Need for and prevalence of separate guidelines List of substances: Ba, Cu, CN -, F -, Ni, Phenol, V ( cadmium evaluated, default SCTL protective of acute.

Slides:

Advertisements

Similar presentations

1 Consumer Exposure Assessment at the U.S. Environmental Protection Agency: A ccomplishments and Opportunities for Global Collaboration Thomas Brennan.

Advertisements

Spanish Royal Decree for the statement of polluted soils Real Decreto 9/2005 (B.O.E nº15, 18 of January, 2005) JRC Meeting, 3-4 February, 2005 The criteria.

Application of ERICA outputs and AQUARISK to evaluate radioecological risk of effluents from a nuclear site J. Twining & J. Ferris Objectives of this study.

CATION EXCHANGE CAPACITY

Office of New Animal Drug Evaluation Laura L. Hungerford, DVM, MPH, PhD Senior Advisor, Science and Policy, ONADE Professor, University of Maryland School.

Risk Assessment Vs Exposure Assessment - the Future ? Tom Germann, CIH Naval Hospital, Jacksonville FL.

Do we have a problem with freshwater Kd values? B. Howard and E. Tipping CEH, UK Analysis for discussion only – do not quote.

Alternate approach to developing target levels Increasingly common ( NASA, NRC, USEPA ) Statistical vs deterministic inputs ( can be combined ) Addresses.

Revisiting the Formula CTL Workgroup Contaminated Media Forum 1.

Preventing Medication Errors in Pediatric and Neonatal Patients

1 Midland Community Meeting Michigan Department of Environmental Quality Steven Chester, Director Jim Sygo, Deputy Director.

Regulatory Toxicology James Swenberg, D.V.M., Ph.D.

CONFERENCE ON “ FOOD ADDITIVES : SAFETY IN USE AND CONSUMER CONCERNS“ JOMO KENYATTA UNIVERSITY OF AGRICULTURE AND TECHNOLOGY NAIROBI, 24 JUNE 2014.

Material Safety Data Sheets (MSDS)

Toxicological Assessment Heinz Hofer ARC Seibersdorf research GmbH Department of Toxicology.

Risk Assessment.

Risk Assessment: A Conceptual Introduction

29 th International conference SEGH, 8-12 July Toulouse, FRANCE 2013 Health risk estimate for groundwater and soil contamination in the.

TOXIC BOTTLES? CHAPTER 3 INFORMATION LITERACY

1 Uncertainty in Ecological Risk Assessments Larry Tannenbaum, U.S. Army Center for Health Promotion and Preventive Medicine (USACHPPM)

Food Advisory Committee Meeting December 16 and 17, 2014 Questions to the Committee Suzanne C. Fitzpatrick, PhD, DABT Senior Advisory for Toxicology Center.

(IAQ). What is Risk Assessment? Risk assessment: provides information on the health risk Characterizes the potential adverse health effects of human exposures.

Toxicology Concepts.

An Experimental Model of Human Absorptive Enterocytes (Caco-2) to Assess the Bioavailability of Various Metals Jonas Tallkvist Department of Biomedical.

Approaches for Evaluating the Relevance of Multiroute Exposures in Establishing Guideline Values for Drinking Water Contaminants Kannan Krishnan, Université.

“The Dose makes the Poison”

INTRODUCTION TO TOXICOLOGY SIDNEY GREEN, PH.D. DEPARTMENT OF PHARMACOLOGY COLLEGE OF MEDICINE HOWARD UNIVERISTY.

Forging Partnerships on Emerging Contaminants November 2, 2005 John Vandenberg Associate Director for Health National Center for Environmental Assessment.

Trichloroethylene (TCE) Update Waste Site Cleanup Advisory Committee Meeting January 24, 2013.

CLASSES OF CHEMICALS Toxic Chemicals Reactive Chemicals Flammables

The Vieques Problem By Monique Latalladi. Table of Contents Background / History Definition of Problem ATSDR findings Documentation Analysis Conclusion.

Water Quality Criteria: Implications for Testing Russell Erickson U.S. Environmental Protection Agency Mid-Continent Ecology Division, Duluth, MN, USA.

History of Pediatric Labeling

Public Health Assessment Process Jack Hanley, M.P.H. Environmental Health Scientist Agency for Toxic Substances and Disease Registry.

Risk Assessment.

Environmental Health and Toxicology

Chapter 15.3 Risk Assessment 2002 WHO report: “Focusing on risks to health is the key to preventing disease and injury.” risk assessment—process of evaluating.

Air Toxics Risk Assessment: Traditional versus New Approaches Mark Saperstein BP Product Stewardship Group.

By Michelle Hoang Period 2 APES April 30, 2012 The Toxic Substances Control Act of 1976.

