Chapter 3 Proteins. Purpose Mostly for structure: skin, muscle, fingernails, hair.

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Presentation transcript:

Chapter 3 Proteins

Purpose Mostly for structure: skin, muscle, fingernails, hair

What is the “R” group? Variable part of the amino acid Amino Acid Chart (handout)Amino Acid Chart

Forming/Breaking Peptide Bonds

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Type of Proteins 8. Receptor Proteins Intercellular communication Bind to specific proteins (like hormones) Receptor Proteins

Note the H-bonds (between -O of carbonyl and -H of amino): coiling and pleating

Tertiary Folding: disulfide bridges Disulfide bridges formed between cysteine amino acids (Look at cysteine’s structure)

Disulfide Bridges Formed when cysteine’s sulfur join You Tube Videos Disulfide Bonds

Use the Amino Acid Reference Sheet Select the type of tertiary interaction as (1) disulfide(2) ionic (3) H bonds(4) hydrophobic A.Leucine and valine B.Two cysteines C.Aspartic acid and lysine D. Serine and threonine

ANSWERS Select the type of tertiary interaction as (1) disulfide(2) ionic (3) H bonds(4) hydrophobic A.4 Leucine and valine B.1 Two cysteines C.2 Aspartic acid and lysine D. 3 Serine and threonine

Two Basic Shapes Fibrous Strands Like hair, nails,skin, muscle fibers Globular Blobs Like hemoglobin, insulin, hormones, antibodies

Quaternary: combination of other shapes collagen

Identify the level of protein structure 1. Primary2. Secondary 3. Tertiary 4. Quaternary A. Beta pleated sheet B. Order of amino acids in a protein C. A protein with two or more peptide chains D. The shape of a globular protein E. Disulfide bonds between R groups

Identify the level of protein structure 1. Primary2. Secondary 3. Tertiary 4. Quaternary ANSWERS 2 Beta pleated sheet 1 Order of amino acids in a protein 4 A protein with two or more peptide chains 3 The shape of a globular protein 3 Disulfide bonds between R groups

Video Stuff Protein Denaturation Video (McGraw-Hill) Interactive Animations: Protein FoldingInteractive Animations Protein Structures Animation No Sound,but great molecular models

Denaturation Disruption of secondary, tertiary and quaternary protein structure by: heat/organics (Break apart H bonds and disrupt hydrophobic attractions) acids/ bases(Break H bonds between polar R groups and ionic bonds) heavy metal ions (React with S-S bonds to form solids) agitation (Stretches chains until bonds break)

NOTE: Denaturation does not break the primary structure Denaturation of an egg with a strong acid videoDenaturation of an egg with a strong acid video

Protein Extra Credit OPP Can bring in up to 5 labels (no repeats) for 1 point each with a protein term circled: – protein – peptide – amino

Proteins are Active DO PROTEIN ACTIVITY