. ATVB 2006;26: Relative protein levels of angiogenic factors and their receptors in ischemic limbs - Changes in MCP-1 protein 1 day and 5 days after surgery and cell treatment Bars indicate SEM. P<0.01 solid bracket. P<0.05 dashed bracket. N=4 to 6 mice per group