Overview of the Chemical Threat Laboratory of Texas William Edgemond, Ph.D. Texas Department of State Health Services October 2013

Course Objectives  Introduction and Background  Who We Are  What We Can Do  What We Want You to Do

Chemical Threats

Laboratory Response Network International network of laboratories to respond quickly to high priority public health emergencies, such as biological, chemical, and radiological threats, through training, rapid testing, timely notification and secure messaging of laboratory results.

LRN-C Structure CDC Level 1 10 Labs Level 2 & Level 3 Activities National Surge Capacity Core Methods & Add’l Methods Additional Personal & Instruments Level 2 34 Labs Level 3 Activities Core Methods State/Local Response Capacity Level 3 9 Labs Competency in collecting and shipping clinical samples Comprehensive response plan

US Chemical Threat Labs           Level 1 Level 3 Level 2

Course Objectives  Introduction and Background  Who We Are  What We Can Do  What We Want You to Do

Personnel  Dr. Bill Edgemond Team Lead/Chemical Threat Coordinator  Jim Barnes Chemist  Jocelyn Hover-Jeansonne Chemist

How We Will Respond  Can easily handle a large number of samples utilizing Lab Check-in personnel and space

Types of Samples  Clinical Samples Blood Urine  Environmental/White Powders

Clincal Methods  CAP/CLIA Accredited Lab  11 Methods Developed by CDC 3 GC/MS Methods 4 LC-MS/MS Methods 3 ICP-MS Methods 1 LC-ICP-MS Methods

Instrumentation & Capabilities  Biosafety L2 Hood  Chemical Hoods  Automated Liquid Handler  Bar Code Reader  LIMS

GC-MS  Cyanide in Blood  Volatile Organic Compounds in Blood  Tetramine in Urine

ICP-MS  Cadmium, Lead, & Mercury in Blood  Trace Elements in Urine (Be, Co, Mo, Cd, Sb, Cs, Ba, W, Pt, Tl, Pb, U)  Arsenic & Selenium  LC-MS-ICP Lewisite (Chlorovinyl arsonous acid)

LC-MS/MS  Abrine/Ricinine  Organophosphorous Nerve Agent Metabolites  Tetranitromethane Metabolite (HNPAA)  Monofluoroacetate/ Monchloroacetate

Unknowns/White Powders  Typical submitted by FBI  Cleared by Bio Threat  Classify type of compound

Texas CT Lab  Know we’re here.  Know what we can do.  Share that with labs, hospitals and first responders across the state.

Unknowns/White Powders  FT-IR  FT-IR Microscope  XRF  Geiger Counter  Volatiles Detector  Wet Chemistry Tools

CT Lab Contact Info  —Direct Lab Phone.  —24-hour Emergency Phone.  – Chemical Threat Coordinator  -- DSHS Chemical Emergency Website  -- CDC Chemical Emergency Website

Texas CT Lab

Questions