MiRTLE Medical, LLC. 12-Lead ECG During MRI Jay Ward Executive Vice-President iCMR February 5, 2015 1.

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Presentation transcript:

MiRTLE Medical, LLC. 12-Lead ECG During MRI Jay Ward Executive Vice-President iCMR February 5, 2015 1

12-Lead ECG During MRI MiRTLE Medical, LLC. Intellectual Property Initial work October 2010 Founded December 2012, privately held Majority owned by E-TROLZ, Inc. Intellectual Property Brigham & Women’s Hospital, Boston, MA Acquiring patient physiological information during MRI scan E-TROLZ, Inc. Electrophysiological acquisition & signal processing device Product Development Validation complete through third-generation prototype device Building final design Beta device

Typical ECG Recording ECG signal obliterated by gradient induced interference during an SSFP sequence

Theoretical Induced Voltages Martin Bencsik, Richard Bowtell and Roger Bowley, Physics in Medicine & Biology 52 2007

Measured Induced Voltages Sequence Iso-center location Lead-I Heart (mV p-p / µs) Lead-II Heart Lead-II Nose SSFP 1340 / 62.5-156 1800 / 62.5-156 2850 / 125-281 GRE 1 slice 640 / 62.5-219 1860 / 62.5-156 3140-3400 / 219-250 GRE 20 slice 535 / 125 – 188 1580-2150 / 62.5-125 Not Recorded TSE 700-3470 / 62.5-156 EPI 1560 / 156-1400 2380 / 94-188 3440 / 62.5-219 Localizer 970 / 62.5-125 3245-3610 / 125-250 Table 1: 32 KSPS Pulse amplitude (mV p-p) / duration (µs) Data recorded on a Siemens Skyra 221L-3T

MiRTLE ECG Performance – GRE II III aVR aVL aVF V1 V2 V3 V4 V5 V6 Near perfect gradient induced interference removal

MiRTLE ECG Performance – SSFP II III aVR aVL aVF V1 V2 V3 V4 V5 V6 Sequence used for Interventional MRI due to imaging speed

Imaging During ECG Acquisition

Device Road Map Feature Proto3 Next Generation FDA Device Now Q4’2015 Now Q4’2015 2017 ECG 12-Lead, diagnostic grade P Patient safety Beat detection at 3T Scanner gating Diagnostic quality ECG during scan SSFP, GRE, TSE, EPI sequences cleansed 3 of 4 MHD real-time removal Dual imaging modalities with uninterrupted monitoring Stroke volume estimation Continuous comparison with baseline ECG morphology SPO2 Dual Invasive Blood Pressure

Jay Ward 978. 688. 8825 x13 jay. ward@e-trolz. com Dr Jay Ward 978.688.8825 x13 jay.ward@e-trolz.com Dr. Ehud Schmidt ESCHMIDT3@PARTNERS.ORG Dr. Zion Tse ziontse@uga.edu