Model of major transport processes and regulatory mechanisms in type B intercalated cells. Model of major transport processes and regulatory mechanisms.

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Presentation transcript:

Model of major transport processes and regulatory mechanisms in type B intercalated cells. Model of major transport processes and regulatory mechanisms in type B intercalated cells. This cartoon is modified from the model proposed by Chambrey and colleagues (35). These cells participate in electroneutral NaCl absorption, which is energized by H+-ATPase. Two cycles of transport via pendrin, when coordinated with one cycle of NDCBE results in net uptake of one Na+ and one Cl− and the extrusion of two bicarbonate (HCO3−) ions. The Cl− ions recycle across the apical membrane. A basolateral channel (not shown) mediates Cl− exit. The basolateral anion exchanger 4 (AE4 or Slc4a9), together with the H+-ATPase also facilitates Na+ and bicarbonate exit. Ankita Roy et al. CJASN 2015;10:305-324 ©2015 by American Society of Nephrology