ATP analogs have little effect on the conformation of the 2CARD domain

Slides:

Advertisements

Similar presentations

Fig. 5 Correlation of RNA expression and protein abundance.

Advertisements

Fig. 4 The extracellular domain of sortilin is sufficient for BDNF/TrkB signaling. The extracellular domain of sortilin is sufficient for BDNF/TrkB signaling.

Fig. 3 The electrical contact of direct-printed and reconfigured liquid metals. The electrical contact of direct-printed and reconfigured liquid metals.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)

Fig. 3 Oil, gas, and FP water variations with time.

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 1 Map of water stress and shale plays.

Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 3 Electron PSD in various regions.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 6 Comparison of properties of water models.

Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.

Fig. 2 Reference-fixing experiment, results.

Fig. 2 Ferroelectric domains resolved in WTe2 single crystals.

Fig. 2 Average number of fake news shares (and 95% CIs) using the list of domains derived from (7). Average number of fake news shares (and 95% CIs) using.

m6A identification method based on m6A sensitive RNA endoribonuclease

Fig. 3 Scan rate effects on the layer edge current.

Fig. 3 Rotation experiment, setup.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 3 Gate voltage dependence of the areal iDMI and PMA.

Fig. 1 Bioinspired design of AAD for promoting wound contraction.

Fig. 3 Affective responses by exchange condition (PR and RE), level of redistribution (0 = random, one-card, and two-card exchange), and outcome as winner.

Fig. 1 Proportions of normative beliefs by exchange condition, level of redistribution (0 = random, one-card, and two-card exchange), and outcome as winner.

Fig. 1 Distribution of total and fake news shares.

Fig. 2 2D QWs of different propagation lengths.

Fig. 1 Impacts of intensified acidification on stream pH and calcium concentration. Impacts of intensified acidification on stream pH and calcium concentration.

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Fig. 1 Histograms of the number of first messages received by men and women in each of our four cities. Histograms of the number of first messages received.

Fig. 5 Schematic phase diagrams of Ising spin systems and Mott transition systems. Schematic phase diagrams of Ising spin systems and Mott transition systems.

Fig. 1 X-ray scattering and EBSD analyses of the bulk Fe25Co25Ni25Al10Ti15 HEA. X-ray scattering and EBSD analyses of the bulk Fe25Co25Ni25Al10Ti15 HEA.

Fig. 4 OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with different pH. OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with.

Fig. 1 Average contribution (million metric tons) of seafood-producing sectors, 2009–2014. Average contribution (million metric tons) of seafood-producing.

Fig. 4 The mechanical performances of thermally stable click-ionogels.

Fig. 4 Evolution of fraction of sickled RBCs under hypoxia.

Fig. 3 Abundance for all OR-expressing OSN subtypes across mammalian evolution. Abundance for all OR-expressing OSN subtypes across mammalian evolution.

Fig. 4 Visualization of complex loop motions by 1-μs MD trajectories.

Fig. 3 Production of protein and Fe(II) at the end of growth correlated with increasing concentrations of ferrihydrite in the media that contained 0.2.

Fig. 2 Desirability, quantified using the measures defined here, as a function of demographic variables of the user population. Desirability, quantified.

Fig. 2 NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ clean air policy. NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ.

Fig. 3 Avoidable fraction of heat-related deaths if the current trajectory warming of 3°C is brought down to the 1.5° or 2°C Paris Agreement thresholds.

Fig. 2 Top 10 countries, ecoregions, conservation hotspots, and KBAs with the largest area of restoration hotspots. Top 10 countries, ecoregions, conservation.

Analysis of A-to-I RNA edits found in transcriptome-wide RNA-seq

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Fig. 6 Experimental setup and properties of the IP screen.

Fig. 3 FTIR spectra of plastic standards and sediment samples.

Fig. 1 Location of the Jirzankal Cemetery.

Fig. 4 Map of δ18OVSMOW in groundwaters of the British Isles (left) and Strontium (87Sr/86Sr) biosphere map of Great Britain (right). Map of δ18OVSMOW.

Fig. 4 CO2 emission changes triggered by the JJJ clean air policy.

Fig. 6 Stabilization of hippocampal signaling over sleep.

Fig. 3 Comparisons of NDVI trends over the globally vegetated areas from 1982 to Comparisons of NDVI trends over the globally vegetated areas from.

Fig. 1 Effects of experimental warming on nematode communities across the gradient of plant species richness. Effects of experimental warming on nematode.

Fig. 2 Particles detected in snow samples collected at different locations from Europe to the Arctic. Particles detected in snow samples collected at different.

Fig. 1 Schematic depiction of a paradigm for rapid and guided discovery of materials through iterative combination of ML with HiTp experimentation. Schematic.

Fig. 4 Mapping of abundance of the most dominant bacterial and archaeal phyla across France. Mapping of abundance of the most dominant bacterial and archaeal.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 4 Single-particle contact angle measurements.

Fig. 3 Supraballs and films assembled from binary 219/217nm SPs/SMPs.

Fig. 2 Supraballs and films from binary SPs.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Fig. 4 Behavior of resistance peak near density nm = 5.

Fig. 2 Comparison between the different reflective metasurface proposals when θi = 0° and θr = 70°. Comparison between the different reflective metasurface.

Fig. 1 Design principle and SEM characterization of super-origami DNA nanostructures with n-tuples. Design principle and SEM characterization of super-origami.

Fig. 2 Polymer-mediated optical activation of TRPV1 stimulates proliferation in ECFCs. Polymer-mediated optical activation of TRPV1 stimulates proliferation.

Fig. 2 Daily TNC pickups and drop-offs for an average Wednesday in fall 2016 (1). Daily TNC pickups and drop-offs for an average Wednesday in fall 2016.

Fig. 3 Supercurrents in various conductance plateau regions.

Fig. 1 Design of a FRET reporter for RIG-I activation.

Fig. 3 Calculated electronic structure of ZrCoBi.

Fig. 4 Electrochemical mechanism studies.

Fig. 2 Time series of secularization versus GDP per capita, from four illustrative countries, over the 20th century. Time series of secularization versus.

Presentation transcript:

Fig. 4 ATP analogs have little effect on the conformation of the 2CARD domain. ATP analogs have little effect on the conformation of the 2CARD domain. RIG-I was mixed with RNA, followed by the indicated ATP analog. A one-way analysis of variance (ANOVA) identified an effect of ATP analog on 2CARD ejection (F5,12 = 9.362, P = 0.0008) and a Dunnett’s post hoc test identified adenosine diphosphate (ADP)–AlFx as the only sample significantly different from the +SLR14 sample that lacked ATP analog (*P = 0.0143). Error bars correspond to the SEM across replicate samples. T. H. Dickey et al. Sci Adv 2019;5:eaax3641 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).