Efficacy of prostaglandin E1 in the treatment of lower extremity ischemic ulcers secondary to peripheral vascular occlusive disease James J. Schuler,

Slides:

Advertisements

Similar presentations

Preoperative Evaluations: The Very Last Chance To Identify a Problem With a Pacemaker or Implanted Cardioverter-Defibrillator Marc A. Rozner, PhD, MD Journal.

Advertisements

Professionalism and the work-life balance Thomas S. Huber, MD, PhD Journal of Vascular Surgery Volume 60, Issue 4, Pages (October 2014) DOI:

Clinical evaluation of recombinant human platelet – derived growth factor for the treatment of lower extremity diabetic ulcers David L. Steed, MD, the.

Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy Monica B. Arvidsson, MD, Olle.

Evaluation and treatment of allergic fungal sinusitis. II

Axillary-to-carotid artery bypass grafting for symptomatic severe common carotid artery occlusive disease Joseph P. Archie, PhD, MD Journal of Vascular.

Multidisciplinary care improves amputation-free survival in patients with chronic critical limb ischemia Jayer Chung, MD, J. Gregory Modrall, MD, Chul.

Wen Jing Chung, MD, MS, Gregory H. Pharo, DO

Evaluation and treatment of allergic fungal sinusitis. II

A Phase II Pilot Study to Evaluate Use of Intravenous Lidocaine for Opioid-Refractory Pain in Cancer Patients Shekhar Sharma, MS, M.R. Rajagopal, MD,

One-year prospective quality-of-life outcomes in patients treated with angioplasty for symptomatic peripheral arterial disease Corey A. Kalbaugh, MS,

The association of chronic kidney disease and dialysis treatment with foot ulceration and major amputation Jeroen Otte, MD, MSc, Jaap J. van Netten,

Defining successful mobility after lower extremity amputation for complications of peripheral vascular disease and diabetes Daniel C. Norvell, PhD, Aaron.

In search of optimal compression therapy for venous leg ulcers: A meta-analysis of studies comparing divers bandages with specifically designed stockings

Comparison of low-strength compression stockings with bandages for the treatment of recalcitrant venous ulcers Eugenio Brizzio, MD, Felix Amsler, MS,

Infliximab treatment for severe psoriasis in a patient with active hepatitis B virus infection Alberto Conde-Taboada, MD, Javier Pedraz Muñoz, MD, Lucía.

Badrul A. Chowdhury, MD, PhD

NMDA-Receptor Antagonists in Neuropathic Pain

Comparison of low-strength compression stockings with bandages for the treatment of recalcitrant venous ulcers Eugenio Brizzio, MD, Felix Amsler, MS,

Double-Blind, Placebo-Controlled Trial of Lamotrigine in Combination with Other Medications for Neuropathic Pain Marianne Silver, MS, David Blum, MD,

Comparison of the efficacy of budesonide and fluticasone propionate aqueous nasal spray for once daily treatment of perennial allergic rhinitis James.

Daniel J. Amaranto, BA, Farah Abbas, MS, Seth Krantz, MD, William H

Effects of exercise rehabilitation on cardiovascular risk factors in older patients with peripheral arterial occlusive disease Anna Maria Izquierdo-Porrera,

Open bypass and endovascular procedures among diabetic foot ulcer cases in the United States from 2001 to 2010 Grant H. Skrepnek, PhD, David G. Armstrong,

The association of chronic kidney disease and dialysis treatment with foot ulceration and major amputation Jeroen Otte, MD, MSc, Jaap J. van Netten,

Effectiveness of an extracellular matrix graft (OASIS Wound Matrix) in the treatment of chronic leg ulcers: A randomized clinical trial Eliot N. Mostow,

Peripheral arterial disease affects kinematics during walking

Louis L. Nguyen, MD, MBA, MPH Journal of Vascular Surgery

Transdermal Fentanyl for Chronic Pain in AIDS

Long-term safety of cilostazol in patients with peripheral artery disease: The CASTLE study (Cilostazol: A Study in Long-term Effects) William R. Hiatt,

Clinical relevance of peripheral vascular occlusive disease in patients with rheumatoid arthritis and systemic lupus erythematosus 1 Peter K Henke, MD,

The first operation on the profunda femoris artery

Redefining Appropriate Treatment Expectations

Collateral artery from arteriovenous malformation of the rectum in a patient with peripheral artery disease Hirotomo Uchiyama, MD, Reiji Hattori, MD,

Infected aneurysm of the thoracic aorta

The Role of Patients' Expectations in the Development of Anticipatory Nausea Related to Chemotherapy for Cancer Jane T. Hickok, MD, MPH, Joseph A. Roscoe,

“Better” (sometimes) in vascular disease management

The adverse effects of race, insurance status, and low income on the rate of amputation in patients presenting with lower extremity ischemia Mohammad.

Strategies in Pain Management

Subclavian steal despite ipsilateral vertebral occlusion

Randomized trial of balneotherapy associated with patient education in patients with advanced chronic venous insufficiency Patrick H. Carpentier, MD,

Safety and efficacy of patient specific intramuscular injection of HGF plasmid gene therapy on limb perfusion and wound healing in patients with ischemic.

