Schematic representation of DCH and variants.

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Schematic representation of DCH and variants. Schematic representation of DCH and variants. (A) cDNA domains encoding scFv HD70-IL-2 and scFv HD70-GM-CSF polypeptide chains. Structure of (B) the DCH fusion protein; (C) DCH-mu variant with amino acid mutations in the hypervariable regions of the VL and VH domains; and (D) SCH variant without an IL-2 fusion at the C kappa C-terminus. Abbreviations: HD70 VL and VH, light and heavy chain variable region domains derived from the human anti-Ep-CAM Ab HD70; GS linker, glycine-serine linker peptide (G4S); IgG3 hinge, upper hinge region of human IgG3; C kappa, constant region domain of human Ig kappa light chain; CH1, first constant region domain of human IgG1 heavy chain; His6, hexahistidine tag. Juergen M. Schanzer et al. Cancer Immun 2006;6:4 Copyright © 2006 by Patrick A. Baeuerle