In a cohort of chronically hyponatremic patients with serum sodium concentrations ≤105 mEq/L, post-therapeutic (post-Rx) neurological complications occurred.

Slides:

Advertisements

Similar presentations

HYPONATREMIA AND THE EMERGING ROLE OF TOLVAPTAN IN CARDIOLOGY

Advertisements

WHAT ARE THE PRINCIPLES IN THE TREATMENT OF HYPOKALEMIA? Question # 6.

Severe Hypernatremia Following Treatment of the Syndrome of Inappropriate Antidiuretic Hormone Secretion Khaldoun Soudan, MD, Wajeh Qunibi, MD The American.

Management of Hyponatremia in the ICU

Relationship between serum sodium after racing and the weight change (in %) during exercise in 2135 athletes who competed in endurance events. •, asymptomatic.

Among Medicare beneficiaries >65 years old with a index hospitalization at the time of dialysis initiation, use of post-acute SNF care was common. Among.

Suggested approach to patients with dabigatran-associated bleeding

Positive interactions between the basic and translational research, clinical research, patient care, and training components of an academic dialysis access.

Adjusted all-cause mortality risk by dialysate sodium (DNa) and predialysis serum sodium (SNa). Adjusted all-cause mortality risk by dialysate sodium (DNa)

Figure 1.17 of the 2016 US Renal Data System Annual Data Report, Volume 2, chapter 1 showing the trends in the number of patients with incident ESRD (in.

Shalin R. Sanghvi, MD, Paul S. Kellerman, MD, Lisa Nanovic, DO

Mechanism by which negative sodium and water balance may improve myocardial and renal function in CHF. [Reprinted from J Am Coll Cardiol, vol. 47, Schrier.

Probability of cumulative incidence of ESRD, disease-related death, or death from other cause for the entire cohort. Probability of cumulative incidence.

Protocol for management of adult patients with DKA or HHS

Pathophysiology and Management of Preeclampsia-Associated Severe Hyponatremia Gagangeet Sandhu, MD, Senthil Ramaiyah, MD, Germaine Chan, MD, Ira Meisels,

Pathogenesis of Hyponatremic Encephalopathy Current Concepts

Treatment of severe hyponatremia

Is it cerebral or renal salt wasting?

Overcorrection of hyponatremia is a medical emergency

Volume 87, Issue 2, Pages (February 2015)

Correction to "Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate.

Parathyroid hormone (PTH) levels by Dialysis Outcomes and Practice Patterns Study (DOPPS) phase and selected patient characteristics. Parathyroid hormone.

Patient disposition. Patient disposition. AE, adverse event. *One patient died during the follow-up period. ^Four of the 12 discontinuations of treatment.

Incidence of in-hospital mortality rates are lower in rapid correction rate group versus slow correction rate group but not significantly different by.

Thirty-day survival curves for the rapid versus slow correction rate groups are not significantly different. Thirty-day survival curves for the rapid versus.

Volume 79, Issue 2, Pages (January 2011)

Volume 80, Issue 3, Pages (August 2011)

Secondary (assisted survival) patency for grafts by drug therapy (aspirin [dashed line] versus no aspirin [solid line]). Secondary (assisted survival)

Patient 2, who presented with delirium as a result of a plasma sodium concentration (PNa) of 115 mmol/L and alcohol withdrawal, was given multiple doses.

(A) Mean (SD) serum continuous erythropoietin receptor activator (C. E

Distribution of podocyte gene mutations in patients with genetic congenital nephrotic syndrome (CNS) and steroid–resistant nephrotic syndrome (SRNS). Distribution.

Ionized-to-total magnesium (Mg) and calcium (Ca) ratios are lower in patients on hemodialysis than those in patients not on dialysis. Ionized-to-total.

Ratio of actual to expected rise in sodium as calculated using the Adrogué-Madias formula. Ratio of actual to expected rise in sodium as calculated using.

Mean plasma concentrations of ampicillin/sulbactam in plasma of critically ill patients with AKI undergoing extended dialysis (duration depicted by box.

Volume 71, Issue 7, Pages (April 2007)

Where vaptans do and do not fit in the treatment of hyponatremia

PTH response to the predialysis serum calcium concentration in hemodialysis patients with severe (A), moderate (B), and mild (C) hyperparathyroidism. PTH.

A loading dose decreases the time to achieve the target concentration.

Clinical characteristics and laboratory parameters in relation to dose of oral sodium bicarbonate. Clinical characteristics and laboratory parameters in.

Volume 82, Issue 11, Pages (December 2012)

Mortality predictability of the difference of the percentiles of the changes in dietary protein intake, represented by nPNA (nPCR), and serum P concentration.