Peter Neglén, MD, PhD, Kathryn C. Hollis, BA, Seshadri Raju, MD

Peter Neglén, MD, PhD, Seshadri Raju, MD Journal of Vascular Surgery

Todd R. Vogel, MD, MPH, Robin L. Kruse, PhD

Rapid foot and calf compression increases walking distance in patients with intermittent claudication: Results of a randomized study Ganesh Ramaswami,

Patient recovery after intermittent disc escape and spontaneous recession of a mechanical heart valve Francis Robicsek, MD, PhD, Joseph W. Cook, MD

Increase in size of the pulmonary autograft after the ross operation in children: Growth or dilation? Laszlo Solymar, MD, PhD, Göran Südow, MD, Daniel.

Reviewer Acknowledgment

Perceived Success in Addressing End-of-Life Care Needs of Low-Income Elders and Their Families: What Has Family Conflict Got to Do With It? Betty J.

Knowledge and Attitudes of Italian Medical Staff Towards the Approach and Treatment of Patients in Pain Marco Visentin, MD, Leonardo Trentin, MD, Roberto.

Lower extremity ischemia in adults younger than forty years of age: A community-wide survey of premature atherosclerotic arterial disease Pavel J. Levy,

Martin E. Harrington, MD, Myron E. Schwartz, MD, Timothy A

Correlation of operative findings with angiographic and noninvasive hemodynamic factors associated with failure of polytetrafluoroethylene grafts Thomas.

Does a standardization tool to direct invasive therapy for symptomatic lower extremity peripheral arterial disease improve outcomes? Mark P. Androes,

James R. Burnett, MB, BS, FRACS, Robert J. Lusby, MD, FRCS, FRACS

Aortofemoral or femoropopliteal revascularization

Glauco Milio, MD, Chiara Minà, MD, Valentina Cospite, MD, Piero L

Joseph G. Magnant, MD, Jack L. Cronenwett, MD, Daniel B

Gregory C. Schmieder, MD, Megan Carroll, BA, BS, Jean M. Panneton, MD

James E. Edwards, MD, Lloyd M. Taylor, MD, John M. Porter, MD

Long-Term Outcomes of an Endovascular-First Approach for Diabetic Patients With Predominantly Tibial Disease Caitlin W. Hicks, MD, MS, Joseph K. Canner,

Peripheral arterial occlusion in infants—A report of two cases treated conservatively Andrea Pettenazzo, MD, Piergiorgio Gamba, MD, Giovanna Salmistraro,

Appropriate Use Criteria for coronary revascularization in patients with stable ischemic heart disease: What the surgeon needs to know Harold L. Lazar,

James A. DeWeese, MD Journal of Vascular Surgery

Scott A. Berceli, MD, PhD, Allen K. Chan, MD, Frank B

Therapeutic angiogenesis in patients with severe limb ischemia by transplantation of a combination stem cell product Gabriel P. Lasala, MD, FACC, Jose.

Axillary-to-carotid artery bypass grafting for symptomatic severe common carotid artery occlusive disease Joseph P. Archie, PhD, MD Journal of Vascular.

Nausea and Vomiting Remain a Significant Clinical Problem

Prospective randomized study evaluating an absorbable cyanoacrylate for use in vascular reconstructions Alan B. Lumsden, MD, Eugene R. Heyman, PhD Journal.

Presentation transcript:

Efficacy of prostaglandin E1 in the treatment of lower extremity ischemic ulcers secondary to peripheral vascular occlusive disease James J. Schuler, M.D., D.Preston Flanigan, M.D., James W. Holcroft, M.D., Joseph J. Ursprung, Ph.D., J.Scott Mohrland, Ph.D., Judy Pyke, M.S. Journal of Vascular Surgery Volume 1, Issue 1, Pages 160-170 (January 1984) DOI: 10.1016/0741-5214(84)90195-2 Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 1 Final result of PGE1 vs. placebo treatment showing percent of ulcers that healed completely, were reduced by 20% or more in surface area, remained unchanged or increased by 20% or more, developed during the course of treatment, and had inadequate follow-up. The differences between treated group and placebo were not significant. Journal of Vascular Surgery 1984 1, 160-170DOI: (10.1016/0741-5214(84)90195-2) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 2 Percent of patients in two groups with at least one ulcer completely healed during course of study. Journal of Vascular Surgery 1984 1, 160-170DOI: (10.1016/0741-5214(84)90195-2) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 3 Percent of patient in two groups who had a 20% or greater reduction in total ulcer surface area as compared with those that remained unchanged or increased by 20% or more following one infusion of PGE1 or placebo. Differences between two groups were not significant. Journal of Vascular Surgery 1984 1, 160-170DOI: (10.1016/0741-5214(84)90195-2) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 4 Percent of patients in two groups who had a 20% greater reduction in total ulcer surface area as compared with those that remained unchanged or increased or increased by 20% or more at final follow-up visit 2 months after last infusion. Differences between two groups were not significant. Journal of Vascular Surgery 1984 1, 160-170DOI: (10.1016/0741-5214(84)90195-2) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 5 Average of patients' subjective evaluation of degree of rest pain graded on a scale of 0 to 7 prior to beginning of treatment and at time of final follow-up 2 months after last infusion. These differences were not significant. Journal of Vascular Surgery 1984 1, 160-170DOI: (10.1016/0741-5214(84)90195-2) Copyright © 1984 Mosby, Inc. Terms and Conditions

Fig. 6 Average of analgesic medication use required for relief of rest pain graded on a scale of 0 to 5 prior to beginning of treatment and at time of final follow-up 2 months after last infusion. These differences were not significant. Journal of Vascular Surgery 1984 1, 160-170DOI: (10.1016/0741-5214(84)90195-2) Copyright © 1984 Mosby, Inc. Terms and Conditions