Notching Up MYC Gives a LIC

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Presentation transcript:

Notching Up MYC Gives a LIC David Levens, Peter D. Aplan Cell Stem Cell Volume 13, Issue 1, Pages 8-9 (July 2013) DOI: 10.1016/j.stem.2013.06.008 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 FBXW7 via MYC Amplifies Notch1-Induced Leukemogenesis by Increasing MYC Protein Levels Left: activated Notch1 after a latent period yields T-ALL. Leukemia-initiating cells (LICs) require high levels of MYC (saturated red), but throw off (green arrow) bulk leukemia cells expressing lower levels of MYC (pale red). Wild-type FBXW7 depresses MYC levels. We speculate that stochastic elevation of MYC may help promote a bulk leukemia cell to a LIC (pale red arrow). Right: mutated FBXW7 increases MYC and increases the frequency and numbers of LICs. Cell Stem Cell 2013 13, 8-9DOI: (10.1016/j.stem.2013.06.008) Copyright © 2013 Elsevier Inc. Terms and Conditions