Rates of plasma sodium concentration increase before and after DDAVP administration. Rates of plasma sodium concentration increase before and after DDAVP.

Effects of DDAVP administration on PNa kinetics and urine composition and output. Effects of DDAVP administration on PNa kinetics and urine composition.

Serum bicarbonate increased by ≥3, ≥4, and ≥5 mEq/L in 52%, 39%, and 22% of patients, respectively, in the combined TRC101 dose group compared with 6%,

These data are derived from 21,374 patients with any form of glomerular disease identified in renal biopsy specimens evaluated by the University of North.

Graph showing percentage of total patients with PTD or IGT that would be detected in each category of FBG if an oral glucose tolerance test were performed.

Combination angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) reduced risk for renal end point versus ACEI or ARB. Effect.

Change in bone in patients who were treated with calcium or sevelamer.

Kaplan-Meier analysis for the cumulative percentage of patients who remained hospitalized according to presence or absence of ARF with or without other.

We identified 200 Android and 178 iOS apps using 4 search terms and narrowed this to 12 Android apps, 11 iOS apps, and 5 dual-platform apps after applying.

(Top) A urine sodium concentration (UNa) of approximately 30 mEq/L is observed frequently in patients with hyponatremia secondary to syndrome of inappropriate.

Mild chronic hyponatremia is associated with gait disturbances.

Among three residual kidney function (RKF) indices, only residual urine volume (UV) indicated an independent prognostic value in patients with UV≥0.1 or.

Distribution of percent consistent facility aspirin use.

New dialysis starts in the United States by year in patients with and without diagnosis of diabetes. New dialysis starts in the United States by year in.

Pathophysiology of acute decompensated heart failure

Three scenarios illustrate the possible relationships between hyponatremia and mortality. Three scenarios illustrate the possible relationships between.

Distribution of SDS for serum creatinine, serum BUN, SBP, and DBP per quintiles of KS. Quintiles are expressed in SDS (see Figure 1B): 1st quintile,

As the patient nears the end of life (dashed arrow), there is an increasing focus on symptom control and patient goals of care and a shift in the approach.

Bland-Altman plot of arterial and central venous blood Pco2 showing the regression line (solid line) and the 95% limits of agreement of −12.3 to 4.8 mmHg.

Limits for safe correction are difficult to define when the serum sodium concentration is extremely low. Limits for safe correction are difficult to define.

Plasma concentration-time profile after oral administration of a single dose. Plasma concentration-time profile after oral administration of a single dose.

Dosage-response gradient for colorectal cancer according to serum 25-hydroxyvitamin D [25(OH)D] concentration of five studies combined. Dosage-response.

Change in coronary artery calcification in patients who were treated with calcium or sevelamer. Change in coronary artery calcification in patients who.

Significant correlation between the initial urine osmolality (Uosm T0) and the variation in plasma sodium (DPNa) after 2 L of isotonic saline in 17 patients.

Prevalence of primary aldosteronism in patients according to Sixth Joint National Committee (JNC VI) stages of severity of hypertension (stage 1, 140 to.

Pancreas transplantation is performed at transplant centers within 56 of the 58 federally designated donor service areas (DSAs). Pancreas transplantation.

Effect of urine electrolyte concentration on serum sodium level in hypotonic hyponatremia. Effect of urine electrolyte concentration on serum sodium level.

Role of decreased baroreceptor sensitivity, and activation of RAAS and SNS in expansion of water and sodium retention as well as worsening HF. [Reprinted.

Effect of aspirin (ASA) on serum cytokine concentration in hemodialysis (HD) patients. Effect of aspirin (ASA) on serum cytokine concentration in hemodialysis.

Presentation transcript:

In a cohort of chronically hyponatremic patients with serum sodium concentrations ≤105 mEq/L, post-therapeutic (post-Rx) neurological complications occurred after correction by >12 mEq/L in 24 hours and >18 mEq/L in 48 hours. In a cohort of chronically hyponatremic patients with serum sodium concentrations ≤105 mEq/L, post-therapeutic (post-Rx) neurological complications occurred after correction by >12 mEq/L in 24 hours and >18 mEq/L in 48 hours. Patients with chronic hyponatremia refers to patients without psychotic polydipsia who became hyponatremic at home. Solid circles represent patients with post-therapeutic neurologic complications, and open triangles represent patients who recovered uneventfully. The dashed lines represent therapeutic limits identified by the study (12 mEq/L in 24 hours and 18 mEq/L in 48 hours). Modified from ref. 18, with permission. Richard H. Sterns CJASN 2018;13:641-649 ©2018 by American Society of Nephrology