Unit 3 – Environmental Chemistry.  A pollutant is any material or energy that can cause harm to a living thing.  Pollution is a change to the environment.

DoD Comments to NRC Committee on Improvements to EPA Risk Analysis Yvonne P. Walker, MS, MSE, CIH Director, Environmental Programs Navy Environmental Health.

TOXICOLOGY OCCUPATIONAL HAZARDS CHEMICAL PHYSICAL ERGONOMIC PSYCHOLOGIC BIOLOGIC.

CONSEQUENCE ASSESSMENT. Consequence Assessment Definition: The analysis, evaluation, and interpretation of available information associated with an actual.

RISK DUE TO AIR POLLUTANTS

Science of Toxicology The science of toxicology (tossicologia) is based on the principle that there is a relationship between a toxic reaction (the response)

1. Consumers, Health, Agriculture and Food Executive Agency Risk assessment with regard to food and feed safety Risk analysis Why risk assessment in the.

UNIT 9 Hazardous Wastes and Risk Assessment. Major Public Agencies Involved in Environmental Health Risk Assessment and Intervention Consumer Product.

Patricia Gillis Copper Sensitivity in Glochidia: Assessing the Effect of Water Composition on the Sensitive Larvae of Freshwater Mussels.

MEASUREMENT OF TOXICITY By, Dr. M. David Department of Zoology, Karnatak University Dharwad.

DOSE-RESPONSE ASSESSMENT

Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children: Cardiovascular.

C.P.Martinez and L.M. Porticos

Anniston PCB Site Review of Risk Assessments for OU-1/OU-2

Diane Jackson, PE, Hatice Zahran, MD, MPH, Greg Zarus, MS

Risk, Perception, Assessment, and Management Pertemuan 3

Milton Tenenbein, MD University of Manitoba

Dr. Daniele Wikoff – ToxStrategies Experimental Biology 2017

THE DOSE MAKES THE POISON

Environmental Risk Assessment

Environmental Toxicology

Treatment, Storage, and Disposal (TSD) Workers

A Short Update on Perfluorinated Alkyl Substances (PFAS)

ASSESSING THE ENVIRONMENTAL CONSEQUENCE OF POTENTIAL MAJOR ACCIDENTS

Environmental sampling and monitoring

Material Safety Data Sheets (MSDS)

© The Author(s) Published by Science and Education Publishing.

INTENTIONAL HUMAN DOSING STUDIES (IHDS)

Pesticides & Children: Ten Years After FQPA

VICH GL 54, Studies to evaluate the safety of residues of veterinary drugs in human food: General approach to establish an Acute Reference Dose (ARfD)

Presentation transcript:

Need for and prevalence of separate guidelines List of substances: Ba, Cu, CN -, F -, Ni, Phenol, V ( cadmium evaluated, default SCTL protective of acute tox too ) Ingestion rate: 10 grams one event ( 50x default ) Review of tox values to be used Bioavailability: Assumed 100% Acute Toxicity SCTL Issues Draft Copy Subject To Change

Need / Prevalence Pica behavior recognized, but acute exposure harm? FL sites can be driven by acute tox values ( e.g., Ba ) Other states/federal/international guidance – CA ( HHSLs don’t include acute exposure ) – MA ( CN - only ) – MN ( Ba, Cu, CN -, F -, Phenol ) – NY ( As, Ba, Cd, Cu, CN -, Ni, Naph, Penta, Phenol ); cites FL as basis – USEPA ( RSLs do not address acute exposure ) – Canada ( CN - only ) Regulation of other media ( GW, SW ) does not single out extreme outlier population Draft Copy Subject To Change

List of Chemicals CN - and phenol have reasonable basis in tox Tox of Ba, Cu, F -, Ni, V lacks good foundation Endpoints for some are ambiguous, transient, reversible; should have real hazard potential Same substances present in dietary, commercial products at higher levels Draft Copy Subject To Change

Ingestion Rate 10 gram, single event existing assumption – Historical support as infrequent acute exposure – More indicative of extreme pica or geophagy Frequency of events ( e.g., 33% may ingest 10g 1-2 times per year ), often cited but weakly supported Calabrese et al. (1997) cites 200 mg/day protects 95% of children 1 to 5 gram range for pica recommendation (2011 EFH, 2008 Child EFH, CalEPA 2012, literature) Draft Copy Subject To Change

Toxicological Guidance RfD acute values developed from human studies RfD acute for some substances set very close to acceptable dietary recommendations Large soil bolus alone may cause adverse effects Existing dose/response from nonsoil exposures Majority of effects gastrointestinal, transient Draft Copy Subject To Change

Bioavailability Chemical-specific, but defaults to 100% Limited or no literature for most chemicals Other default recommendations ( e.g., 50% MADEP ) Single acute exposures beg question: Are there no reports of effect because toxins unavailable Draft Copy Subject To Change